Metoprolol Injection (Updated - Currently in Shortage)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 5, 2016 Category: Drugs & Pharmacology Source Type: news

Lopressor Injection (Metoprolol Tartrate Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 21, 2015 Category: Drugs & Pharmacology Source Type: news

Candesartan May Cut Cardiotoxicity in Breast Cancer PatientsCandesartan May Cut Cardiotoxicity in Breast Cancer Patients
Adjuvant candesartan (but not metoprolol) showed "significant but modest" attenuation of LVEF changes after cancer therapy. More research is needed, but "this study is a key first step," notes one expert. Heartwire from Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 12, 2015 Category: Cardiology Tags: Cardiology News Source Type: news

AHA: Candesartan May Preserve Cardiac Function in Breast Ca Patients
(MedPage Today) -- But no difference seen with beta-blocker metoprolol (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 11, 2015 Category: Primary Care Source Type: news

Diltiazem vs Metoprolol for AF With Rapid Ventricular RateDiltiazem vs Metoprolol for AF With Rapid Ventricular Rate
Which of these agents is more effective for the ED management of atrial fibrillation and flutter? A new study compares the efficacy. The Journal of Emergency Medicine (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - September 16, 2015 Category: Emergency Medicine Tags: Emergency Medicine Journal Article Source Type: news

Podcast: Managing the crashing tox patient with ECMO
As I wrote about in a recent column for Emergency Medicine News, extracorporeal membrane oxygenation (ECMO) may be the next big thing in managing the severely ill, crashing overdose patient in whom usual therapy is not working. On the new podcast posted today at the EDECMO website, Steve Aks and I got together over Skype with Joe Bellezzo, Zack Shinar, and Scott Weingart to discuss the potential benefits, as well as the potential risks and complications, involved in using ECMO in the sickest tox patients. Some of the topics we discuss: What overdose patients might benefit most from ECMO? What vascular access is neede...
Source: The Poison Review - June 16, 2015 Category: Toxicology Authors: Leon Tags: Medical ECMO edecmo extracorporeal membrane oxygenation podcast poisoning toxicology Source Type: news

Excellent review of lipid rescue therapy
3.5 out of 5 stars Intravenous Lipid Emulsion in the Emergency Department: A Systematic Review of Recent Literature. Cao D et al. J Emerg Med 2014 Dec 19 [Epub ahead of print] Abstract This excellent comprehensive review of lipid rescue therapy (LRT) is vitiated only by the unavoidable fact that available clinical evidence  is so inconclusive. As the authors point out, published literature consists mostly of case reports and small case series. The vast majority of these reported cases have good outcomes and reflect positive effects from ILE, but the evidence is marred by multiple confounding variables (such ...
Source: The Poison Review - February 26, 2015 Category: Toxicology Authors: Leon Tags: Medical intralipid lipid emulsion lipid rescue therapy lipid sink Review Source Type: news

FDA Recalls Another Batch of Generic Metoprolol (FREE)
By Larry Husten Edited by David G. Fairchild, MD, MPH, and Richard Saitz, MD, MPH, FACP, FASAM The FDA has recalled more than 13,000 bottles of metoprolol succinate extended-release tablets manufactured by Dr. Reddy's Laboratories, Reuters reported late last … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 25, 2014 Category: Primary Care Source Type: news

FDA Recalls Another Batch Of Generic Metoprolol
The FDA has recalled more than 13,000 bottles of metoprolol succinate extended release tablets manufactured by Dr. Reddy's Laboratories. Two months ago the agency recalled another lot of generic metoprolol from a different company, Wockhardt. Both recalls were for medicines manufactured at facilities in India. There have been multiple reports in recent years of problems with generic drugs made in India. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 24, 2014 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

Generic Versions of Toprol XL, a Heart Drug, Are Recalled
Recalls by two large Indian manufacturers, Wockhardt and Dr. Reddy’s Laboratories, are the latest in a string of recent problems involving generic drugs. (Source: NYT Health)
Source: NYT Health - June 24, 2014 Category: Consumer Health News Authors: By KATIE THOMAS Tags: India Drugs (Pharmaceuticals) Food and Drug Administration Dr Reddys Laboratories Ltd RDY NYSE Recalls and Bans of Products Novartis AG NVS NYSE Source Type: news

India Generic Blood Pressure Drugs Recalled Again in U.S.
India's Dr Reddy's Laboratoriesis recalling 13,560 bottles of the high blood pressure drug metoprolol succinate in the United States after the drug failed a dissolution test. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - June 19, 2014 Category: Pharmaceuticals Source Type: news

