Increasing Opportunities in STEM at Brown University and Beyond
Credit: Courtesy of Brown University. Andrew G. Campbell, Ph.D., a professor of medical science at Brown University in Providence, Rhode Island, and previous dean of the graduate school, is passionate about researching understudied diseases and helping students reach their full potential. Dr. Campbell’s lab has studied the single-cell organism Trypanosoma brucei (T. brucei), a parasite transmitted through the bite of the tsetse fly, which is only found in specific regions of Africa. In humans, T. brucei causes African Trypanosomiasis, also known as sleeping sickness. Symptoms of this illness include headache, weakne...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 7, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Training Source Type: blogs

Advocating for Epigenetic Reprogramming as a Potential Rejuvenation Therapy
Partial epigenetic reprogramming emerges from the intersection of understanding how cells behave in cancerous tissue and during embryonic development. In the developing embryo there is a point at which adult germline cells convert themselves into embryonic stem cells, discarding forms of damage and dysfunction characteristic of adult cells and restoring a youthful pattern of the epigenetic markers attached to the genome that control its shape in the cell nucleus and thus gene expression. Some of the genes involved are known to also operate in cancers, in which replication and reprogramming runs wild, but which use many of ...
Source: Fight Aging! - February 6, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What ’ s a link shortener, anyway?
I posted a survey about the likelihood of users clicking a charity or fundraising link that had been shortened with a tool like tinyURL, bit.ly or j.mp, or buff.ly. To my surprise, there was a comment from one follower telling me that he didn’t know what a link shortener was. Well, link shorteners are online tools that convert long website addresses, (URLs) into shorter, more manageable links. These shortened URLs redirect users to the original, longer URL when clicked. Many sites, like Amazon, Twitter, Wikipedia, and Youtube, have link shorteners to allow you to copy and share a shortened version of an internal link...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 6, 2024 Category: Science Authors: David Bradley Tags: Social Media Source Type: blogs

A teenager involved in a motor vehicle collision with abnormal ECG
Written by Pendell MeyersA teenager was involved in a motor vehicle collision and presented to the Emergency Department via EMS altered and potentially critically ill. He was intubated for altered mental status. Chest trauma was suspected on initial exam. Here is his initial ECG around 1330:What do you think?The ECG shows sinus tachycardia with RBBB and LAFB, without clear additional superimposed signs of ischemia. It is very unlikely that a previously healthy teenager would have such disease of the conduction system, bringing up the possibility of blunt cardiac injury in this clinical setting.Trauma CTs showed a " mi...
Source: Dr. Smith's ECG Blog - February 6, 2024 Category: Cardiology Authors: Pendell Source Type: blogs

An Interview with Karl Pfleger
Karl Pfleger is one of the more prolific angel investors in the longevity industry. Naturally he is an investor in Repair Biotechnologies, the company that I co-founded with Bill Cherman and which is currently focused on a gene therapy approach to reversal of atherosclerosis. In addition to his investment and conference-going activities, Pfleger runs the very useful Aging Biotech Info resource, which has expanded from the starting point of a list of companies in the longevity industry to its present state of listing of a great many more items: conferences, books, blogs, interventions, diagnostics, and so forth. In the podc...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Reimagining the Seedballs
I’ve mentioned Seedball a few times previously. The team has very generously sent me samples of their product, which offers a novel way to rewild your garden, or indeed, any outdoor space, without the need to handle thousands of tiny seeds. The balls themselves act as a growth medium within which the seeds for any of dozens wildflowers can be held. You simply scatter the seed balls on your patch and water in. Hummingbird Hawk-moth nectaring on Red Valerian In time, the seeds germinate and your patch is converted into a wonderland of wildflowers and almost immediately starts benefiting the local invertebrate community...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 5, 2024 Category: Science Authors: David Bradley Tags: AllotmentLife Invertebrates Lepidoptera PondLife Source Type: blogs

Decoding digestive discomfort: the science behind FODMAPs
FODMAPs are Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols. Digestive discomfort – excessive flatulence, “bloating”, loose stool, or constipation – is a prevalent issue for many, and it often finds its roots in a group of fermentable carbohydrates collectively known as FODMAPs. Understanding the science behind FODMAPs could help in establishing a more comfortable and gratifying relationship with food. In the realm of our digestive system, envision a system akin to an intricate ecosystem, teeming with activity. Various nutrients act as its constituents, powering this intern...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 5, 2024 Category: Science Authors: David Bradley Tags: Food Health and Medicine Source Type: blogs

DecisionRx Announces $100 Million Credit Facility with Carlyle
Funds to Support Delivery of DecisionRx’s Comprehensive Medication Therapy Optimization Program DecisionRx, Inc., a value-based healthcare company reducing the cost of care by helping physicians eliminate medication failure, today announced that it has entered into a $100 million credit facility with global investment firm Carlyle. The financing will support the cost-bearing that is key to DecisionRx’s unique business model:  DecisionRx can assume the full cost of delivering Medication Therapy Optimization to patients of Accountable Care Organizations, Medicare Advantage Plans, and self-insured employers. The facility...
Source: EMR and HIPAA - February 5, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Akhil Bansal Aon Aon Securities Carlyle DecisionRx Health IT Funding Health IT Fundings Health IT Investment James Wallace Sourna Daneshvar Source Type: blogs

