Role of aminopeptidase N ‐like in the acquisition of begomoviruses by Bemisia tabaci, the whitefly vector
In this study, we identified an aminopeptidase N-like protein (BtAPN) inB. tabaci Asia II 1, an efficient vector of SLCMV, which is involved in the SLCMV transmission process. Through the use of glutathione S-transferase pull-down assay and LC-MS/MS analysis, we demonstrated the interaction between BtAPN and the coat protein (CP) of SLCMV. This interaction was further confirmedin vitro, and we observed an induction ofBtAPN gene expression following SLCMV infection. By interfering with the function of BtAPN, the quantities of SLCMV were significantly reduced in various parts ofB. tabaci Asia II 1, including the wh...
Source: Insect Science - February 19, 2024 Category: Biology Authors: Yun ‐Yun Fan,
Yao Chi,
Na Chen,
Wilmer J. Cuellar,
Xiao‐Wei Wang Tags: ORIGINAL ARTICLE Source Type: research
Bruns Garland Syndrome as the first presentation of type 2 diabetes: two case reports and a practical approach to diagnosis
ConclusionDiagnosis of diabetic radiculoplexus neuropathy requires a comprehensive workup to rule out other sinister pathologies. This case report has a dual importance; it describes diabetic radiculoplexus neuropathy as the very first manifestation of two previously healthy people, giving rise to a new diagnosis of diabetes and, at the same time, reporting on diabetic cervical radiculoplexus neuropathy, which is extremely rare and has never been previously reported in Sri Lanka. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 16, 2024 Category: General Medicine Source Type: research
In vitro growth of Leishmania parasites from biopsy samples of suspected cutaneous and visceral leishmaniasis cases in Sri Lanka: An observational study
Exp Parasitol. 2024 Feb 11:108710. doi: 10.1016/j.exppara.2024.108710. Online ahead of print.ABSTRACTSri Lanka reports a large focus of Leishmania donovani caused cutaneous leishmaniasis (CL). Subsequent emergence of visceral leishmaniasis (VL) was also reported recently. Expansion of the on-going disease outbreak and many complexities indicate urgent need to enhance early case detection methods. In vitro cultivation (IVC) of parasites causing visceral leishmaniasis (VL) is important for disease confirmation and to obtain sufficient quantities of parasites required in many scientific studies. IVC is carried out as a useful...
Source: Experimental Parasitology - February 13, 2024 Category: Parasitology Authors: Bhagya Deepachandi Sudath Weerasinghe Himali Gunathileka Preethi Soysa Yamuna Siriwardana Source Type: research
Multifunctionality benefits of small-scale urban agriculture
AbstractDue to the scarcity of land, small-scale agriculture farming is more suitable in the urban context. But there are significant knowledge gaps that remain regarding small-scale urban food production systems, especially, in developing countries. Hence, this study was carried out to investigate the farmers ’ perception of the multifunctional benefits of small-scale urban agriculture activities in Sri Lanka and the factors determining (demographic, farm management, and economic) those perceptions. A perception survey was conducted for 402 small-scale farmers in Colombo District, Sri Lanka. Ordinal re gression was appl...
Source: Sustainability Science - February 8, 2024 Category: Science Source Type: research
Efficacy and safety of deferoxamine, deferasirox and deferiprone triple iron chelator combination therapy for transfusion-dependent {beta}-thalassaemia with very high iron overload: a protocol for randomised controlled clinical trial
Introduction
Despite the improvement in medical management, many patients with transfusion-dependent β-thalassaemia die prematurely due to transfusion-related iron overload. As per the current guidelines, the optimal chelation of iron cannot be achieved in many patients, even with two iron chelators at their maximum therapeutic doses. Here, we evaluate the efficacy and safety of triple combination treatment with deferoxamine, deferasirox and deferiprone over dual combination of deferoxamine and deferasirox on iron chelation in patients with transfusion-dependent β-thalassaemia with very high iron overload.
