TWiV 228: Cal Bears go viral
On episode #228 of the science show This Week in Virology, Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi’s sarcoma associated herpesvirus and dengue virus. You can find TWiV #228 at (Source: virology blog)
Source: virology blog - April 14, 2013 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Britt Glaunsinger Dengue Eva Harris hemorrhagic fever HHV-8 kaposi's sarcoma associated herpesvirus kshv mRNA degradation shock syndrome SOX viral Xrn1 Source Type: blogs

Patients Should Always Receive Their Genomic Information According to Recent Report
I have always been enthusiastic about the need to provide patients and healthcare consumers with most, if not all, of their lab test results shortly after they become available. The only exceptions would be results relating to newly diagnosed serious diseases such as cancer where the information should be first communicated in person by a physician. In such cases, there should be a time delay baked into the release of the information to patients. Genomic testing has prompted a new debate about the availability of test results. The wide availability of patient portals/personal health records (PHRs) has also fueled th...
Source: Lab Soft News - April 8, 2013 Category: Pathologists Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Direct Access Testing (DAT) Electronic Medical Record Healthcare Information Technology Lab Information Products Lab Processes and Procedures Lab Regulation Laboratory Industry Trends Medic Source Type: blogs

Breast Cancer
Pathophysiology of Breast Cancer Breast cancer is a: 1) neoplastic transformation of glandular epithelium of the terminal duct unit, lactiferous proximal ducts, or lobules of the breast 2) almost always adenocarcinoma 3) classification is controversial, but most experts recognize in situ (malignant cells do not invade through the basement membrane) and invasive forms 4) in situ types – intraductal (comedo and noncomedo sutypes) in situ, lobular in situ, and papillary in situ 5) invasive types – ductal, lobular, tubular, colloid, and medullary Signs and Symptoms 1) palpable mass – hard, irregular, no discr...
Source: Inside Surgery - March 21, 2013 Category: Surgeons Authors: Editor Tags: Breast Surgery Oncology adenocarcinoma BRCA1 BRCA2 comedo in situ invasive ductal Li Fraumeni lobular peau d'orange Source Type: blogs

The Power of Social Media
In the past, I've discussed the financial challenges facing those of us who conduct research on rare diseases and the important role private foundations play in facilitating our work.  What I haven't mentioned before is the role social media can play in linking researchers with foundations. As some of you may know, I'm on Twitter.  Well... sort of.  I've been on Twitter recently about as much as I've been posting on my blog. But through Twitter, I found the Rally Foundation.  Honestly, I'm not sure I would have found them otherwise.  I'm sure glad I did, though.  They're a fabulous organizat...
Source: Doctor David's Blog - March 14, 2013 Category: Oncologists Tags: Being a Pediatric Oncologist Philanthropy Announcements Source Type: blogs

Cancer Doesn’t Discriminate – another UK guest post
It’s raining outside and a big killer snowstorm is on its way from Kansas.  I opened my email this morning to find another interesting blog from the UK.  This one is from an osteosarcoma survivor named Becky McGuiness.  Like the … Continue reading → (Source: Being Cancer Network)
Source: Being Cancer Network - February 26, 2013 Category: Cancer Authors: Dennis Pyritz Tags: Guest Post * Living with Cancer Anxiety Sarcoma Source Type: blogs

Chris Christie: Very Sensitive
Former White House physician Connie Mariano M.D. set off a firestorm recently by stating the patently obvious fact that New Jersey governor Christ Christie ought to address his morbid obesity prior to entertaining thoughts of running for the Presidency in 2016.  “It’s almost like a time bomb waiting to happen unless he addresses those issues before he runs for office,” Mariano told CNN, saying she's concerned Christie could suffer a heart attack or stroke.   The short-fused Christie unloaded on the good doctor in typically fiery fashion: “People who have a medical license, who have the privil...
Source: Buckeye Surgeon - February 17, 2013 Category: Surgeons Authors: Jeffrey Parks MD Source Type: blogs

