Filtered By:
Condition: Coronary Heart Disease
Therapy: Statin Therapy

This page shows you your search results in order of date. This is page number 8.

Order by Relevance | Date

Total 806 results found since Jan 2013.

Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China.
In conclusion, lower extremity PAD increased coronary heart disease and stroke risks in T2DM. PMID: 28607554 [PubMed - in process]
Source: International Journal of Endocrinology - June 14, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Beta-blockers 'useless' for many heart attack patients, study reports
Conclusion This study aimed to see whether beta blockers reduce mortality in people who've had a heart attack but who don't have heart failure or systolic dysfunction. It found no difference between those who were and those who were not given beta-blockers on discharge from hospital. The authors say this adds to the evidence that routine prescription of beta blockers might not be needed for patients without heart failure following a heart attack. Current UK guidelines recommend all people who have had a heart attack take beta blockers for at least one year to reduce risk of recurrent events. Only people with heart failure ...
Source: NHS News Feed - May 30, 2017 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Changes in the prevalence of statin use in Germany - findings from national health interview and examination surveys 1997-1999 and 2008-2011.
CONCLUSION: The increase in the prevalence of statin use in Germany between the two national health surveys (1997-1999 and 2008-2011) reflects the implementation of current guideline recommendations without evidence for inequalities according to gender, education, type of health insurance or region of residence. These population-based data add to information on statin prescription obtained from statutory health insurance data. Limitations of survey-based information derive from potential misclassification and selection bias as well as large time gaps between the survey periods. Further studies are needed to examine why the...
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - May 19, 2017 Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research

Racial differences in statin adherence following hospital discharge for ischemic stroke
Conclusions: Compared with white adults, black adults were more likely to be nonadherent to statins following hospitalization for ischemic stroke.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Albright, K. C., Zhao, H., Blackburn, J., Limdi, N. A., Beasley, T. M., Howard, G., Bittner, V., Howard, V. J., Muntner, P. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Low-gluten diet linked to heart attack risk
Conclusion This study has found that while overall gluten consumption in people without coeliac disease may not be related to heart disease risk, avoiding whole grains (wheat, barley and rye) in order to avoid gluten may be associated with increased heart disease risk. This study has several strengths, including its large size, the fact that data was collected prospectively and diet assessed at several time-points, the long period of follow up, and that it took into account a wide range of potential confounders. As with all studies of this type, it is possible that other factors may affect the results. However, the researc...
Source: NHS News Feed - May 4, 2017 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Economic evaluation of ezetimibe treatment in combination with statin therapy in the United States.
CONCLUSIONS: Compared with statin monotherapy, ezetimibe with statin therapy was cost-effective for secondary prevention of CHD and stroke and for primary prevention of these conditions in patients whose LDL-C level is ≥ 100 mg/dL and in patients with diabetes, taking into account a 90% cost reduction for ezetimibe. PMID: 28426345 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - April 22, 2017 Category: Health Management Tags: J Med Econ Source Type: research

Managing Cardiovascular Risk of Macrolides: Systematic Review and Meta-Analysis
ConclusionsMore studies are required to investigate the short-term cardiovascular outcomes associated with different types of macrolides. Future studies are warranted to evaluate the effect of statins for preventing excess acute cardiovascular events associated with clarithromycin or other macrolides.
Source: Drug Safety - April 10, 2017 Category: Drugs & Pharmacology Source Type: research

Use of Lipid-Modifying Therapy and LDL-C Goal Attainment in a High-Cardiovascular-Risk Population in the Netherlands.
This study investigates lipid-modifying therapy (LMT) and LDL-C goal attainment in a real-world, high-cardiovascular-risk population in the Netherlands. METHODS: From the PHARMO Database Network, patients aged ≥18 years with an LDL-C measurement in 2012 (index date) were selected and hierarchically classified into the following mutually exclusive high-cardiovascular-risk categories: familial hypercholesterolemia (FH), recent acute coronary syndrome (ACS), coronary heart disease, ischemic stroke, peripheral arterial disease, and diabetes mellitus. LMT use and LDL-C goal attainment at the index date was assessed. ...
Source: Clinical Therapeutics - March 24, 2017 Category: Drugs & Pharmacology Authors: Kuiper JG, Sanchez RJ, Houben E, Heintjes EM, Penning-van Beest FJ, Khan I, van Riemsdijk M, Herings RM Tags: Clin Ther Source Type: research

