TWiV 908: COVID-19 clinical update #118 with Dr. Daniel Griffin
In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in hospitalized patients, and factors associated with hospital readmission.  Subscribe (free): Apple Podcasts, Google Podcasts,...
Source: This Week in Virology - MP3 Edition - June 11, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 906: Long COVID, giant viruses, and smallish pox
TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox update (ProMedMail) Multi-country monkeypox outbreak (WHO) Monkeypox new global threat (Science) Monkeypox outbreak 9 US states (MMWR) Mimivirus in human respiratory samples (Sci Rep) Long COVID after post-vaccination infection (Nat Med) Letters read on TWiV 906 Timestamps b...
Source: This Week in Virology - MP3 Edition - June 5, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 905: COVID-19 clinical update #117 with Dr. Daniel Griffin
In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen test positivity duration, viral dynamics of variants and isolation, association of inflammation in CS fluid, and transmission dynami...
Source: This Week in Virology - MP3 Edition - June 4, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 904: 50 years of reverse transcriptase
Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Various about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research. Hosts: Vincent Racaniello Guests: David Baltimore, John Coffin, and Harold Varmus Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Fifty Years of Reverse Transcriptase (Cold Spring Harbor Laboratory) 50th Anniversary of RT discovery (Mol Biol Cell) RT in virions of Rous sarcoma virus – Temin (Nature) RNA-dependent DNA polymerase in tumor v...
Source: This Week in Virology - MP3 Edition - May 29, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 903: COVID-19 clinical update #116 with Dr. Daniel Griffin
In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and bebtelovimab fact sheets for providers, guidelines on usage of anticoagulation drugs, long covid symptoms after vaccina...
Source: This Week in Virology - MP3 Edition - May 28, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV Special: Monkeypox clinical update with Dr. Daniel Griffin
In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox multi-country outbreak risk assessment (pdf, ECDC) Monkeypox update (ProMedMail) Monkeypox virus genome sequences (Nextstrain) Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - May 26, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 902: Autoantibodies drive severe COVID-19
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) Possible monkeypox in NYC (NY Times) Occupational monkeypox, Wisconsin (Emerg Inf Dis) SARS-CoV-2 in feces (Nature) IFN autoantibodies and severe COVID-19 (PNAS) Letters read on TWiV 902 Timestamps by Jolene. T...
Source: This Week in Virology - MP3 Edition - May 22, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without vaccination (Nature) EUA for boosters in 5-11 year olds (FDA) Stages of COVID-19 (AIDS Rev) B.1.1.529 attack rate in Australia (JID) Sce...
Source: This Week in Virology - MP3 Edition - May 21, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 900: Burning down the mouse
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture Infected macrophages drives severe COVID-19 (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Milky Way’s Black Hole Comes to Light Kathy – River dolphins playing with anaconda Rich – Smallpox vaccination techniq...
Source: This Week in Virology - MP3 Edition - May 15, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effects of early treatment with Ivermectin (NEJM) Procalcitonin not a reliable biomarker (IDSA) Evaluation of vaccine in children 6 t...
Source: This Week in Virology - MP3 Edition - May 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 898: Immunity is skin deep
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases skin bacteria (PLoS Path) The invinceable TWiV (TWiV 145) By the pricking of my thumbs… (TWiV 284) Letters read on TWiV 898 Timestamps b...
Source: This Week in Virology - MP3 Edition - May 8, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 897: COVID-19 clinical update #113 with Dr. Daniel Griffin
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Timing of Tocilizumab Use in Hospitalized Patients (NIH) Interleukin-6 inhibitors redu...
Source: This Week in Virology - MP3 Edition - May 7, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 896: Memory B cells, the way we were
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 896 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Toots Thilelemans Amy – Largest comet ever identified Vincent – Sc...
Source: This Week in Virology - MP3 Edition - May 1, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Authorization for Vaccine in Young Children Filed (Moderna) Public Health Impact of Vaccines in US (BMJ) FDA authorizes first approved t...
Source: This Week in Virology - MP3 Edition - April 30, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 894: Dinner with the TMPRSS family
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Severe hepatitis in children (WHO) TMPRSS2 inhibitor (Nature) Omicron less dependent on TMPRSS2 (TWiV 879) Letters read on TWiV 894 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Apple AirTag Kathy – Dental art/sculpture/mobile/chandelier Alan â€...
Source: This Week in Virology - MP3 Edition - April 28, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
