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Specialty: Transplant Surgery
Procedure: Perfusion

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Total 17 results found since Jan 2013.

Expanded Criteria Donors
Exp Clin Transplant. 2022 Aug;20(Suppl 4):13-19. doi: 10.6002/ect.DonorSymp.2022.L13.ABSTRACTThe expanded criteria donor is any donor over the age of 60 years or a donor over the age of 50 years with 2 of the following 3 items: (1) history of high blood pressure, (2) serum creatinine ≥1.5 mg/dL, and (3) death due to stroke. To accept an expanded criteria donor kidney may significantly decrease the amount of time a person waits for transplant but requires written informed consent from the recipient. Although expanded criteria donor kidneys have predictably shorter outcomes than standard criteria donors, the exact risk is ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - August 26, 2022 Category: Transplant Surgery Authors: Hassan Argani Source Type: research

Improvement in Right Ventricular Stroke Work Index in Cardiogenic Shock Associated with Excellent Durable Left Ventricular Assist Implantation Results
Cardiogenic shock results from inadequate cardiac output to satisfy organ perfusion with potential need for pharmacologic and mechanical circulatory support for survival. Impella 5.0 insertion is used as a rescue device and bridge to durable mechanical circulatory support. We sought to evaluate changes in right ventricular parameters in patients bridged with Impella 5.0 undergoing durable left ventricular device implantation (LVAD).
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: M.P. Rogers, B.D. Mackie, R.L. Hooker Tags: (447) Source Type: research

Comparing Donor Heart Assessment Strategies During Ex Situ Heart Perfusion to Better Estimate Posttransplant Cardiac Function
Conclusions. Left ventricular functional parameters, especially ventricular work and reserve, provided the best estimation of myocardial performance following transplantation. Furthermore, simple NI estimates of ventricular function proved useful in this setting. Right ventricular and metabolic measurements were limited in their ability to correlate with myocardial recovery. This emphasizes the need for an ESHP platform capable of assessing myocardial contractility and suggests that metabolic parameters alone do not provide a reliable evaluation.
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Type II Minimal ‐Invasive Extracorporeal Circuit for Aortic Valve Replacement: A Randomized Controlled Trial
Abstract Extracorporeal circulation triggers systemic inflammatory response and coagulation disorders which may lead to unfavorable clinical outcome. A type II minimally‐invasive extracorporeal circuit (MiECC) is a closed system with markedly reduced artificial surface as compared to conventional extracorporeal circuits (CECC). The aim of this study was to investigate and compare inflammatory responses, complement activation and selected clinical end‐points in isolated surgical aortic valve replacement (SAVR) performed with a type II MiECC circuit or a CECC. Fifty patients were prospectively randomized to MiECC or CECC...
Source: Artificial Organs - February 12, 2018 Category: Transplant Surgery Authors: Erich Gygax, Hans ‐Ulrich Kaeser, Mario Stalder, Brigitta Gahl, Robert Rieben, Thierry Carrel, Gabor Erdoes Tags: Main Text Source Type: research

Challenges managing end ‐stage renal disease and kidney transplantation in a child with MTFMT mutation and moyamoya disease
We describe a four‐yr‐old female with features of moyamoya disease referred to our center for kidney transplant evaluation with ESRD secondary to presumed renal dysplasia along with concern for cerebral vascular anomalies. With her constellation of organ involvement, a genetic workup revealed a homozygous, frameshift mutation in the mitochondrial methionyl‐tRNA formyltransferase gene. Given her vascular anomalies and evidence of prior infarcts seen on cerebral imaging, it was felt that her risk of future stroke events was high and that hypotension or intravascular volume depletion would further exacerbate this risk. ...
Source: Pediatric Transplantation - July 7, 2016 Category: Transplant Surgery Authors: Aris Oates, Jessica Brennan, Anne Slavotinek, Adnan Alsadah, Daniel Chow, Marsha M. Lee Tags: Case Report Source Type: research

Challenges managing end‐stage renal disease and kidney transplantation in a child with MTFMT mutation and moyamoya disease
We describe a four‐yr‐old female with features of moyamoya disease referred to our center for kidney transplant evaluation with ESRD secondary to presumed renal dysplasia along with concern for cerebral vascular anomalies. With her constellation of organ involvement, a genetic workup revealed a homozygous, frameshift mutation in the mitochondrial methionyl‐tRNA formyltransferase gene. Given her vascular anomalies and evidence of prior infarcts seen on cerebral imaging, it was felt that her risk of future stroke events was high and that hypotension or intravascular volume depletion would further exacerbate this risk. ...
Source: Pediatric Transplantation - July 7, 2016 Category: Transplant Surgery Authors: Aris Oates, Jessica Brennan, Anne Slavotinek, Adnan Alsadah, Daniel Chow, Marsha M. Lee Tags: Case Report Source Type: research

