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Recurrent Atherosclerotic Cardiovascular Disease Events Potentially Prevented with Guideline-Recommended Cholesterol-Lowering Therapy following Myocardial Infarction
ConclusionImplementation of guideline-recommended cholesterol-lowering therapy could prevent a substantial percentage of recurrent ASCVD events.
Source: Cardiovascular Drugs and Therapy - April 13, 2023 Category: Cardiology Source Type: research

Cardiovascular Risk and Treatment Outcomes in Severe Hypercholesterolemia: A Nationwide Cohort Study
Conclusions Using large Korean cohort data, our study proved incrementally elevated cardiovascular risk and clinical benefit associated with LDL-C<100 mg/dL in individuals with severe hypercholesterolemia. These results support aggressive lipid lowering and provide evidence for the LDL-C target in this population.PMID:35470675 | DOI:10.1161/JAHA.121.024379
Source: Atherosclerosis - April 26, 2022 Category: Cardiology Authors: Chan Joo Lee Sanghyun Park Kyungdo Han Sang-Hak Lee Source Type: research

Moderate-Intensity Statins Plus Ezetimibe vs. High-Intensity Statins After Coronary Revascularization: A Cohort Study
ConclusionsPatients undergoing a coronary revascularization procedure who received moderate-intensity statins plus ezetimibe showed similar rates of major adverse cardiovascular events as patients who received high-intensity statins.
Source: Cardiovascular Drugs and Therapy - September 17, 2021 Category: Cardiology Source Type: research

Mildly Abnormal Lipid Levels, but Not High Lipid Variability, Are Associated with Increased Risk of Myocardial Infarction and Stroke in 'Statin-Naive' Young Population: A Nationwide Cohort Study.
Conclusions: Mildly abnormal baseline lipid levels were associated with an increased future risk of ASCVD events, particularly MI, whereas measures of lipid variability were not. Therefore, in young adults, achieving optimal lipid levels could be valuable in the prevention of ASCVD. PMID: 31978313 [PubMed - as supplied by publisher]
Source: Circulation Research - January 23, 2020 Category: Cardiology Authors: Park JB, Kim D, Lee H, Hwang IC, Yoon YE, Park HE, Choi SY, Kim YJ, Cho GY, Han KD, Kim HK Tags: Circ Res Source Type: research

Efficacy and Safety of High-intensity Statins in Patients with Acute Myocardial Infarction: An Asian Perspective
ConclusionsAMI patients in Taiwan with HIS had similar clinical outcomes to those with non-HIS. Using HIS for effective reduction of low-density lipoprotein cholesterol is safe in Taiwan.
Source: Canadian Journal of Cardiology - November 2, 2019 Category: Cardiology Source Type: research

Statin adherence and persistence on secondary prevention of cardiovascular disease in Taiwan
Conclusions Good adherence and persistence to statin therapy are significantly associated with lower risk of secondary ASCVD rehospitalisation and in-hospital death.
Source: Heart Asia - September 2, 2019 Category: Cardiology Authors: Shau, W.-Y., Lai, C.-L., Huang, S.-T., Chen, S.-T., Li, J. Z., Fung, S., Tse, V. C., Lai, M.-S. Tags: Original research Source Type: research

Differences in statin utilization and lipid lowering by race, ethnicity, and HIV status in a real-world cohort of persons with human immunodeficiency virus and uninfected persons
ConclusionsAmong PWH with statin indication(s), blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin used for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - January 25, 2019 Category: Cardiology Source Type: research

Differences in Statin Utilization and Lipid-Lowering by Race, Ethnicity, and HIV Status in a Real-World Cohort of Persons with Human Immunodeficiency Virus and Uninfected Persons
ConclusionsAmong PWH with statin indication(s), Blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin utilized for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

Abstract 131: Recurrent Acute Cardiovascular Events and Statin Use Session Title: Poster Session AM
Conclusion: While statin use substantially increased after an index CV event, nearly 40% of patients remained untreated, increasing their recurrent CV event risk by 76%. Initiation and continuation of statin therapy after CV events remains a large public health opportunity for patients with ASCVD.
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Tecson, K. M., Kluger, A. Y., DiMario, S., Harrison, D. J., McCullough, P. A. Tags: Session Title: Poster Session AM Source Type: research

Statin Adherence After Ischemic Stroke or Transient Ischemic Attack Is Associated With Clinical Outcome.
CONCLUSIONS: Good statin adherence was associated with better clinical outcome in patients with acute ischemic stroke or TIA. PMID: 26742588 [PubMed - as supplied by publisher]
Source: Circulation Journal - January 8, 2016 Category: Cardiology Authors: Chen PS, Cheng CL, Kao Yang YH, Li YH Tags: Circ J Source Type: research

Changing Cholesterol Levels and Coronary Heart Disease Risk.
Abstract A report by Colantonio and colleagues in this issue of Circulation describes the relations between serum lipoprotein cholesterol levels and triglycerides with coronary heart disease (CHD) incidence.(1) Their analyses draw upon the experience of three American population samples of adults with 8.9 years of follow up. The first study group is the Reasons for Geographic and Racial Differences in Stroke (REGARDS, National Institutes of Health observational cohort, baseline 2003-2007), the second investigation is the Atherosclerosis Risk in Communities (ARIC, National Heart, Lung and Blood observational cohort...
Source: Circulation - December 9, 2015 Category: Cardiology Authors: Wilson PW Tags: Circulation Source Type: research

Association of Patient Enrollment in Medicare Part D With Outcomes After Acute Myocardial Infarction Original Articles
Conclusions— Only half of Medicare-insured patients with AMI were enrolled in Part D by hospital discharge, and their 30-day and 1-year adjusted outcomes did not differ substantially from nonenrollees. There remain opportunities for improvement in medication adherence among patients with prescription drug coverage.
Source: Circulation: Cardiovascular Quality and Outcomes - November 17, 2015 Category: Cardiology Authors: Goyal, A., de Lemos, J. A., Peng, S. A., Thomas, L., Amsterdam, E. A., Hockenberry, J. M., Peterson, E. D., Wang, T. Y. Tags: Myocardial Infarction, Ethics and Policy, Quality and Outcomes Original Articles Source Type: research

Risk of Intracranial Hemorrhage from Statin Use in Asians: A Nationwide Cohort Study.
CONCLUSIONS: -Generally, no association was observed between cumulative statin use and risk of ICH among subjects without a prior history of stroke. An increased risk was identified among the non-hypertensive cohort, but this finding should be interpreted with caution. PMID: 25858194 [PubMed - as supplied by publisher]
Source: Circulation - April 9, 2015 Category: Cardiology Authors: Chang CH, Lin CH, Caffrey JL, Lee YC, Liu YC, Lin JW, Lai MS Tags: Circulation Source Type: research

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