Reduced efficacy of single-dose albendazole against Ascaris lumbricoides, and Trichuris trichiura, and high reinfection rate after cure among school children in southern Ethiopia: a prospective cohort study
ConclusionAlbendazole MDA is efficacious against hookworm but has reduced efficacy againstA. lumbricoides and is not effective againstT. trichiura. The low drug efficacy and high reinfection rate after cure underscore the need for alternative treatment and integration of other preventive measures to achieve the target of eliminating STHs as a public health problem by 2030.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - January 22, 2024 Category: Infectious Diseases Source Type: research
The burden of intestinal parasitic infections in Antioquia, Colombia: Impact in childhood growth development and nutritional status
Acta Trop. 2024 Mar;251:107119. doi: 10.1016/j.actatropica.2024.107119. Epub 2024 Jan 7.ABSTRACTGastrointestinal protist (GP) and soil-transmitted helminth (STH) infections cause significant morbidity among children in poor-resource settings of tropical and sub-tropical countries including Colombia. Few prospective transversal studies investigating how GP and STH infections affect growth development and nutritional status during childhood have been conducted in this country, none of them in the Antioquia Department. This microscopy-based study estimated the prevalence of GP and helminth (including STH) infections in faecal...
Source: Acta Tropica - January 9, 2024 Category: Infectious Diseases Authors: Carolina Hern ández-Castro Sonia Del Pilar Agudelo-L ópez Ang élica Patricia Medina-Lozano Diego L ópez-García Luis Alfonso Garc ía-Tuberquia Jorge Humberto Botero-Garc és Mar ía Cenelia Orozco-Peláez Manuela Bola ños-Muñoz Daniel Antonio Bejar Source Type: research
Recognition of highly branched N-glycans of the porcine whipworm by the immune system
Mol Cell Proteomics. 2024 Jan 3:100711. doi: 10.1016/j.mcpro.2024.100711. Online ahead of print.ABSTRACTGlycans are key to host-pathogen interactions, whereby recognition by the host and immunomodulation by the pathogen can be mediated by carbohydrate binding proteins, such as lectins of the innate immune system, and their glycoconjugate ligands. Previous studies have shown that excretory-secretory products of the porcine nematode parasite Trichuris suis exert immunomodulatory effects in a glycan-dependent manner. To better understand the mechanisms of these interactions, we prepared N-glycans from T. suis and both analyze...
Source: Molecular and Cellular Proteomics : MCP - January 5, 2024 Category: Molecular Biology Authors: Barbara Eckmair Chao Gao Akul Y Mehta Zuzanna Dutkiewicz Jorick Vanbeselaere Richard D Cummings Katharina Paschinger Iain B H Wilson Source Type: research
Recognition of highly branched N-glycans of the porcine whipworm by the immune system
Mol Cell Proteomics. 2024 Jan 3:100711. doi: 10.1016/j.mcpro.2024.100711. Online ahead of print.ABSTRACTGlycans are key to host-pathogen interactions, whereby recognition by the host and immunomodulation by the pathogen can be mediated by carbohydrate binding proteins, such as lectins of the innate immune system, and their glycoconjugate ligands. Previous studies have shown that excretory-secretory products of the porcine nematode parasite Trichuris suis exert immunomodulatory effects in a glycan-dependent manner. To better understand the mechanisms of these interactions, we prepared N-glycans from T. suis and both analyze...
Source: Molecular and Cellular Proteomics : MCP - January 5, 2024 Category: Molecular Biology Authors: Barbara Eckmair Chao Gao Akul Y Mehta Zuzanna Dutkiewicz Jorick Vanbeselaere Richard D Cummings Katharina Paschinger Iain B H Wilson Source Type: research
Co-infection with malaria and intestinal parasites and its association with anemia in children (zero to ten years old) in tiko subdivision, cameroon
This study determined the prevalence of co-infection with malaria and intestinal parasitic infections and determined its association with anemia in children (0-10 yr) in Tiko, Cameroon. A hospital-based cross-sectional study was carried out whereby venous blood and stool samples were collected from 377 febrile children. Blood was used to perform a full blood count. Thick and thin blood films were prepared and stained with Giemsa for malaria parasite diagnosis. The formol ether concentration technique was used to analyze the stools. Pearson's chi-square test, Student's t-test, and other statistical analyses were performed. ...
Source: The Journal of Parasitology - December 27, 2023 Category: Parasitology Authors: Nicoline Fri Tanih Kemba Iya Belinga Raymond Nyasa Godfred Ngu Tanih Jerome Fru Cho Amidou Samie Anna Longdoh Njunda Source Type: research
Co-infection with malaria and intestinal parasites and its association with anemia in children (zero to ten years old) in tiko subdivision, cameroon
This study determined the prevalence of co-infection with malaria and intestinal parasitic infections and determined its association with anemia in children (0-10 yr) in Tiko, Cameroon. A hospital-based cross-sectional study was carried out whereby venous blood and stool samples were collected from 377 febrile children. Blood was used to perform a full blood count. Thick and thin blood films were prepared and stained with Giemsa for malaria parasite diagnosis. The formol ether concentration technique was used to analyze the stools. Pearson's chi-square test, Student's t-test, and other statistical analyses were performed. ...