Circulating Histone-Induced Lung Injury: A Novel Model of Damaged Lungs From Brain-Dead Donors
Histones, a component of nucleosomes, are released from dying cells into the blood circulation in patients with stroke. It has been also known that circulating histones can cause endothelial injury of the pulmonary vasculature. We hypothesized that a transient release of histones in the circulation cause endothelial damages in the brain-dead donor lungs that can lead severe re-perfusion injury after lung transplantation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: T. Murayama, M. Anraku, T. Murakawa, T. Yoshioka, M. Inui, N. Hiyama, M. Kawashima, T. Tsuchiya, J. Ichinose, H. Hino, K. Nagayama, J. Nitadori, K. Kakimi, J. Nakajima Source Type: research

Similar Cerebral Protective Effectiveness of Antegrade and Retrograde Cerebral Perfusion During Deep Hypothermic Circulatory Arrest in Aortic Surgery: A Meta‐Analysis of 7023 Patients
Abstract In aortic arch surgery, deep hypothermic circulatory arrest (DHCA) combined with cerebral perfusion is employed worldwide as a routine practice. Even though antegrade cerebral perfusion (ACP) is more widely used than retrograde cerebral perfusion (RCP), the difference in benefit and risk between ACP and RCP during DHCA is uncertain. The purpose of this meta‐analysis is to compare neurologic outcomes and early mortality between ACP and RCP in patients who underwent aortic surgery during DHCA. PubMed, EMBASE, and the Cochrane Library were searched using the key words “antegrade,” “retrograde,” “cerebral ...
Source: Artificial Organs - March 4, 2015 Category: Transplant Surgery Authors: Shasha Guo, Yanhua Sun, Bingyang Ji, Jinping Liu, Guyan Wang, Zhe Zheng Tags: Main Text Article Source Type: research

Can Stroke Volume Variation Be an Alternative to Central Venous Pressure in Patients Undergoing Kidney Transplantation?
Stroke volume variation (SVV) is known to be a simple and less invasive hemodynamic parameter for evaluating fluid responsiveness and preload status. Central venous pressure (CVP) has been targeted to achieve an adequate level for improving the graft perfusion and long-term graft function in kidney transplantation (KT) recipients, despite the various potential complications. The aim of this study was to investigate whether SVV could substitute for CVP in guiding intravascular volume management during KT.
Source: Transplantation Proceedings - December 1, 2014 Category: Transplant Surgery Authors: J.-H. Chin, I.-G. Jun, J. Lee, H. Seo, G.-S. Hwang, Y.-K. Kim Tags: Frontiers in Transplantation Source Type: research

Effects of Antegrade and Retrograde Machine Perfusion Preservation on Cardiac Function After Transplantation in Canines
Abstract: Introduction: Most studies investigating machine perfusion preservation for heart transplantation perfuse through the aortic root (antegrade), but the coronary sinus (retrograde) is a potential option. We hypothesized that retrograde machine perfusion provides better functional protection than static storage, while avoiding the potential irregular perfusion seen when aortic insufficiency occurs with antegrade perfusion.Materials and Methods: Eighteen canine donor hearts were arrested, procured, and stored in modified Celsior solution for 4 hours by using either static storage at 0°C to 4°C (n = 6) or machine p...
Source: Transplantation Proceedings - June 1, 2014 Category: Transplant Surgery Authors: S.M. Brant, D.H. Rosenbaum, M.L. Cobert, L.M. West, M.E. Jessen, M. Peltz Tags: Experimental Transplantation Source Type: research

RNase A in (Xeno)Transplantation
ConclusionsRNase A significantly improved graft survival. On the basis of these sweeping results, however, we suppose that RNase A could be an important adjuvant drug not only in allotransplantation but even in xenotransplantation. References[1] Fischer S, Gerriets T, Wessels C, et al. Extracellular RNA mediates endothelial‐cell permeability via vascular endothelial growth factor. Blood 2007; 110(7): 2457–2465.[2] Kannemeier C, Shibamiya A, Nakazawa F, et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci U S A 2007; 104(15): 6388–6393.[3] Fischer S, Grantzow T,...
Source: Xenotransplantation - April 19, 2014 Category: Transplant Surgery Authors: Eike Kleinert, Bruno Reichart, Tanja Mayr, Jan‐Michael Abicht, Paolo Brenner, Christian Hagl, Martin Langenmayer, Ruediger Wanke, Elisabeth Deindl, Sonja Guethoff Tags: Program and Abstracts Source Type: research

Analysis of Pressure Head‐Flow Loops of Pulsatile Rotodynamic Blood Pumps
In this study, the impact of these parameters upon the heart‐RBP interaction was examined in terms of the pressure head‐flow (HQ) diagram. The measurements were conducted using a rotodynamic Deltastream DP2 pump in a validated hybrid mock circulation with baroreflex function. The pump was operated with a sinusoidal speed profile, synchronized to the native cardiac cycle. The simulated ventriculo‐aortic cannulation showed that the level of (un)loading and the shape of the HQ loops strongly depend on the phase shift. The HQ loops displayed characteristic shapes depending on the phase shift. Increased contribution of na...
Source: Artificial Organs - July 1, 2013 Category: Transplant Surgery Authors: Silje E. Jahren, Gregor Ochsner, Fangjun Shu, Raffael Amacher, James F. Antaki, Stijn Vandenberghe Tags: Main Text Article Source Type: research