Eponymythology: Graves orbitopathy

LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Having recently reviewed the chronology of diffuse toxic goitre (Parry-Graves-Basedow disease) we tackle the chronological descriptions behind Graves orbitopathy (GO). Why? Well, I’m still working that out. But I think that in our KPI-driven quest for diagnostic certainty, we have forgotten the descriptive pioneers – the clinical diagnosticians. Time to review the descriptions and eponymythology of the forgotten signs associated with Graves orbitopathy  – the signs of Dalrymple, Stellwag, von Graefe, Möbius and Joffroy… Background It is no surprise that historically, semantic confusion reigns regarding Graves orbitopathy. .. An interchangeable array of terms ranging from thyroid eye disease (TED) and thyroid-related ophthalmopathy (TRO) to dysthyroid/euthyroid/infiltrative/Graves ophthalmopathy; thyrotoxic/malignant/endocrine exophthalmos; exophthalmos of endocrine origin; and thyroid ophthalmopathy/orbitopathy have been used to describe ophthalmic signs that may accompany Graves disease, hypothyroidism, or Hashimoto thyroiditis. Graves orbitopathy, thyroid dermopathy (pretibial myxedema) and acropachy are the extrathyroidal manifestations of Graves disease. They occur in 25%, 1.5% and 0.3% of patients with Graves disease respectively. Graves orbitopathy is the commonest extrathyroidal manifestati...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Eponymythology Dalrymple sign Graefe sign Graves Opthalmopathy Graves orbitopathy Joffroy sign Möbius sign stellwag sign Source Type: blogs