You Can Be sure This Is Just The Beginning Of What Will Be Possible In Years To Come.
 This appeared a few days ago: Gene therapy hailed as ‘medical magic wand’ for hereditary swelling disorder Single-dose treatment transformed lives of patients with potentially deadly condition in first human trial Medical research Ian Sample Science editor @iansample Thu 1 Feb 2024 09.00 AEDT A groundbreaking gene therapy has been hailed as a “medical magic wand” after the treatment (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - February 5, 2024 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Not New Year 2024 in Titchwell and Holkham
We didn’t make it to the north Norfolk coast for our usual new year yomp through the area, but we did make it to Titchwell for a couple of nights a month later. We had packed and departed for the coast by mid-afternoon. As we approached our lodgings, it was almost dark, a shadowy Tawny Owl flew across our path. By the time we arrived, it was fully dark and the last of the day’s Brent and Pink-footed Geese were noisily heading to roost. Shore Lark, one of 14 in a flock at Holkham Gap We ate well that evening at Briarfields and the next day we were up reasonably early to see Marsh Harriers quartering the eastern...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 4, 2024 Category: Science Authors: David Bradley Tags: Birds Source Type: blogs

Gene therapy breakthroughs: a new era in genetic disorder treatment
In a significant leap forward for medical science, recent breakthroughs in gene therapy are ushering in a new era of treatment for various human diseases. The field of gene therapy, which involves manipulating or introducing genetic material into a person’s cells to treat or prevent disease, has seen remarkable advancements, with several gene therapy drugs Read more… Gene therapy breakthroughs: a new era in genetic disorder treatment originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 4, 2024 Category: General Medicine Authors: Tags: Meds Oncology/Hematology Source Type: blogs

GRCr8: A new rat reference assembly is released!
GRCr8 (GCA_036323735.1), the latest version of the rat reference genome assembly, is now available. GRCr8 is an evolution of mRatBN7.2 (GCA_015227675.2), the Vertebrate Genomes Project-generated rat assembly that was the first reference for this species to be adopted by the GRC for stewardship. mRatBN7.2 was an assembly of a Brown Norway (BN) male rat from the same colony at the Medical College of Wisconsin that supplied the female rat used in the 2004 RGSC_v3.4 assembly (AABR00000000.3/GCF_000001895.1). While the assembly of mRatBN7.2 was a substantial improvement over prior versions (https://pubmed.ncbi.nlm.nih.gov/37214...
Source: GenomeRef - February 2, 2024 Category: Genetics & Stem Cells Source Type: blogs

The Science of Happiness: Proven Habits for a Fulfilling Life
The majority of Americans are not experiencing much happiness these days. According to a poll, only 19% of the surveyed individuals described themselves as "very happy." Other comparable studies also demonstrated low happiness ratings. While not entirely surprising given the turbulent economy and other concerns, these insights reveal that many people are not reaping the benefits of daily fulfillment. Happiness has long been associated with numerous personal and familial benefits. When we are happy, we are less likely to be burdened by the devastating effects of stress, such as an increased risk of developing cardiovascu...
Source: PickTheBrain | Motivation and Self Improvement - January 31, 2024 Category: Consumer Health News Authors: Mike Szczesny Tags: depression featured happiness philosophy self improvement Source Type: blogs

Putting West Virginia Students on the Path to Scientific Careers
Credit: NIGMS. Two NIGMS-funded programs are teaming up to shape the future of science and technology in West Virginia (WV). One engages high school students in science, technology, engineering, math, and medicine (STEM+M); introduces them to research; and provides direct access to college through tuition waivers. In the other program, undergraduate students are paired with a researcher at their institution for a paid internship—an important step toward a career in science. The Health Sciences & Technology Academy “We liken our students to rosebuds. As they grow, you see them blossom into self-confident lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 31, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education SEPA Training Source Type: blogs

In time, we discover ourselves
I was discussing, with my photographer friend, Andy, the endless and inevitably futile task of chasing likes and shares for one’s creative output online. He’s a relative newbie to social media and this quest for some kind of validation having only taken up photography and joined social media several years ago. Me? I’ve probably wasted decades chasing something that doesn’t exist, posting endless photos to some, but ultimately insufficient acclaim, sharing songs and instrumentals on all kinds of platforms and reaping scant reward in terms of listens and that zero-probability chance of being discovere...
Source: David Bradley Sciencebase - Songs, Snaps, Science - January 31, 2024 Category: Science Authors: David Bradley Tags: Mental Health Social Media Writing Source Type: blogs