Dr Reddy's recalls over 13,000 bottles of hypertension drug: FDA
Dr Reddy's Laboratories Ltd is recalling 13,560 bottles of the high blood pressure drug metoprolol succinate in US after it failed a dissolution test. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 19, 2014 Category: Pharmaceuticals Source Type: news

Dr Reddy's recalls over 13,000 bottles of hypertension drug- FDA
MUMBAI (Reuters) - India's Dr Reddy's Laboratories Ltd is recalling 13,560 bottles of the high blood pressure drug metoprolol succinate in the United States after it failed a dissolution test, the U.S. Food and Drug Administration said. (Source: Reuters: Health)
Source: Reuters: Health - June 19, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Wockhardt recalls 8,712 bottles of hypertension drug in US market
Wockhardt is recalling over 8,000 bottles of anti-hypertension drug Metoprolol Succinate extended-release tablets following failure of a dissolution test. (Source: The Economic Times)
Source: The Economic Times - June 5, 2014 Category: Consumer Health News Source Type: news

India's Wockhardt Recalls Generic Heart Pills
Mumbai-based Wockhardt is recalling 109,744 bottles of its generic version of AstraZeneca's hypertension drug Toprol XL in the U.S. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - May 15, 2014 Category: Pharmaceuticals Source Type: news

FDA Planning Study of Generic Metoprolol Over Safety, Efficacy Concerns (FREE)
Extract The FDA is planning an in-depth study of generic extended-release metoprolol succinate after receiving nearly 3500 complaints related to the blood pressure drug... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 9, 2014 Category: Primary Care Source Type: news

Do two dissimilar cases represent a case series?
2 out of 5 stars High-dose Insulin and Intravenous Lipid Emulsion Therapy for Cardiogenic Shock Induced by Intentional Calcium-Channel Blocker and Beta-Blocker Overdose: A Case Series. Doepker B et al. J Emerg Med 2014 Apr;46:486-490.   Abstract The problems with this confused and confusing paper start with the title, which suggests that it will describe a series patients who presented with overdose of a calcium-channel blocker (CCB) and beta-blocker (BB), who were treated with high-dose insulin (HDI) and intravenous lipid emulsion (ILE). Well, this may be a case series, but the series includes only 2 patien...
Source: The Poison Review - April 3, 2014 Category: Toxicology Authors: Leon Tags: Medical beta blocker overdose calcium channel blocker overdose high-dose insulin intralipid intravenous fat emulsion Source Type: news

Benefits of treating heart attack patients with a cheap drug
One dose of the drug metoprolol, if given to heart attack patients early -- during ambulance transit to hospital -- can significantly improve the contractile strength of the heart muscle. And this improvement is maintained for at least six months after the intervention, according to new results. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 31, 2014 Category: Science Source Type: news

Asystole shortly after intravenous fat emulsion for overdose: causation or coincidence?
3 out of 5 stars Asystole Immediately Following Intravenous Fat Emulsion for Overdose. Cole JB et al. J Med Toxicol 2014 Feb 12. [Epub ahead of print] Abstract This case paper describes 2 patients who developed asystolic within 60 seconds of being given intravenous fat emulsion (IFE) bolus for treatment of severe cardiotoxicity. Both patients had return of spontaneous circulation (ROSC) after several minutes of cardiopulmonary resuscitation. Unfortunately, both patients died days after admission from multisystem organ failure. Patient A,  a 50-year-old woman, had ingested an undetermined about of metoprolol and b...
Source: The Poison Review - February 18, 2014 Category: Toxicology Authors: Leon Tags: Medical asystole bupropion cardiac arrest diltiazem intralipid intravenous fat emulsion therapy metoprolol propranolol Source Type: news

Wockhardt’s Main Drug Plant Added to FDA's "Red List"
The plant makes generic of Toprol-XL, a heart pill that accounts for about 14 percent of its sales (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - December 2, 2013 Category: Pharmaceuticals Source Type: news

Cardio Notes: IV Beta-Blocker Early on Shrinks Infarcts
(MedPage Today) -- The METOCARD-CNIC trial showed that intravenous metoprolol before patients go to the cath lab could have some benefit. Also, group heart failure appointments satisfied patients and office staff alike. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - October 7, 2013 Category: Consumer Health News Source Type: news

