Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Results from a Trial of the Senolytic Fisetin in a Single Individual with Autoimmunity
Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
Source: Fight Aging! - November 30, 2021 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming.
In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs
The Art of Asking: What Else is Going on?
By HANS DUVEFELT
Walter Brown’s blood sugars were out of control. Ellen Meek had put on 15 lbs. Diane Meserve’s blood pressure was suddenly 30 points higher than ever before.
In Walter’s case, he turned out to have an acute thyroiditis that caused many other symptoms that came to light during our standard Review of Systems.
Ellen, it turned out, was pretty sure her husband was having an affair with one of his coworkers. And, since this wasn’t the first time, she was secretly working on a plan to move out and file for divorce. She admitted she’d always had a tendency to stress eat.
Diane’s daughter h...
Source: The Health Care Blog - March 15, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Primary Care Hans Duvefelt health communication Source Type: blogs
Clinical Depth: The Power of Knowing More than the Minimum
By HANS DUVEFELT, MD
In medicine, contrary to common belief, it is not usually enough to know the diagnosis and its best treatment or procedure. Guidelines, checklists and protocols only go so far when you are treating real people with diverse constitutions for multiple problems under a variety of circumstances.
The more you know about unusual presentations of common diseases, the more likely you are to make the correct diagnosis, I think everyone would agree. Also, the more you know about the rare diseases that can look like the common one you think you’re seeing in front if you, rather than having just a memorize...
Source: The Health Care Blog - November 6, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Primary Care Hans Duvefelt primary care physicians Source Type: blogs
Is there a role for surgery in treating Hashimoto ’s thyroiditis?
This study raises the possibility of a role for surgery for patients with Hashimoto’s thyroiditis who continue to feel poorly despite optimal treatment with thyroid hormone.
However, the study, while well done, is a relatively small one. We need longer-term follow up and confirmation with additional studies done on diverse populations.
It’s also important to consider that thyroid surgery in patients with advanced Hashimoto’s thyroiditis is difficult. Rates of complications, including injury to the laryngeal nerve (which controls voice) and the parathyroid glands (which maintain normal blood calcium levels), are incre...
Source: Harvard Health Blog - August 12, 2019 Category: Consumer Health News Authors: Jeffrey Garber, MD, FACP, FACE Tags: Health Thyroid Disorders Source Type: blogs
Autoimmune Disease: Start With Wheat & Grain Elimination
If you or someone close to you have an autoimmune condition such as rheumatoid arthritis, lupus, Hashimoto’s thyroiditis, Crohn’s disease or ulcerative colitis, along with about 195 others, there are a number of steps you can take that reduce, even eliminate the autoimmune inflammation damaging your organs. (Unfortunately, some forms of autoimmune damage cannot be reversed. Autoimmune loss of pancreatic beta cells that lead to type 1 diabetes, Hashimoto’s thyroiditis that damages the thyroid gland, or autoimmune hepatitis that can lead to cirrhosis. for example, cannot be reversed even if the autoimmune p...
Source: Wheat Belly Blog - June 23, 2019 Category: Cardiology Authors: Dr. Davis Tags: Autoimmunity autoimmune casein Gliadin grain-free omega-3 undoctored vitamin D wheat belly Source Type: blogs
Thyroid Tune-Up
I am re-posting a classic Wheat Belly Blog post from a few years ago. Despite all our discussions about thyroid issues, there continues to be an enormous information gap: undiagnosed hypothyroidism, gross mismanagement sufficient to impair weight loss and increase cardiovascular risk, dismissing the importance of iodine, and ignorance among healthcare providers. This Thyroid Tune-up is therefore an updated version of the previous post.
Imagine that all the cars in your neighborhood run poorly because nobody bothers to tune-up their autos. I show you how to tune the cars and, lo and behold, 80% of the cars now run great. B...
Source: Wheat Belly Blog - January 6, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune gluten-free grain-free grains hypothyroid levothyroxine Synthroid Source Type: blogs
The Horrors of Gluten-Free Food
It continues to happen: I run into people who say to me “I follow the Wheat Belly lifestyle. I eat gluten-free!” When I ask them what that means, they tell me that they only eat gluten-free bread, pasta, pizza, cookies, etc.
