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Infectious Disease: Hepatitis
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Discontinuation of Nucleos(t)ide Analog treatment in HBeAg-Negative Non-Cirrhotic Chronic Hepatitis B Patients: Real-Life Data of 20 Years
CONCLUSION: In resource-limited areas where follow-up of HBsAg or other markers is not possible, nucleos(t)ide analog discontinuation can be considered in patients in the early stage, with low baseline hepatitis B virus DNA and ALT levels, after a long consolidation therapy.PMID:37681268 | DOI:10.5152/tjg.2023.22823
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Bilg ül Mete Sibel Y ıldız Kaya Abdurrahman Kaya Ahmet Furkan Kurt Osman Faruk Bayramlar R ıdvan Karaali İlker İnanç Balkan M ücahit Yemişen Re şat Özaras Ne şe Saltoğlu Fehmi Tabak Source Type: research
A novel hepatitis B virus capsid assembly modulator QL-007 inhibits HBV replication and infection through altering capsid assembly
In conclusion, our findings underscore the potential of QL-007 as an effective agent against HBV replication and introduce it as a novel CpAM for the antiviral treatment of chronic hepatitis B.PMID:37683938 | DOI:10.1016/j.antiviral.2023.105715
Source: Antiviral Research - September 8, 2023 Category: Virology Authors: Jingyuan Xi Zhiqiang Gu Chunyan Sun Zimin Chen Ting Zhang Ran Chen Tianyu Liu Hao Liao Jun Zou Danli Yang Qiang Xu Jie Wang Guochao Wei Zhe Cheng Fengmin Lu Xiangmei Chen Source Type: research
Risk of Hepatitis B Virus Reactivation in Patients with Resolved Infection on Therapy with Corticosteroids and Conventional Synthesis Immunosuppressants for Kidney Disease: A Single-Center Analysis of 258 Patients
CONCLUSIONS: Among patients with a previously resolved hepatitis B virus infection on therapy with corticosteroids and conventional synthesis immunosuppressants for kidney disease, hepatitis B virus reactivation was not common and severe, suggesting that universal prophylaxis may not be justified or cost-effective in this clinical setting.PMID:37681265 | DOI:10.5152/tjg.2023.22511
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Pingyang Han Ziqiu Wang Zhaohui Wang Source Type: research
Mechanism of Simiao Decoction in the treatment of atherosclerosis based on network pharmacology prediction and molecular docking
This study aims to initially clarify the potential mechanism of SMD in the treatment of AS based on network pharmacology and molecular docking techniques. The principal components and corresponding protein targets of SMD were searched on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and the compound-target network was constructed by Cytoscape3.9.1. AS targets were searched on DrugBank, OMIM, and TTD databases. The intersection of compound target and disease target was obtained and the coincidence target was imported into STRING database to construct a protein-protein interaction network. ...
Source: Atherosclerosis - September 8, 2023 Category: Cardiology Authors: Qian Li Yihui Chai Wen Li Liancheng Guan Yizi Fan Yunzhi Chen Source Type: research
Discontinuation of Nucleos(t)ide Analog treatment in HBeAg-Negative Non-Cirrhotic Chronic Hepatitis B Patients: Real-Life Data of 20 Years
CONCLUSION: In resource-limited areas where follow-up of HBsAg or other markers is not possible, nucleos(t)ide analog discontinuation can be considered in patients in the early stage, with low baseline hepatitis B virus DNA and ALT levels, after a long consolidation therapy.PMID:37681268 | DOI:10.5152/tjg.2023.22823
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Bilg ül Mete Sibel Y ıldız Kaya Abdurrahman Kaya Ahmet Furkan Kurt Osman Faruk Bayramlar R ıdvan Karaali İlker İnanç Balkan M ücahit Yemişen Re şat Özaras Ne şe Saltoğlu Fehmi Tabak Source Type: research
Risk of Hepatitis B Virus Reactivation in Patients with Resolved Infection on Therapy with Corticosteroids and Conventional Synthesis Immunosuppressants for Kidney Disease: A Single-Center Analysis of 258 Patients
CONCLUSIONS: Among patients with a previously resolved hepatitis B virus infection on therapy with corticosteroids and conventional synthesis immunosuppressants for kidney disease, hepatitis B virus reactivation was not common and severe, suggesting that universal prophylaxis may not be justified or cost-effective in this clinical setting.PMID:37681265 | DOI:10.5152/tjg.2023.22511
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Pingyang Han Ziqiu Wang Zhaohui Wang Source Type: research
A novel hepatitis B virus capsid assembly modulator QL-007 inhibits HBV replication and infection through altering capsid assembly
In conclusion, our findings underscore the potential of QL-007 as an effective agent against HBV replication and introduce it as a novel CpAM for the antiviral treatment of chronic hepatitis B.PMID:37683938 | DOI:10.1016/j.antiviral.2023.105715
Source: Antiviral Research - September 8, 2023 Category: Virology Authors: Jingyuan Xi Zhiqiang Gu Chunyan Sun Zimin Chen Ting Zhang Ran Chen Tianyu Liu Hao Liao Jun Zou Danli Yang Qiang Xu Jie Wang Guochao Wei Zhe Cheng Fengmin Lu Xiangmei Chen Source Type: research
Discontinuation of Nucleos(t)ide Analog treatment in HBeAg-Negative Non-Cirrhotic Chronic Hepatitis B Patients: Real-Life Data of 20 Years
CONCLUSION: In resource-limited areas where follow-up of HBsAg or other markers is not possible, nucleos(t)ide analog discontinuation can be considered in patients in the early stage, with low baseline hepatitis B virus DNA and ALT levels, after a long consolidation therapy.PMID:37681268 | DOI:10.5152/tjg.2023.22823
