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Cancer: Carcinoma
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Differentiating Keratoacanthoma From Squamous Cell Carcinoma: Are We Losing the Battle or Our Bearings? - Comment on "Intralesional Methotrexate for Keratoacanthomas: A Case Series"
Actas Dermosifiliogr. 2023 Sep 14:S0001-7310(23)00734-2. doi: 10.1016/j.ad.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37716500 | DOI:10.1016/j.ad.2023.08.010
Source: Actas Dermo-Sifiliograficas - September 16, 2023 Category: Dermatology Authors: P L ópez Sanz Miriam Fern ández-Parrado Eduardo Escario Travesedo Source Type: research
Primary melanoma of female urethra: A case diagnosed in Ouagadougou
We report a case of primary melanoma of a female urethra diagnosed at a non-metastatic stage in a 48-year-old patient with a history of breast carcinoma treated with radiotherapy and hormone therapy. The patient was consulting for dysuria, hematuria, and perineal pain. The clinical examination found a prolapsed and black mass, developed at the expense of the urethra and located at the anterosuperior part of the vulva. The mass biopsy revealed a proliferation of fusiform and globular cells loaded with black pigment expressing the anti-HMB 45 and PS 100 antibodies. The extension assessment showed an absence of secondary loca...
Source: Annales de Pathologie - September 16, 2023 Category: Pathology Authors: Aim é Sosthène Ouedraogo Franck Auguste Hermann Ad émayali Ido Ibrahim Savadogo Souleymane Ouattara Rakiswend é Alexis Ouedraogo A ïda Sandrine Ouedraogo Assita Sanou-Lamien Olga M Lompo Source Type: research
Correction to: ORCHID: A phase II study of Olaparib in Metastatic Renal Cell Carcinoma Patients HarborIng a BAP1 or Other DNA Repair Gene Mutations
Oncologist. 2023 Sep 16:oyad265. doi: 10.1093/oncolo/oyad265. Online ahead of print.NO ABSTRACTPMID:37715956 | DOI:10.1093/oncolo/oyad265
Source: The Oncologist - September 16, 2023 Category: Cancer & Oncology Source Type: research
Salmonella inhibits tumor metastasis by downregulating epithelial cell adhesion molecules through the protein kinase-B/mammalian target of rapamycin signaling pathway
Int J Biol Macromol. 2023 Sep 14:126913. doi: 10.1016/j.ijbiomac.2023.126913. Online ahead of print.ABSTRACTEpithelial cell adhesion molecules (EpCAM) are highly expressed in many carcinomas and regulate the epithelial-mesenchymal transition, which is required for tumor metastasis. Furthermore, EpCAM overexpression induces tumor cells to develop a stem cell-like phenotype and promotes tumor progression. Targeting EpCAM may be a promising approach for inhibiting tumor metastasis and progression. Salmonella treatment suppresses tumor growth and reduces metastatic nodules in tumor-bearing mice. Based on these results, we hypo...
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: Wei-Che Yen Qiao-Zhu Li Li-Hsien Wu Wei-Ya Lee Wen-Wei Chang Peng-Ju Chien Che-Hsin Lee Source Type: research
Acquired angioedema due to C1-inhibitor-deficiency (AAE-C1-INH) - a bi-center retrospective study on diagnosis, course and therapy
CONCLUSION: AAE-C1-INH is characterized by late onset swellings mainly involving the face and low C1-INH levels. Diagnostic delay for AAE-C1-INH is further decreasing despite being about 10-fold rarer than HAE. Patients severely affected without underlying condition or no indication for treatment could benefit from off-label therapy.PMID:37716525 | DOI:10.1016/j.jaip.2023.09.003
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Felix Johnson Janina Hahn Benedikt Hofauer Jens Greve Barbara Wollenberg Thomas K Hoffmann Robin Lochbaum Susanne Trainotti Source Type: research
Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis
Life Sci. 2023 Sep 14:122096. doi: 10.1016/j.lfs.2023.122096. Online ahead of print.ABSTRACTAIMS: Paclitaxel (Pax) is a chemotherapeutic drug from the taxane family that is used in the treatment of human cancer, including ovarian, breast, and non-small cell lung carcinoma. Chrysin (CR) has antioxidant, anti-inflammatory, anti-apoptotic, anti-diabetic, and anti-carcinogenic properties, as well as hepatoprotective and renoprotective activities. In the present study, we evaluated the protective effect of CR against Pax-induced hepatorenal toxicity on inflammation, apoptosis, antioxidant levels, oxidative DNA damage, and histo...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Selim Çomaklı Sel çuk Özdemir Meryem G üloğlu Source Type: research
Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis
Cancer Epidemiol. 2023 Sep 14;86:102451. doi: 10.1016/j.canep.2023.102451. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is considered a multifactorial disease and has been associated with microbial infections, although the association with Candida spp. is still controversial. This systematic review focused on clinical trials which evaluated the relation between oral Candida spp colonization and OSCC. PubMed; Scopus; Embase; Web of Science and Scientific Direct were assessed. Independent reviewers conducted the diagram steps. For data extraction the PRISMA protocol was followed. The quality analysis of ...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Camilla Olga Tasso T úlio Morandin Ferrisse Anal ú Barros de Oliveira Beatriz Ribeiro Ribas Janaina Habib Jorge Source Type: research
DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells
In conclusion, overexpression of DUSP1 can target and reduce the expression of miR-21, block the JAK2/STAT3 signaling pathway, reduce the viability of CC cells, inhibit the proliferation and migration and invasion ability of CC cells, and induce apoptosis of CC cells, thus providing a theoretical basis for the targeted treatment of clinical CC.PMID:37715430 | DOI:10.14715/cmb/2023.69.8.6
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Hailin Chen Songsen Ren Hui Wan Wengong Wei Yi Luo Meiling Cai Source Type: research
MicroRNAs and their vital role in Apoptosis in Hepatocellular carcinoma: miRNA-based diagnostic and treatment methods
Gene. 2023 Sep 14:147803. doi: 10.1016/j.gene.2023.147803. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most prevalent malignancies with high invasive and metastatic capability. Although significant advances have been made in the treatment of HCC, the overall survival rate of patients is still low. It is essential to explore accurate biomarkers for early diagnosis and prognosis along with therapeutic procedures to increase the survival rate of these patients. Anticancer therapies can contribute to induce apoptosis for the elimination of cancerous cells. However, dysregulated apoptosis and prol...
