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Total 97099 results found since Jan 2013.
TMEM64 is highly expressed in hepatocellular carcinoma and promotes tumor cell proliferation and invasion
CONCLUSION: A high TMEM64 expression may serve as an independent risk factor for poor prognosis of HCC and promotes proliferation, migration, and invasion of HCC cells in vitro.PMID:37712271 | PMC:PMC10505578 | DOI:10.12122/j.issn.1673-4254.2023.08.11
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: D Cao J Cai Y Li R Dong Z Wang X Zuo Source Type: research
Dealcoholized red wine inhibits occurrence and progression of hepatocellular carcinoma possibly by inducing cell cycle arrest and apoptosis
CONCLUSION: DRW inhibits the occurrence and progression of HCC, and this effect is mediated possibly by inducing cell cycle arrest and apoptosis.PMID:37712265 | PMC:PMC10505577 | DOI:10.12122/j.issn.1673-4254.2023.08.05
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Y Lan K Wang Z Lan H Zhou J Sun Source Type: research
Clinical experiences with online adaptive radiotherapy of vulvar carcinoma
CONCLUSION: CTVs and PTVs dose coverage were significantly improved with adaptation compared to image-guided RT. This gain was robust during the treatment time.PMID:37713179 | DOI:10.1080/0284186X.2023.2257377
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Malene E Bak Nikolaj K G Jensen Trine J N øttrup Hanne F Mathiesen Henrik Roed Maria Sj ölin Flemming Kj ær-Kristoffersen Vibeke N Hansen Ivan R Vogelius Source Type: research
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
Arch Toxicol. 2023 Sep 15. doi: 10.1007/s00204-023-03600-6. Online ahead of print.ABSTRACTOccupational and environmental exposure of various toxins or cigarette smoke causes non-small cell lung carcinoma (NSCLC); a devastating disease with a very low survival rate after metastasis. Increased activity of plasmin is a hallmark in NSCLC metastasis. It is accepted that metastatic cells exhibit higher plasmin activity than cells from primary tumors. Mechanisms behind this elevation, however, are barely understood. We compared plasmin activity and cell migration of A549 cells derived from a primary lung tumor with metastatic H12...
Source: Archives of Toxicology - September 15, 2023 Category: Toxicology Authors: Sarah Zeitlmayr Ditila Cami Belinda Selmani Thomas Gudermann Andreas Breit Source Type: research
Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities
Rev Endocr Metab Disord. 2023 Sep 16. doi: 10.1007/s11154-023-09836-y. Online ahead of print.ABSTRACTDue to its rarity and non-specific clinical presentation, accurate diagnosis, and optimal therapeutic strategy of medullary thyroid carcinoma (MTC) remain challenging. Molecular imaging provides valuable tools for early disease detection, monitoring treatment response, and guiding personalized therapies. By enabling the visualization of molecular and cellular processes, these techniques contribute to a deeper understanding of disease mechanisms and the development of more effective clinical interventions. Different nuclear ...
Source: ENDOCR REV - September 15, 2023 Category: Endocrinology Authors: Alessio Imperiale Valentina Berti Micka ël Burgy Roberto Luigi Cazzato Arnoldo Piccardo Giorgio Treglia Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
TMEM64 is highly expressed in hepatocellular carcinoma and promotes tumor cell proliferation and invasion
CONCLUSION: A high TMEM64 expression may serve as an independent risk factor for poor prognosis of HCC and promotes proliferation, migration, and invasion of HCC cells in vitro.PMID:37712271 | PMC:PMC10505578 | DOI:10.12122/j.issn.1673-4254.2023.08.11
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: D Cao J Cai Y Li R Dong Z Wang X Zuo Source Type: research
Dealcoholized red wine inhibits occurrence and progression of hepatocellular carcinoma possibly by inducing cell cycle arrest and apoptosis
CONCLUSION: DRW inhibits the occurrence and progression of HCC, and this effect is mediated possibly by inducing cell cycle arrest and apoptosis.PMID:37712265 | PMC:PMC10505577 | DOI:10.12122/j.issn.1673-4254.2023.08.05
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Y Lan K Wang Z Lan H Zhou J Sun Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature
CONCLUSIONS: Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.PMID:37714729 | DOI:10.1016/j.riam.2023.05.001
Source: Revista Iberoamericana de Micologia - September 15, 2023 Category: Biology Authors: Muhammed Cihan I şık O ğuz Karcıoğlu G ülşen Hazırolan Dolunay G ülmez Mehmet Ruhi Onur Mehmet Mahir Kunt Sevtap Arikan-Akdagli G ökhan Metan Source Type: research
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
Arch Toxicol. 2023 Sep 15. doi: 10.1007/s00204-023-03600-6. Online ahead of print.ABSTRACTOccupational and environmental exposure of various toxins or cigarette smoke causes non-small cell lung carcinoma (NSCLC); a devastating disease with a very low survival rate after metastasis. Increased activity of plasmin is a hallmark in NSCLC metastasis. It is accepted that metastatic cells exhibit higher plasmin activity than cells from primary tumors. Mechanisms behind this elevation, however, are barely understood. We compared plasmin activity and cell migration of A549 cells derived from a primary lung tumor with metastatic H12...
Source: Archives of Toxicology - September 15, 2023 Category: Toxicology Authors: Sarah Zeitlmayr Ditila Cami Belinda Selmani Thomas Gudermann Andreas Breit Source Type: research
Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities
Rev Endocr Metab Disord. 2023 Sep 16. doi: 10.1007/s11154-023-09836-y. Online ahead of print.ABSTRACTDue to its rarity and non-specific clinical presentation, accurate diagnosis, and optimal therapeutic strategy of medullary thyroid carcinoma (MTC) remain challenging. Molecular imaging provides valuable tools for early disease detection, monitoring treatment response, and guiding personalized therapies. By enabling the visualization of molecular and cellular processes, these techniques contribute to a deeper understanding of disease mechanisms and the development of more effective clinical interventions. Different nuclear ...
Source: ENDOCR REV - September 15, 2023 Category: Endocrinology Authors: Alessio Imperiale Valentina Berti Micka ël Burgy Roberto Luigi Cazzato Arnoldo Piccardo Giorgio Treglia Source Type: research
Metaplastic Breast Carcinoma: Clinicopathologic Features and Recurrence Score Results From a Population-based Database
CONCLUSIONS: All molecular subtypes of MBC had a poorer prognosis compared with IDC, NOS. The different molecular subtypes of MBC did not affect the BCSD. HR-positive MBC patients had a significantly higher high-risk RS than IDC, NOS patients.PMID:37705411 | DOI:10.1097/COC.0000000000001041
Source: Clinical Breast Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Valarie McMurtry Allison S Cleary Ana L Ruano Lesley Lomo H Evin Gulbahce Source Type: research
