More sexual partners, more cancer?
Two headlines caught my eye recently: The relationship between chronic diseases and number of sexual partners: an exploratory analysis and Study warns more sex might mean higher likelihood for cancer It may be hard to believe, but both of these refer to same medical research. I’m not sure which one I like better. The first one is the actual title of the research, which provides no information about its findings. The second one is a newspaper headline. It cuts right to the chase about the study’s main findings. While it’s much more specific — and alarming — it is also misleading. Is there a link between the number...
Source: Harvard Health Blog - April 28, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Cancer Relationships Sex Sexual Conditions Source Type: blogs

TWiV 579: Reno viral
Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Click arrow to play Download TWiV 579 (61 MB .mp3, 101 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - December 22, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology arbovirus diagnostic assay herpesvirus Kaposi's sarcoma virus mosquito PAN RNA small RNA viral viruses Source Type: blogs

Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD Keynote speech on the JAVELIN not going far enough to improve survival The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs

Abdominal wall mass –MRI Approach
50 yr old lady presents for CEMRI with abdominal wall mass in USG with no history of trauma / fever / surgery.CEMRI shows – Large intense& heterogeneously enhancing altered signal intensity space occupying lesion involving left anterior parietes of abdominal wall extending from supraumbilical to pelvic region with areas of necrosis/ restricted diffusion /predominantly edematous signal components /rectus abdominis not separately identified / properitoneal fat stranding with no intraperitoneal extension / across midline /no definite skin ulceration /regional lymphadenopathy / air /MR demonstrable calcification / f...
Source: Sumer's Radiology Site - February 24, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs

First Ever Medical Humanities Chat (#MedHumChat)
Hey#medtwitter, I'm toying with the idea of starting a narrative medicine twitter chat. each week we discuss a poem, essay, short story (something very brief!) relevant to medicine and our experience. Would folks be interested? Would you participate? Does this already exist?— Colleen Farrell, MD (@colleenmfarrell)December 16, 2018by Christian Sinclair (@ctsinclair)What started off as a spontaneous tweet by resident Colleen Farrell, MD (@colleenmfarrell) generated a swell of interest from the health care Twitter community and now is being fully realized with the first Medical Humanities chat on Twitter (#MedHumCha...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 2, 2019 Category: Palliative Care Tags: arts humanities sinclair tweetchat twitter Source Type: blogs

A Wee Wiggle in my Journey to Family
You're reading A Wee Wiggle in my Journey to Family, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Many of us have faced depression, struggled with low self-esteem, and other debilitating mental health challenges. My own journey with depression was a result of growing up with a rare blood disorder and being told I could never have children of my own. This completely changed my dreams of what family and life meant. Years later I suffered with a rare soft tissue sarcoma, yet, baffling the best of doctors, I survived. I’...
Source: PickTheBrain | Motivation and Self Improvement - December 13, 2018 Category: Consumer Health News Authors: donnagrantwilcox Tags: depression featured psychology self improvement best books Donna Grant Wilcox faith family mental health pickthebrain Source Type: blogs

TWiV 518: Hershey ’ s viruses
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick Buchkovich and Leslie Parent about their careers and their work on human cytomegalovirus and retroviruses. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to play Download TWiV 518 (53 MB .mp3, 86 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become […] (Source: virology blog)
Source: virology blog - November 4, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ESCRT pathway exosome Gag protein genome packaging HCMV HIV-1 human cytomegalovirus late domain nuclear experience retrovirus rous sarcoma virus viral viruses Source Type: blogs

Does free medical school decrease social justice?
BY ANISH KOKA MD The hottest medical school in the country right now is the New York University School of Medicine thanks to the gift of a generous benefactor that promises to make medical school free for all current and future medical students.  The news was met by elation from the medical community of physicians that groans frequently about student debt loads routinely north of $200,000 upon matriculation.  Not surprisingly, the technocrat class of public health experts and economists did not share in the jubilation.  The smarter-than-the-rest-of-us empiricists are, after all, trained to think in terms of social justi...
Source: The Health Care Blog - September 9, 2018 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized @anish_koka Source Type: blogs

Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs

New Nanopackaging for Chemo Agents for Targeted Killing of Tumors
We report for the first time on a nano-drug delivery system based on glucosylated polymeric nanomicelles to actively target the second-generation tyrosine kinase inhibitor dasatinib to glucose-avid pediatric sarcomas by the intravenous route. After a comprehensive physicochemical characterization that confirmed the substantially lower critical micellar concentration and the higher encapsulation capacity of the glucosylated amphiphilic nanocarrier with respect to the pristine counterpart, we showed a 9-fold decrease of the half maximal inhibitory concentration of dasatinib in a rhabdomyosarcoma cell line, Rh30, i...
Source: Medgadget - June 4, 2018 Category: Medical Devices Authors: Editors Tags: Nanomedicine Oncology Source Type: blogs

Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Commentary on Senolytic Gene Therapies to Target p16 Overexpression
This short commentary discusses the utility of Oisin Biotechnologies' initial strategy for destroying senescent cells, which is to use p16 expression as the determining sign of senescence. Oisin's implementation involves delivering dormant DNA machinery indiscriminately to all cells, and then triggering it only in cells with high levels of p16. This particular implementation is one of many possibilities in the gene therapy space, and thus various other groups are working on their own p16-based approaches as senolytic development as a treatment for aging grows in funding and popularity. It isn't just senescence and a...
Source: Fight Aging! - May 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Mice don ’ t vomit
The fact that mice don’t vomit is one of the many things that I learned while reading an extraordinary May 16 Boston Globe article about an experimental cancer treatment that cured, yes, cured a dog, a golden retriever, from soft tissue sarcoma. This cancer treatment, immunotherapy, might possibly (someday) help human patients, too. Anyway, have a look here: goo.gl/DyBnJZ Really quite amazing. Incidentally, many thanks to Cynthia for posting the link to this article on Facebook… Quick update: our 8.5 month old kittens, Pandora and Pixie, were sterilized on Monday and are doing well, phew… Tomorrow I̵...
Source: Margaret's Corner - May 23, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll golden retriever immunotherapy sarcoma Source Type: blogs

Eponymythology: Atraumatic Abdominal Ecchymosis
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Overview We review the original descriptions of 5 eponymous signs (n=6) associated with non-traumatic abdominal ecchymosis. These commonly cited eponyms involving the abdominal wall and flanks (Grey Turner, Cullen and Stabler); scrotum (Bryant) and upper thigh (Fox) may be useful clues directing the examiner to consider potentially serious causes of abdominal pathology. Cullen sign Thomas Stephen Cullen (1869–1953) was a Canadian gynecologist Non-traumatic peri-um...
Source: Life in the Fast Lane - April 18, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Eponymythology Abdominal Ecchymosis Bryant sign Cullen sign fox sign Francis Edward Stabler George Grey Turner Grey Turner sign John Adrian Fox John Henry Bryant Stabler sign Thomas Stephen Cullen Source Type: blogs

Senolytic Drugs Fail to Kill Cancerous Cells with Senescent Gene Expression Signatures, but a Gene Therapy Succeeds
Some cancerous cells express signatures normally associated with senescent cells, so why not try senolytic compounds against them? This is something of a full circle, given that most of the current senolytic drug candidates were originally characterized and tested as potential chemotherapeutics. The open access paper here is interesting for two points: firstly, that senolytic drugs didn't kill cancerous cells with a senescent signature, and secondly that a suicide gene therapy targeting that signature does work against both normal senescent cells and cancerous cells with a senescent signature. The gene therapy approach rep...
Source: Fight Aging! - March 7, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs