TWiV 893: Yellow fever virus escapes antibodies
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prometheus project (TWiV 578) Reduced neutralization of South American yellow fever virus (Cell Host Microbe) Letters read on TW...
Source: This Week in Virology - MP3 Edition - April 24, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 892: COVID-19 clinical update #111 with Dr. Daniel Griffin
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune response to booster, 5-11 year olds (Pfizer) Children and vaccination (AAP) Hospitalization of 5-11 year olds (MMWR) Test usin...
Source: This Week in Virology - MP3 Edition - April 23, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 891: LLOV in the time of Ebola
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious Lloviu virus from bats in Hungary (Nat Commun) Infectious Lloviu virus from DNA (PloS Path) Letters read on TWiV 891 Timestamps by Jolene...
Source: This Week in Virology - MP3 Edition - April 21, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 890: Looking into a booster crystal ball
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters? (NEJM) Boosting with historical or variant mRNA vaccines (Cell) Vaccination-infection interval determines antibody breadth (Ce...
Source: This Week in Virology - MP3 Edition - April 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospital admissions during Omicron and Delta variant outbreaks (Lancet) Viral load in unvaccinat...
Source: This Week in Virology - MP3 Edition - April 16, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 888: Molnupiravir with Richard Plemper
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in ferrets (Nat Commun) Letters read on TWiV 888 Timestamps by Jolene. Thanks! Weekly Picks Brianne – BioRender Poster Builder A...
Source: This Week in Virology - MP3 Edition - April 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 887: Bonfire of the monocytes
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a dominant H3N2 variant (bioRxiv) Scott Henley on influenza vaccine growth in eggs (TWiV 480) Fc receptor dependent entry of SARS-CoV-2 into ...
Source: This Week in Virology - MP3 Edition - April 10, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 886: COVID-19 clinical update #109 with Dr. Daniel Griffin
In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine does in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cardiac complications after infection or vaccination (MMWR) Long COVID in children (Future Med) Fourth vaccine dose in Israel (NEJM) No need for fourth vaccine dose (Eur Med Agency)...
Source: This Week in Virology - MP3 Edition - April 9, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 885: Russian bats and Ankara vectors
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sarbecovirus from Russian bat (bioRxiv) MVA vectored COVID vaccine (Sci Immunol) Letters read on TWiV 885 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Search for a Model Octopus That Won’t Die After Laying Its Eggs...
Source: This Week in Virology - MP3 Edition - April 7, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 884: Cytokines and viral mimicry
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) SARS-CoV-2 ORF8 mimics IL-17 (mBio) Letters read on TWiV 884 Timestamps by Jolene. Thanks! Weekly Picks Amy – Ben Franklin by Ken Burns Vincent – Thoughts on a second booster: Offit and Krause/Borio Listener Picks Philip –...
Source: This Week in Virology - MP3 Edition - April 3, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 883: COVID-19 clinical update #108 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes second booster (FDA) Second booster and mortality (Res Square) Booster effectiveness vs hospitalization (MMWR) SARS-CoV-2 confections (Lancet) At-home testing (MMWR) Transm...
Source: This Week in Virology - MP3 Edition - April 2, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 882: Elispot on about T cells and lipids
Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Understanding T cell responses during COVID-19 (Science Immunol) IL-1 and IL-1ra are keys to inflammation after RNA vaccination (Nature Immunol) Letters read on TWiV 882 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Covid r...
Source: This Week in Virology - MP3 Edition - March 31, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 881: 50 ways to zap your virus
TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monoclonal antibody provides broad hantavirus protection (Sci Transl Med) Prometheus Project (TWiV 578) Oral antiviral related to Remdesivir (Sci Transl Med) Letters read on TWiV 881 Timestamps by Jolene. Thanks! Week...
Source: This Week in Virology - MP3 Edition - March 27, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 880: COVID-19 clinical update #107 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Moderna vaccin...
Source: This Week in Virology - MP3 Edition - March 26, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 879: Indolent, resistant, and losing our TMPRSS
TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2022 Emergence of remdesivir resistance (Nature Comm) How to stall a copy machine (TWiV 819) Omicron altered TMPRSS2 usage (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – NSURP 20...
Source: This Week in Virology - MP3 Edition - March 24, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