Cardio Notes: IV Beta-Blocker Given Early Shrinks Infarcts
(MedPage Today) -- The METOCARD-CNIC trial showed that intravenous metoprolol before patients go to the cath lab could have some benefit. Also, group heart failure appointments satisfied patients and office staff alike. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - October 7, 2013 Category: Cardiology Source Type: news

Inexpensive drug costing less than 3 dollars may minimize damage from heart attack
(The Mount Sinai Hospital / Mount Sinai School of Medicine) Early treatment of heart attack patients with an inexpensive beta-blocker drug called metoprolol, while in transit to the hospital, can significantly reduce damage to the heart during a myocardial infarction. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 1, 2013 Category: Global & Universal Source Type: news

CNIC researchers minimize damage during a heart attack with a drug costing less than €2.00
(Centro Nacional de Investigaciones Cardiovasculares) Early treatment--during ambulance or helicopter transit to the hospital--with metoprolol, a cheap drug available for more than 30 years, significantly reduces damage to the heart during a myocardial infarction, according to the results of the METOCARD-CNIC study published in the latest edition of Circulation, the leading journal in the cardiovascular field. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 1, 2013 Category: Global & Universal Source Type: news

Carvedilol superior to metoprolol in MADIT-CRT analysis
The benefit of carvedilol over metoprolol was more pronounced in the subgroup of patients with a CRT-D, where carvedilol was associated with a significant 39% reduction in the risk of hospitalization for HF or death, and in those with left bundle branch block. (Source: theHeart.org)
Source: theHeart.org - April 2, 2013 Category: Cardiology Source Type: news

Carvedilol Beats Metoprolol in Some HF Patients (CME/CE)
(MedPage Today) -- Patients with mild heart failure and an implanted CRT-D device to regulate heart rhythm appear to do better with the beta-blocker carvedilol than with metoprolol, a subanalysis of MADIT-CRT suggested. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 2, 2013 Category: Cardiology Source Type: news

RCT: Metoprolol vs carvedilol, or carvedilol plus N-acetylcysteine on post-operative atrial fibrillation
Source: Eur Heart J Area: News The aim of this study was to evaluate the efficacy of metoprolol, carvedilol, and carvedilol plus NAC on the prevention of post-operative atrial fibrillation (POAF).   Three hundred and eleven patients undergoing cardiac surgery were randomised to metoprolol, carvedilol, or carvedilol plus NAC. The incidence of POAF was statistically lower in the carvedilol plus NAC group compared with the metoprolol group (P
Source: NeLM - Cardiovascular Medicine - February 22, 2013 Category: Cardiology Source Type: news

Metoprolol Succinate vs Ivabradine in Sinus TachycardiaMetoprolol Succinate vs Ivabradine in Sinus Tachycardia
Which agent is more favorable for inappropriate sinus tach? Europace (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 23, 2013 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Benefits of beta blockers in patients with heart failure and reduced ejection fraction: network meta-analysis
Source: BMJ Area: News Beta blockers have been shown in randomised trials to prolong survival, prevent arrhythmia, improve symptoms of heart failure and left ventricular ejection fraction, and control ventricular rate, especially in patients with chronic heart failure. However, controversy exists as to the optimal selection of a particular agent for management of heart failure, as they differ in their selectivity for adrenergic receptors and their effects on the peripheral circulation.   This systematic review and network meta-analysis was conducted of efficacy of different beta- blockers in heart failure to clar...
Source: NeLM - Cardiovascular Medicine - January 17, 2013 Category: Cardiology Source Type: news

Elderly female with CHF complains of abdominal pain, nausea and vomiting, dizziness, and confusion for 5 days due to digoxin toxicity
Author: V. Dimov, M.D.Reviewer: S. Randhawa, M.D.Click here for thecase description and questions.What is the most likely diagnosis?Digoxin toxicity.Laboratory resultsFigure 1. Digoxin toxicity. Treatment with digoxin was started in the hospital and the patient was discharged to SNF, she was re-admitted 4 days later with digoxin toxicity.What would you do?Stop digoxin.Monitor digoxin levels.Control symptoms.Sitter in the room.What happened?The initial digoxin level was elevated at nearly twice the upper therapeutic level. All symptoms resolved as digoxin level decreased to therapeutic range. Heart rate was controlled by in...
Source: Clinical Cases and Images - August 2, 2009 Category: General Medicine Tags: Cardiology Intensive Care Toxicology Source Type: news