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Bilg ül Mete Sibel Y ıldız Kaya Abdurrahman Kaya Ahmet Furkan Kurt Osman Faruk Bayramlar R ıdvan Karaali İlker İnanç Balkan M ücahit Yemişen Re şat Özaras Ne şe Saltoğlu Fehmi Tabak Source Type: research
Risk of Hepatitis B Virus Reactivation in Patients with Resolved Infection on Therapy with Corticosteroids and Conventional Synthesis Immunosuppressants for Kidney Disease: A Single-Center Analysis of 258 Patients
CONCLUSIONS: Among patients with a previously resolved hepatitis B virus infection on therapy with corticosteroids and conventional synthesis immunosuppressants for kidney disease, hepatitis B virus reactivation was not common and severe, suggesting that universal prophylaxis may not be justified or cost-effective in this clinical setting.PMID:37681265 | DOI:10.5152/tjg.2023.22511
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Pingyang Han Ziqiu Wang Zhaohui Wang Source Type: research
Atypical Varicella-Zoster Virus Reactivation: A Case Report
Eur J Case Rep Intern Med. 2023 Aug 11;10(9):003945. doi: 10.12890/2023_003945. eCollection 2023.ABSTRACTVaricella-zoster virus (VZV) commonly causes benign skin manifestations in children; it then establishes a latent infection and may reactivate, causing herpes zoster. The most common zoster complication is postherpetic neuralgia, but complications can also occur without a rash. VZV infection may cause neurological manifestations and even vasculopathy may occur, in both primary and reactivated VZV infection. Thrombotic complications are mainly described in children, while a few case reports have described cerebral venous...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Francesca Salvotti Simone Trapletti Giulia Chiarini Maurizio Castellano Maria Lorenza Muiesan Source Type: research
A novel hepatitis B virus capsid assembly modulator QL-007 inhibits HBV replication and infection through altering capsid assembly
In conclusion, our findings underscore the potential of QL-007 as an effective agent against HBV replication and introduce it as a novel CpAM for the antiviral treatment of chronic hepatitis B.PMID:37683938 | DOI:10.1016/j.antiviral.2023.105715
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Jingyuan Xi Zhiqiang Gu Chunyan Sun Zimin Chen Ting Zhang Ran Chen Tianyu Liu Hao Liao Jun Zou Danli Yang Qiang Xu Jie Wang Guochao Wei Zhe Cheng Fengmin Lu Xiangmei Chen Source Type: research
Atypical Varicella-Zoster Virus Reactivation: A Case Report
Eur J Case Rep Intern Med. 2023 Aug 11;10(9):003945. doi: 10.12890/2023_003945. eCollection 2023.ABSTRACTVaricella-zoster virus (VZV) commonly causes benign skin manifestations in children; it then establishes a latent infection and may reactivate, causing herpes zoster. The most common zoster complication is postherpetic neuralgia, but complications can also occur without a rash. VZV infection may cause neurological manifestations and even vasculopathy may occur, in both primary and reactivated VZV infection. Thrombotic complications are mainly described in children, while a few case reports have described cerebral venous...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Francesca Salvotti Simone Trapletti Giulia Chiarini Maurizio Castellano Maria Lorenza Muiesan Source Type: research
Discontinuation of Nucleos(t)ide Analog treatment in HBeAg-Negative Non-Cirrhotic Chronic Hepatitis B Patients: Real-Life Data of 20 Years
CONCLUSION: In resource-limited areas where follow-up of HBsAg or other markers is not possible, nucleos(t)ide analog discontinuation can be considered in patients in the early stage, with low baseline hepatitis B virus DNA and ALT levels, after a long consolidation therapy.PMID:37681268 | DOI:10.5152/tjg.2023.22823
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Bilg ül Mete Sibel Y ıldız Kaya Abdurrahman Kaya Ahmet Furkan Kurt Osman Faruk Bayramlar R ıdvan Karaali İlker İnanç Balkan M ücahit Yemişen Re şat Özaras Ne şe Saltoğlu Fehmi Tabak Source Type: research
Risk of Hepatitis B Virus Reactivation in Patients with Resolved Infection on Therapy with Corticosteroids and Conventional Synthesis Immunosuppressants for Kidney Disease: A Single-Center Analysis of 258 Patients
CONCLUSIONS: Among patients with a previously resolved hepatitis B virus infection on therapy with corticosteroids and conventional synthesis immunosuppressants for kidney disease, hepatitis B virus reactivation was not common and severe, suggesting that universal prophylaxis may not be justified or cost-effective in this clinical setting.PMID:37681265 | DOI:10.5152/tjg.2023.22511
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Pingyang Han Ziqiu Wang Zhaohui Wang Source Type: research
Mechanism of Simiao Decoction in the treatment of atherosclerosis based on network pharmacology prediction and molecular docking
This study aims to initially clarify the potential mechanism of SMD in the treatment of AS based on network pharmacology and molecular docking techniques. The principal components and corresponding protein targets of SMD were searched on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and the compound-target network was constructed by Cytoscape3.9.1. AS targets were searched on DrugBank, OMIM, and TTD databases. The intersection of compound target and disease target was obtained and the coincidence target was imported into STRING database to construct a protein-protein interaction network. ...
Source: Atherosclerosis - September 8, 2023 Category: Cardiology Authors: Qian Li Yihui Chai Wen Li Liancheng Guan Yizi Fan Yunzhi Chen Source Type: research