Decline in Cardiovascular Mortality: Possible Causes and Implications.
Abstract If the control of infectious diseases was the public health success story of the first half of the 20th century, then the decline in mortality from coronary heart disease and stroke has been the success story of the century's past 4 decades. The early phase of this decline in coronary heart disease and stroke was unexpected and controversial when first reported in the mid-1970s, having followed 60 years of gradual increase as the US population aged. However, in 1978, the participants in a conference convened by the National Heart, Lung, and Blood Institute concluded that a significant recent downtick in c...
Source: Circulation Research - January 19, 2017 Category: Cardiology Authors: Mensah GA, Wei GS, Sorlie PD, Fine LJ, Rosenberg Y, Kaufmann PG, Mussolino ME, Hsu LL, Addou E, Engelgau MM, Gordon D Tags: Circ Res Source Type: research

Patterns and predictors of lipid ‐lowering therapy in patients with atherosclerotic cardiovascular disease and/or diabetes mellitus in 2014: Insights from a large US managed‐care population
ConclusionsIn 2014, only 49% of patients with ASCVD and 40% with only DM had evidence for a filled statin prescription. Those with indications of ischemic stroke, PAD, and DM were less likely to receive statins than those with coronary conditions. Other characteristics such as advanced age, female sex, and noncardiac conditions predicted less statin utilization, thereby representing good targets for quality improvement.
Source: Clinical Cardiology - December 26, 2016 Category: Cardiology Authors: Dylan L. Steen, Irfan Khan, Laura Becker, JoAnne M. Foody, Katherine Gorcyca, Robert J. Sanchez, Robert P. Giugliano Tags: CLINICAL INVESTIGATIONS Source Type: research

Fibrates for primary prevention of cardiovascular disease events.
CONCLUSIONS: Moderate-quality evidence suggests that fibrates lower the risk for cardiovascular and coronary events in primary prevention, but the absolute treatment effects in the primary prevention setting are modest (absolute risk reductions < 1%). There is low-quality evidence that fibrates have no effect on overall or non-CVD mortality. Very low-quality evidence suggests that fibrates are not associated with increased risk for adverse effects. PMID: 27849333 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 15, 2016 Category: Journals (General) Authors: Jakob T, Nordmann AJ, Schandelmaier S, Ferreira-González I, Briel M Tags: Cochrane Database Syst Rev Source Type: research

Genetic and Non-Genetic Determinants of the Pharmacological Activity of Statins.
Abstract Statins are cholesterol-lowering agents which belong to the group of the most commonly prescribed drugs. The use of statins has become the standard treatment in patients with an increased risk of cardiovascular and coronary heart diseases. However, many clinical studies have shown that 13 - 75% of patients fail to achieve LDL-cholesterol and total cholesterol target levels. The clinical implications of insufficient response include cardiovascular complications caused by atherosclerosis leading to acute myocardial infarction, stroke and death. The mechanism underlying statin resistance has been associated ...
Source: Current Drug Metabolism - September 18, 2016 Category: Drugs & Pharmacology Authors: Karaźniewicz-Łada M, Główka A, Mikołajewski J, Przysławski J Tags: Curr Drug Metab Source Type: research

Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging Study
Conclusions: In this longitudinal sample of older men, the findings supported the hypothesis that long-term PM2.5 exposure negatively affects renal function and increases renal function decline. Citation: Mehta AJ, Zanobetti A, Bind MC, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. 2016. Long-term exposure to ambient fine particulate matter and renal function in older men: the VA Normative Aging Study. Environ Health Perspect 124:1353–1360; http://dx.doi.org/10.1289/ehp.1510269 Address correspondence to A.J. Mehta, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Landmark Ce...
Source: EHP Research - September 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article September 2016 Source Type: research

UK heart disease and stroke death rates now lower than cancer
Conclusion This valuable research informs on the burden of cardiovascular disease and associated mortality across European countries. It demonstrates that CVD is still the most common cause of death across Europe, but rates have been falling over the past 10 years. This fall means that in several European countries, including the UK, cancer rates now overtake CVD death rates in men. Generally, CVD disability and burden of disease seems to be greater in Eastern European countries. The WHO mortality data and population data are quite up-to-date and should be reliable, though as the researchers say, there was a lack of high ...
Source: NHS News Feed - August 15, 2016 Category: Consumer Health News Tags: Heart/lungs Cancer Neurology Source Type: news

Rosuvastatin decreases testosterone levels but not sexual function in men with type 2 diabetes
Type 2 diabetes is often associated with hypertension and dyslipidemia. Because dyslipidemia exacerbates macrovascular disease, including coronary heart disease, stroke, and peripheral vascular disease, lipid lowering therapy is indicated for patients with type 2 diabetes, because lipid lowering therapy has been found to greatly reduce cardiovascular events in this population [1]. Statin use, however, can lead to reduced hepatic synthesis of cholesterol by inhibiting 3-hydroxy-methylglutaryl-CoA reductase.
Source: Diabetes Research and Clinical Practice - August 5, 2016 Category: Endocrinology Authors: Ching Jung Hsieh, Bin Huang Source Type: research