Metho...
Source: BMJ Open - February 8, 2024 Category: General Medicine Authors: Premawardhena, A., Perera, C., Wijethilaka, M. N., Wanasinghe, S. K., Rajakaruna, R. H. M. G., Samarasinghe, R. A. N. K. K., Williams, S., Mettananda, S. Tags: Open access, Haematology (incl blood transfusion) Source Type: research
Breeding Habitat Preference of the Dengue Vector Mosquitoes < em > Aedes aegypti < /em > and < em > Aedes albopictus < /em > from Urban, Semiurban, and Rural Areas in Kurunegala District, Sri Lanka
J Trop Med. 2024 Jan 29;2024:4123543. doi: 10.1155/2024/4123543. eCollection 2024.ABSTRACTElimination of vector mosquito larvae and their breeding environments is an effective strategy in dengue disease control. Present study examined larval density and water quality in breeding habitats and container preference of dengue vectors Ae. aegypti and Ae. albopictus. Larval surveys were conducted monthly in urban, semiurban, and rural sites in Kurunegala, Sri Lanka, from January 2019 to December 2021. Larval densities were recorded under the following three categories: type of container (16 types), type of material (6 types), an...
Source: Journal of Tropical Medicine - February 6, 2024 Category: Tropical Medicine Authors: J M Manel K Herath W A Priyanka P De Silva Thilini C Weeraratne S H P Parakrama Karunaratne Source Type: research
Prevalence of growth hormone receptor gene polymorphisms and their association with milk production and fertility-related traits of cross-bred dairy cows in Sri Lanka
This study investigated the association of selected growth hormone receptor (GHR) gene SNPs with selected fertility and milk production-related phenotypes of cross-bred dairy cows (n = 153) reared on three National Livestock Development Board farms in Sri Lanka. Selected cows were genetically screened for SNPs in the exon 08 (n = 153) and 5' upstream (n = 118) regions of the GHR gene using the target sequencing method. The relationships between different genotypes and fertility traits (average calving interval, average number of services per conception, and age at first calving) and milk production-related traits (average ...
Source: Animal Biotechnology - February 2, 2024 Category: Biotechnology Authors: Dameesha Indeewari Abeygunawardana Ranasinghe Mudiyanselage Sajeewani Bimalka Kumari Ranasinghe Sembukuttige Nimali Tharangani De Silva Rathnayake Mudiyanselage Chandrasiri Deshapriya Prathapasinghe Arachchige Gamika Jayanthe Rajapakse Source Type: research
Optimization of standard zircon U –Pb dating: insights into high-temperature thermal annealing
J. Anal. At. Spectrom., 2024, Advance Article DOI: 10.1039/D3JA00407D, PaperMingpu Fan, Xiaoming Liu, Shengsi Sun, Yunpeng Dong, Zhian Bao The weighted average206Pb/238U ages for unannealed and annealed Ple šovice zircons (photomicrographs are shown in (a) and (b)) using LA-ICP-MS are shown in (c) and (d) and Sri Lanka zircons using SIMS are shown in (e) and (f). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Anal. At. Spectrom. latest articles)
Source: RSC - J. Anal. At. Spectrom. latest articles - January 30, 2024 Category: Chemistry Authors: Mingpu Fan Source Type: research
Polyphenol Mediated Suppression of Hepatocellular Carcinoma (HepG2) Cell Proliferation by Clerodendrum infortunatum L. Root
CONCLUSION: The obtained result of the present study demonstrates that the antioxidant potential and antiproliferative activity of AECIR is attributed to the presence of polyphenols. Furthermore, the findings provide the scientific base for anti-cancer potential of AECIR.PMID:38285803 | DOI:10.31557/APJCP.2024.25.1.351 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - January 29, 2024 Category: Cancer & Oncology Authors: Imali Ranatunge Preethi Soysa Source Type: research