Source: The Journal of Parasitology - December 27, 2023 Category: Parasitology Authors: Nicoline Fri Tanih Kemba Iya Belinga Raymond Nyasa Godfred Ngu Tanih Jerome Fru Cho Amidou Samie Anna Longdoh Njunda Source Type: research
Co-infection with malaria and intestinal parasites and its association with anemia in children (zero to ten years old) in tiko subdivision, cameroon
This study determined the prevalence of co-infection with malaria and intestinal parasitic infections and determined its association with anemia in children (0-10 yr) in Tiko, Cameroon. A hospital-based cross-sectional study was carried out whereby venous blood and stool samples were collected from 377 febrile children. Blood was used to perform a full blood count. Thick and thin blood films were prepared and stained with Giemsa for malaria parasite diagnosis. The formol ether concentration technique was used to analyze the stools. Pearson's chi-square test, Student's t-test, and other statistical analyses were performed. ...
Source: The Journal of Parasitology - December 27, 2023 Category: Parasitology Authors: Nicoline Fri Tanih Kemba Iya Belinga Raymond Nyasa Godfred Ngu Tanih Jerome Fru Cho Amidou Samie Anna Longdoh Njunda Source Type: research
Co-infection with malaria and intestinal parasites and its association with anemia in children (zero to ten years old) in tiko subdivision, cameroon
This study determined the prevalence of co-infection with malaria and intestinal parasitic infections and determined its association with anemia in children (0-10 yr) in Tiko, Cameroon. A hospital-based cross-sectional study was carried out whereby venous blood and stool samples were collected from 377 febrile children. Blood was used to perform a full blood count. Thick and thin blood films were prepared and stained with Giemsa for malaria parasite diagnosis. The formol ether concentration technique was used to analyze the stools. Pearson's chi-square test, Student's t-test, and other statistical analyses were performed. ...
Source: The Journal of Parasitology - December 27, 2023 Category: Parasitology Authors: Nicoline Fri Tanih Kemba Iya Belinga Raymond Nyasa Godfred Ngu Tanih Jerome Fru Cho Amidou Samie Anna Longdoh Njunda Source Type: research
Co-infection with malaria and intestinal parasites and its association with anemia in children (zero to ten years old) in tiko subdivision, cameroon
This study determined the prevalence of co-infection with malaria and intestinal parasitic infections and determined its association with anemia in children (0-10 yr) in Tiko, Cameroon. A hospital-based cross-sectional study was carried out whereby venous blood and stool samples were collected from 377 febrile children. Blood was used to perform a full blood count. Thick and thin blood films were prepared and stained with Giemsa for malaria parasite diagnosis. The formol ether concentration technique was used to analyze the stools. Pearson's chi-square test, Student's t-test, and other statistical analyses were performed. ...
Source: The Journal of Parasitology - December 27, 2023 Category: Parasitology Authors: Nicoline Fri Tanih Kemba Iya Belinga Raymond Nyasa Godfred Ngu Tanih Jerome Fru Cho Amidou Samie Anna Longdoh Njunda Source Type: research
Prevalence and Determinants of Geohelminthiasis among School-Age Children in Jimma City, Ethiopia
In conclusion, the study revealed that STH infections are significant health problem in the peri-urban areas of Jimma City. Strengthening periodic deworming and improving children's hygiene through health education are required to reduce the transmission.PMID:38058563 | PMC:PMC10696475 | DOI:10.1155/2023/8811795 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - December 7, 2023 Category: Tropical Medicine Authors: Ahmed Zeynudin Teshome Degefa Sultan Suleman Abdulhakim Abamecha Zuber Hajikelil Andreas Wieser Source Type: research
Near-infrared spectroscopy and machine learning algorithms for rapid and non-invasive detection of Trichuris
by Tharanga N. Kariyawasam, Silvia Ciocchetta, Paul Visendi, Ricardo J. Soares Magalh ães, Maxine E. Smith, Paul R. Giacomin, Maggy T. Sikulu-Lord
BackgroundTrichuris trichiura (whipworm) is one of the most prevalent soil transmitted helminths (STH) affecting 604 –795 million people worldwide. Diagnostic tools that are affordable and rapid are required for detecting STH. Here, we assessed the performance of the near-infrared spectroscopy (NIRS) technique coupled with machine learning algorithms to detectTrichuris muris in faecal, blood, serum samples and non-invasively through the skin of mice. MethodologyWe orally infe...
Source: PLoS Neglected Tropical Diseases - November 13, 2023 Category: Tropical Medicine Authors: Tharanga N. Kariyawasam Source Type: research
Distribution and treatment needs of soil-transmitted helminthiasis in Bangladesh: A Bayesian geostatistical analysis of 2017-2020 national survey data
Conclusions/SignificanceFor each of the STH species, the prevalence was reduced by at least 80% since treatment was scaled up more than a decade ago. The current number of deworming dosages could be reduced by up to 61% if the treatment strategy was adapted to the local prevalence. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 6, 2023 Category: Tropical Medicine Authors: Daniel J. F. Gerber Source Type: research
