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Specialty: Cardiology
Therapy: Stem Cell Therapy

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Total 65 results found since Jan 2013.

Stem Cell Therapies for Cardiovascular Diseases: What Does the Future Hold?
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality around the globe. In Australia, one in six people are affected by CVD and a total of 4.2 million people are suffering from heart disease, stroke or vascular disease. Coronary artery disease affects around 1.2 million Australians, many of whom develop chronic heart failure as a result of ischaemic cardiomyopathy. The management of CVD has evolved tremendously in the past three decades, but the majority of treatments are not curative.
Source: Heart, Lung and Circulation - January 24, 2017 Category: Cardiology Authors: Hai-Ying Chen, Padraig Michael Strappe, Le-xin Wang Tags: Editorial Source Type: research

CardioBreak: SSRIs and Brain Bleeds; Speeding the Epi Shots; Stem Cell Gamble in Stroke
(MedPage Today) -- Recent developments of interest in cardiovascular medicine
Source: MedPage Today Cardiovascular - December 12, 2016 Category: Cardiology Source Type: news

Persistent stem cell-driven inflammation in patients with prior MI and stroke
<a href="article.aspx?volume=&page=">This editorial refers to ‘Increased haematopoietic activity in patients with atherosclerosis’††, by F.M. van der Valk et al., on page 425.</a>
Source: European Heart Journal - July 27, 2016 Category: Cardiology Source Type: research

Stem Cells May Offer New Hope to Stroke Survivors
Title: Stem Cells May Offer New Hope to Stroke SurvivorsCategory: Health NewsCreated: 6/2/2016 12:00:00 AMLast Editorial Review: 6/3/2016 12:00:00 AM
Source: MedicineNet Heart General - June 3, 2016 Category: Cardiology Source Type: news

Developments in the management of Chagas cardiomyopathy.
Authors: Tanowitz HB, Machado FS, Spray DC, Friedman JM, Weiss OS, Lora JN, Nagajyothi J, Moraes DN, Garg NJ, Nunes MC, Ribeiro AL Abstract Over 100 years have elapsed since the discovery of Chagas disease and there is still much to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs available, such as benznidazole and nifurtimox, they are not totally reliable and often toxic. A recently released negative clinical trial with benznidazole in patients with chronic Chagas cardiomyopathy further reinforces the concerns regarding its effectiveness. New drugs and new delivery systems, incl...
Source: Expert Review of Cardiovascular Therapy - February 17, 2016 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: the STOP-HF randomized Phase II trial
Conclusions The blinded placebo-controlled STOP-HF trial demonstrated the safety of a single endocardial administration of pSDF-1 but failed to demonstrate its primary endpoint of improved composite score at 4 months after treatment. Through a pre-specified analysis the STOP-HF trial demonstrates the potential for attenuating LV remodelling and improving EF in high-risk ischaemic cardiomyopathy. The safety profile supports repeat dosing with pSDF-1 and the degree of left ventricular remodelling suggests the potential for improved outcomes in larger future trials.
Source: European Heart Journal - September 1, 2015 Category: Cardiology Authors: Chung, E. S., Miller, L., Patel, A. N., Anderson, R. D., Mendelsohn, F. O., Traverse, J., Silver, K. H., Shin, J., Ewald, G., Farr, M. J., Anwaruddin, S., Plat, F., Fisher, S. J., AuWerter, A. T., Pastore, J. M., Aras, R., Penn, M. S. Tags: Heart failure/cardiomyopathy Source Type: research

Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease.
Abstract Adipose tissue-derived stem cells (ADSCs) are adult stem cells that can be easily harvested from subcutaneous adipose tissue. Many studies have demonstrated that ADSCs differentiate into vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), and cardiomyocytes in vitro and in vivo. However, ADSCs may fuse with tissue-resident cells and obtain the corresponding characteristics of those cells. If fusion occurs, ADSCs may express markers of VECs, VSMCs, and cardiomyocytes without direct differentiation into these cell types. ADSCs also produce a variety of paracrine factors such as vascular...
Source: World Journal of Cardiology - August 26, 2015 Category: Cardiology Authors: Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H Tags: World J Cardiol Source Type: research