I’m not entirely sure why this misinterpretation of the Wheat Belly message is so common. Let’s talk about this important distinction, as being gluten-free can be an absolute health and weight disaster, unlike the magnificent health and weight loss we enjoy on the Wheat Belly lifestyle when done right.
It’s perfectly fine to be gluten-free, i.e., avoiding wheat, rye, and b...
Source: Wheat Belly Blog - December 5, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune blood sugar gluten gluten-free grain grain-free grains Weight Loss wheat belly Source Type: blogs
The Wheat Belly Timeline: The First Few Weeks
With all our talk of opiate withdrawal syndromes accompanied by nausea, headache, fatigue, and depression, it can be daunting, even terrifying, to people who face the prospect of tossing all wheat and grains into the trash bin, vowing to never let a Danish, donut, or dish of pasta cross your lips again. So it may help to lay out a timeline of what and when various changes can develop in the Wheat Belly wheat- and grain-free lifestyle.
You can expect different symptoms and health conditions to recede at different rates, since they are caused by a variety of different mechanisms. For instance, the direct gastrointestinal tox...
Source: Wheat Belly Blog - October 26, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle acid reflux detoxification grains IBS Inflammation joint pain opiates withdrawal Source Type: blogs
Track Your Wheat Belly Transformation
Health, weight, and appearance are transformed by living the Wheat Belly lifestyle. You can see it on the face with reduced puffiness and edema and smoother skin. You can see it on the waistline as inflammatory visceral fat recedes. You can perceive it as increased energy, reduced depression and anxiety, reduction or elimination of irritable bowel syndrome and acid reflux symptoms, reduced joint pain, reversal of leg/ankle edema, and in so many other ways.
But how about blood measures of health? You can witness the transformations there, too. And the transformations you see in blood markers of health can be just as dramati...
Source: Wheat Belly Blog - September 20, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates cholesterol Inflammation triglycerides Weight Loss wheat belly Source Type: blogs
Irreversible
Follow the Wheat Belly lifestyle and literally hundreds of diseases can be reversed: type 2 diabetes reverts to normal within weeks to months (depending on how much weight needs to be lost to restore insulin sensitivity), fatty liver reverses to normal within a few weeks, skin rashes recede, IBS and acid reflux are gone within days in the majority, high triglycerides plummet, even several forms of kidney disease can reverse.
But there are health conditions that, once established, can leave effects that can be irreversible even if the initial causative condition reverses. For example, type 2 diabetes can cause kidney damag...
Source: Wheat Belly Blog - August 6, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune Gliadin gluten gluten-free grain-free grains Inflammation undoctored wheat belly Source Type: blogs
Eponymythology: Graves orbitopathy
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Having recently reviewed the chronology of diffuse toxic goitre (Parry-Graves-Basedow disease) we tackle the chronological descriptions behind Graves orbitopathy (GO).
Why? Well, I’m still working that out. But I think that in our KPI-driven quest for diagnostic certainty, we have forgotten the descriptive pioneers – the clinical diagnosticians.
Time to review the descriptions and eponymythology of the forgotten signs associated with Graves orbitopathy ̵...
Source: Life in the Fast Lane - February 12, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Eponymythology Dalrymple sign Graefe sign Graves Opthalmopathy Graves orbitopathy Joffroy sign Möbius sign stellwag sign Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
The Dangers of Carb Loading
Carb loading is viewed as an essential practice by people who engage in vigorous exercise. But it is a practice that can lead, over time, to disastrous health consequences, including heart disease, dysbiosis, and fatty liver.
And it is also entirely unnecessary, a dietary mistake created by a misinterpretation of scientific studies conducted 70 -80 years ago.
About Undoctored:
We are entering a new age in which the individual has astounding power over health–but don’t count on the doctor or healthcare system to tell you this.
We draw from the health information of the world, collaborate, share experiences, coll...
Source: Wheat Belly Blog - December 1, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle gluten gluten-free grain-free grains Inflammation low-carb Source Type: blogs