Source: Gene - September 16, 2023 Category: Genetics & Stem Cells Authors: Masoumeh Hajizadeh Farnaz Hajizadeh Sevil Ghaffarei Mohammad Amin Doustvandi Khadijeh Hajizadeh Seyyed Mohammad Yaghoubi Fateme Mohammadnejad Nadia Allahyarzadeh Khiabani Pegah Mousavi Behzad Baradaran Source Type: research
Transcriptomic Analysis in Renal Cell Carcinoma and COVID-19 patients
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):156-162. doi: 10.14715/cmb/2023.69.8.24.ABSTRACTCOVID-19 pandemic poses a heavy risk upon global public health. The disease's severity and infection rate are high, especially among cancer patients. The current research was conducted to identify the most common biological pathways and how far they are associated with COVID-19 infection and clear cell renal cell carcinoma. In the current study, the authors analyzed the differentially expressed genes from the experimental and control groups with the help of the GEO2R tool. The study analyzed the protein-protein interactions th...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Maha Abdulla Alwaili Source Type: research
Simultaneous quantification of Gadoxetic acid and Cisplatin in hepatocellular carcinomas using laser ablation-inductively coupled plasma-mass spectrometry
Metallomics. 2023 Sep 15:mfad052. doi: 10.1093/mtomcs/mfad052. Online ahead of print.ABSTRACTThe gadolinium-based contrast agent Gadoxetic acid and the platinum-based anti-tumor agent Cisplatin were quantitatively imaged in liver and liver cancer (hepatocellular carcinoma, HCC) tissue of rats by means of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). HCC bearing rats simultaneously received a tail vein injection of the hepatocyte-specific magnetic resonance imaging contrast agent Gadoxetic acid and a transarterial injection of Cisplatin 15 min before sacrifice and liver removal. Resecting HCC with...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Katharina Kronenberg Julia Werner Peter Bohrer Katja Steiger Rebecca Buchholz Maximilian von Bremen-K ühne Matthias Elinkmann Philipp M Paprottka Rickmer F Braren Fabian K Loh öfer Uwe Karst Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
Progress in the treatment of drug-loaded nanomaterials in renal cell carcinoma
This article reviews the use of nanomaterials, such as liposomes, polymeric nanoparticles, nanocomposites, carbon nanomaterials, nanobubbles, nanomicelles, and mesoporous silica nanoparticles, for RCC treatment, and discusses their advantages and disadvantages.PMID:37716114 | DOI:10.1016/j.biopha.2023.115444
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Jianyang Li Kunzhe Wu Jinmei Zhang Huan Gao Xiaohua Xu Source Type: research
Retroperitoneal laparoscopic partial nephrectomy for cystic renal cell carcinoma: A video vignette
Asian J Surg. 2023 Sep 14:S1015-9584(23)01410-0. doi: 10.1016/j.asjsur.2023.09.009. Online ahead of print.NO ABSTRACTPMID:37716884 | DOI:10.1016/j.asjsur.2023.09.009
Source: Asian Journal of Surgery - September 16, 2023 Category: Surgery Authors: Baonan Dong Hui Zhan Ting Luan Jiansong Wang Source Type: research
Aflatoxin B1 triggers apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway
Ecotoxicol Environ Saf. 2023 Sep 14;264:115478. doi: 10.1016/j.ecoenv.2023.115478. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is considered the most toxic carcinogenic compound, and exposure to AFB1 is highly associated with hepatocellular carcinoma. The aim of this study was to investigate the effects of different doses of AFB1 on growth performance and the liver of rabbits, as well as explore its underlying mechanisms. A total of eighty 30-day-old meat rabbits were randomly divided into four treatments. The control group was fed a pollution-free diet, while the AFL, AFM, and AFH groups were fed contaminated diets ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Lu Zhang Shaowen Shi Ying Liu Yuqing Cui Yixuan Zhu Yongzhan Bao Baojiang Chen Wanyu Shi Source Type: research