Effects of Intracoronary Infusion of Escalating Doses of Cardiac Stem Cells in Rats With Acute Myocardial Infarction Original Articles
Conclusions— Surprisingly, in this rat model of acute myocardial infarction, the dose–response relationship for intracoronary CSCs is flat. A minimal dose between 0.3 and 0.75x106 is necessary for efficacy; above this threshold, a 4-fold increase in cell number does not produce greater improvement in LV function or structure. Further increases in cell dose are harmful.
Source: Circulation: Heart Failure - July 21, 2015 Category: Cardiology Authors: Tang, X.-L., Rokosh, G., Sanganalmath, S. K., Tokita, Y., Keith, M. C. L., Shirk, G., Stowers, H., Hunt, G. N., Wu, W., Dawn, B., Bolli, R. Tags: Animal models of human disease, Other Treatment, Acute myocardial infarction Original Articles Source Type: research

Stroke Rounds: The Next Big Thing
(MedPage Today) -- Best bets include flat panel CT, stem cells, and retrials of neuroprotectives.
Source: MedPage Today Cardiovascular - February 17, 2015 Category: Cardiology Source Type: news

Waking up the stem cell niche: how hematopoietic stem cells generate inflammatory monocytes after stroke.
PMID: 25634966 [PubMed - in process]
Source: Circulation Research - January 30, 2015 Category: Cardiology Authors: Wolf D, Ley K Tags: Circ Res Source Type: research

Stem Cell Factor Gene Transfer Improves Cardiac Function After Myocardial Infarction in Swine Original Articles
Conclusions— Local overexpression of SCF post-MI induces the recruitment of c-kit+ cells at the infarct border area acutely. In the chronic stages, SCF gene transfer was associated with improved cardiac function in a preclinical model of ischemic cardiomyopathy.
Source: Circulation: Heart Failure - January 20, 2015 Category: Cardiology Authors: Ishikawa, K., Fish, K., Aguero, J., Yaniz-Galende, E., Jeong, D., Kho, C., Tilemann, L., Fish, L., Liang, L., Eltoukhy, A. A., Anderson, D. G., Zsebo, K., Costa, K. D., Hajjar, R. J. Tags: Angiogenesis, Myogenesis, Other Treatment, Acute myocardial infarction Original Articles Source Type: research

Strategies for Early Stroke Recovery: What Lies Ahead?
Opinion statement Most patients experience some degree of recovery after a stroke, but the majority of patients still have persistent impairments months later. Most recovery occurs early after a stroke, in the first few weeks to months, corresponding to a period of enhanced neuroplasticity. We are beginning to understand the mechanisms that underlie this recovery process, and how we can take advantage of this plasticity in designing rehabilitative interventions. In this review, we focus on recent behavioral, pharmacological, and brain stimulation strategies that have shown promise in augmenting stroke recovery. S...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2014 Category: Cardiology Source Type: research

Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
Conclusions: Ischemic stroke activates hematopoietic stem cells via increased sympathetic tone, leading to a myeloid bias of hematopoiesis and higher bone marrow output of inflammatory Ly6Chigh monocytes. PMID: 25362208 [PubMed - as supplied by publisher]
Source: Circulation Research - October 31, 2014 Category: Cardiology Authors: Courties G, Herisson F, Sager H, Heidt T, Ye Y, Ying W, Sun Y, Severe N, Dutta P, Scharff J, Scadden D, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Tags: Circ Res Source Type: research

Clinical Research and the Development of Medical Therapeutics.
Abstract Clinical research plays a central role in the development of medical therapeutics, but the current system is estimated to take 10-15 years from initial discovery to regulatory approval, at a cost of approximately US$1 billion. Contrast the paths by which 2 anticoagulant options for atrial fibrillation were discovered and ultimately established as treatment options in clinical medicine. Warfarin was discovered by serendipity and compared with placebo in relatively small trials; this was associated with a low cost of development. The new oral anticoagulants were synthesized to provide highly specific, targe...
Source: Circulation Journal - May 16, 2014 Category: Cardiology Authors: Antman EM Tags: Circ J Source Type: research

Stem Cells Show Promise for Stroke Recovery
Title: Stem Cells Show Promise for Stroke RecoveryCategory: Health NewsCreated: 4/7/2014 4:36:00 PMLast Editorial Review: 4/8/2014 12:00:00 AM
Source: MedicineNet Heart General - April 8, 2014 Category: Cardiology Source Type: news

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