Making Friends (sarcoma) – guest post
This is from a dual-purpose blog  The Mind-Body Walk: stepping into the spirit – My Cancer Chronicles .  Cinday Bellinger lives in northern New Mexico.  She is an avid walker with a spiritual outlook.  The physicality of her avocation provides an … Continue reading → (Source: Being Cancer Network)
Source: Being Cancer Network - February 11, 2013 Category: Cancer Authors: Dennis Pyritz Tags: Guest Post * Living with Cancer Sarcoma Symptoms Source Type: blogs

Sarcoma – Signs, Histology, and Treatment
Pathophysiology of Soft Tissue Sarcoma 1) sarcomas of the soft tissue are a family of neoplasms affecting the soft tissue of the body Causes 2) previous radiation 3) HIV 4) genetic predisposition such as L-Fraumeni syndrome 5) asbestosis 6) congenital immunodeficiences 7) dioxin exposure 8) Herpes virus Signs and Symptoms 1) most common presentation is an enlarging mass 2) pain 3) neuralgia and neurologic deficits, if the tumor encases a nerve structure 4) metastases are usually via the blood system and most commonly go to the lungs Characteristic Test Findings Radiology – mass on MRI Histology/Gross Pathology 1) m...
Source: Inside Surgery - January 27, 2013 Category: Surgeons Authors: Editor Tags: Oncology angiosarcoma leimyosarcoma malignant fibrous histiocytosis p53 Schwannoma tumor suppressor Source Type: blogs

USMLE Questions – Characteristic Disease Findings
The United States Medical Licensing Examination (USMLE) is designed to emphasize knowledge of clinical scenarios and clinical pearls, even on Step I. Listed below are some commonly encountered disease findings and characteristics. Feature Disease 45, X chromosome Turner’s syndrome 5-HIAA increased in urine Carcinoid syndrome Aganglionic rectum Hirschsrpung’s disease Apple-core sign on barium enema Colon cancer Arched back (opisthotonos) Tetanus Argyll-Robertson pupil Syphilis Ash leaf on forehead Tuberous sclerosis Auer rods  Acute myelogenous leukemia Austin Flint murmur Aortic regurgitation...
Source: Inside Surgery - January 18, 2013 Category: Surgeons Authors: Editor Tags: Surgpedia USMLE diseases findings VMA water hammer pulse Source Type: blogs

Annual Report to the Nation on Cancer Trends: Cancer Deaths Continue to Fall, But We Can Do Better
This report comes out every year. It is a summation of what we know about the trends in incidence rates for the most common cancers in the United States among both men and women as well as the trends in death rates from those cancers that lead to the highest mortality in the general population as well as specific ethnic groups. It is in a real sense a report card on our progress, which in large part is good but in a number of cancers, not so good. The good news is what we have come to expect: since the year 2000, the overall cancer death rates have continued to decline 1.8% per year in men, 1.4% in women and 0.6% per year ...
Source: Dr. Len's Cancer Blog - January 7, 2013 Category: Cancer Authors: Dr. Len Tags: Access to care Breast Cancer Cancer Care Cervical Cancer Colon Cancer Early detection Lung Cancer Other cancers Prevention Prostate Cancer Rectal Cancer Research Screening Tobacco Treatment Vaccines Source Type: blogs

TWiV 214: This is your brain on polyomavirus
On episode #214 of the science show This Week in Virology, Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons. You can find TWiV #214 at (Source: virology blog)
Source: virology blog - January 7, 2013 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus chemokine coagulation factor cytokine factor X gene therapy innate immunity malignant peripheral nerve sheath tumor polyomavirus sarcoma TLR4 viral Source Type: blogs

Minimal Reporting Guidelines for the Treatment of Cancer Patients
Minimal Reporting Guidelines for the Treatment of Cancer Patients As laboratory physicians, our contribution to patient care is knowledge:  this is the starting point from which all informed therapeutic intervention proceeds.  How that knowledge is obtained and communicated is the art and science of our profession.  These minimal diagnostic guidelines are designed to be used as an aid, not a constraint, in that process.  The guidelines are presented in a specific format out of necessity, but any format that effectively communicates the necessary information in a given patho...
Source: Oncopathology - September 5, 2011 Category: Cancer & Oncology Source Type: blogs