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A journey through clinic and research
I started to study Medicine at the University of Genoa, Italy more than 20 years ago and I now realize that I was quite far from understanding what ‘Medicine’ really means. After weeks and weeks spent on books during the first year, I understood that becoming a MD not only requires the willingness to help people with health problems, but also strong motivation and dedication to learn a huge amount of notions. In Italy, as it is the case for several other countries, the University courses last 6 years, during which the MD student is fully engaged by individual study, lessons and seminars, exercises, and internships. Wit...
Source: European Heart Journal - March 29, 2021 Category: Cardiology Source Type: research

The Prevalence of Metabolic Syndrome in Ethiopian Population: A Systematic Review and Meta-analysis.
Conclusions: The findings revealed an emerging high prevalence of metabolic syndrome in Ethiopia. Therefore, early intervention is required for the primary prevention of the occurrence of metabolic syndrome and the further reduction of the morbidity and mortality related to it. PMID: 33489358 [PubMed - in process]
Source: Journal of Obesity - January 27, 2021 Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research

Prevalence of cardiometabolic syndrome in HIV-infected persons: a systematic review
ConclusionsCMetS was a common problem among HIV infected persons. Several RFs can contribute to the development of CMetS with smoking and hypertension highly interrelated.PROSPERO-numberCRD42018107187.
Source: Journal of Diabetes and Metabolic Disorders - June 8, 2020 Category: Endocrinology Source Type: research

Cardiovascular disease and use of contemporary protease inhibitors: the D:A:D international prospective multicohort study
Publication date: June 2018Source: The Lancet HIV, Volume 5, Issue 6Author(s): Lene Ryom, Jens D Lundgren, Wafaa El-Sadr, Peter Reiss, Ole Kirk, Matthew Law, Andrew Phillips, Rainer Weber, Eric Fontas, Antonella d' Arminio Monforte, Stéphane De Wit, Francois Dabis, Camilla I Hatleberg, Caroline Sabin, Amanda Mocroft, D:A:D study groupSummaryBackgroundAlthough earlier protease inhibitors have been associated with increased risk of cardiovascular disease, whether this increased risk also applies to more contemporary protease inhibitors is unknown. We aimed to assess whether cumulative use of ritonavir-boosted atazanavir and...
Source: The Lancet HIV - July 10, 2018 Category: Infectious Diseases Source Type: research

Editorial Message and Issue Highlights – Vol. 15, No. 1 –2, January-February 2018
Dear Colleagues: Welcome to the January-February 2018 issue of Innovations in Clinical Neuroscience (ICNS). This is a milestone year for us as it marks the beginning of our 15th year of publication! We are pleased to continue serving you, our valued readers and colleagues, by providing peer-reviewed, evidence-based information on the latest innovations in both research and clinical practice in the field of neuroscience. We’d like to thank those dedicated readers who have been with us since 2004, the year we launched the journal, and to welcome new readers who are just discovering ICNS and what it has to offer. We’d als...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Editor's Message: Issue Highlights Source Type: research

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders. KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy INTRODUCTION Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research

A meta-analysis investigating incidence and features of stroke in HIV-infected patients in the highly active antiretroviral therapy era
Conclusion: Stroke represents a relatively common complication in young, HAART-treated HIV patients. Apart from traditional cardiovascular risk factors, HIV-RNA viral load may help to target and manage patients at risk.
Source: Journal of Cardiovascular Medicine - October 30, 2015 Category: Cardiology Tags: Stroke in HIV Source Type: research

Carotid artery thickness is associated with chronic use of highly active antiretroviral therapy in patients infected with human immunodeficiency virus: A 3.0 Tesla magnetic resonance imaging study
ConclusionsIndividuals with HIV infection on chronic HAART had increased carotid artery wall thickness as compared to similar controls. In subjects with HIV infection, the presence of lipoaccumulation and longer duration of protease inhibitor therapy were associated with greater wall thickness.
Source: HIV Medicine - October 1, 2015 Category: Infectious Diseases Authors: TM LaBounty, WD Hardy, Z Fan, R Yumul, D Li, R Dharmakumar, A Hernandez Conte Tags: Original Research Source Type: research

Stroke in HIV-infected African Americans: a retrospective cohort study
Abstract The risk of having a first stroke is nearly twice as high among African Americans compared to Caucasians. HIV/AIDS is an independent risk factor for stroke. Our study aimed to report the risk factors and short-term clinical outcomes of African Americans with HIV infection and new-onset stroke admitted at the Johns Hopkins Hospitals (2000–2012). Multivariate linear regression was used to examine the association between potential predictors and odds of an unfavorable outcome, defined as a higher modified Rankin Scale (mRS) score on hospital discharge. African Americans comprised 105/125 (84 %) of HIV-inf...
Source: Journal of NeuroVirology - July 9, 2015 Category: Neurology Source Type: research

Time trends for risk of severe age-related diseases in individuals with and without HIV infection in Denmark: a nationwide population-based cohort study
Publication date: Available online 27 May 2015 Source:The Lancet HIV Author(s): Line D Rasmussen , Margaret T May , Gitte Kronborg , Carsten S Larsen , Court Pedersen , Jan Gerstoft , Niels Obel Background Whether the reported high risk of age-related diseases in HIV-infected people is caused by biological ageing or HIV-associated risk factors such as chronic immune activation and low-grade inflammation is unknown. We assessed time trends in age-standardised and relative risks of nine serious age-related diseases in a nationwide cohort study of HIV-infected individuals and population controls. Methods We identified all ...
Source: The Lancet HIV - May 28, 2015 Category: Infectious Diseases Source Type: research