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Specialty: Cardiology
Condition: Dementia

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Total 319 results found since Jan 2013.

Abstract 135: Complementary-Medicine Prevention of Alzheimers Disease by Blackcurrant Extract Session Title: Abstract Poster Session I and Reception
Conclusion: The flow experiments show that membrane filtered BCE clearly improved endothelial function by an additional NO release, while ethanol extracted did not. This vasodilatation together with the reduction of Alzheimer nanoplaques may have a beneficial effect on cognitive functions in dementiae of the Alzheimer type, in prevention of TIA and stroke.
Source: Circulation: Cardiovascular Quality and Outcomes - February 26, 2016 Category: Cardiology Authors: Siegel, G., Mockenhaupt, F. H. M., Pircher, A., Ermilov, E., Hammersen, S. Tags: Session Title: Abstract Poster Session I and Reception Source Type: research

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans Stroke
Conclusions The GCAS model successfully generated gradual and continuous CBF reduction over 28 days, with replication of key histological, radiological, and behavioral features associated with cerebral hypoperfusion leading to VCI.
Source: JAHA:Journal of the American Heart Association - February 22, 2016 Category: Cardiology Authors: Hattori, Y., Enmi, J.-i., Iguchi, S., Saito, S., Yamamoto, Y., Tsuji, M., Nagatsuka, K., Kalaria, R. N., Iida, H., Ihara, M. Tags: Animal Models of Human Disease, Cerebrovascular Disease/Stroke, Cognitive Impairment, Atherosclerosis, Stenosis Source Type: research

Cerebral Small Vessel Disease and Arterial Stiffness: Tsunami Effect in the Brain
Background: Cerebral small vessel diseases, including silent lacunar infarcts, white matter hyperintensities, and microbleeds, pose a risk for cerebrovascular disease, cognitive impairment, and the geriatric syndrome via effects on arterial stiffness. However, the vascular, physiological, and metabolic roles of arterial stiffness in cerebral small vessel diseases remain unclear. Summary: Arterial stiffness can be assessed using various indicators such as the ankle-brachial index, pulse wave velocity, cardio-ankle vascular index, and augmentation index. Arterial stiffness is independently associated with all components of c...
Source: Pulse - January 20, 2016 Category: Cardiology Source Type: research

Cerebral Small Vessel Disease and Arterial Stiffness: Tsunami Effect in the Brain?
Background: Cerebral small vessel diseases, including silent lacunar infarcts, white matter hyperintensities, and microbleeds, pose a risk for cerebrovascular disease, cognitive impairment, and the geriatric syndrome via effects on arterial stiffness. However, the vascular, physiological, and metabolic roles of arterial stiffness in cerebral small vessel diseases remain unclear. Summary: Arterial stiffness can be assessed using various indicators such as the ankle-brachial index, pulse wave velocity, cardio-ankle vascular index, and augmentation index. Arterial stiffness is independently associated with all components of c...
Source: Pulse - January 19, 2016 Category: Cardiology Source Type: research

Antithromboembolic strategies in atrial fibrillation: A review.
Abstract Oral anticoagulation is highly effective for stroke prevention in high-risk-patients with atrial fibrillation. AF is also a risk for dementia, and effective OAC reduces the risk of dementia. Up to 30% of patients with atrial fibrillation have a coronary artery disease and antiplatelets are used to avoid thrombotic complications]. Patients with atrial fibrillation oft have an acute coronary syndrome und undergo a percutaneous intervention with stent-implantation. These patients require a triple therapy, i.e. the combination of oral anticoagulation with dual-anti-platelet therapy. It is obvious that OAC may...
Source: Cardiology Journal - January 18, 2016 Category: Cardiology Authors: Cocco G, Amiet P, Jerie P Tags: Cardiol J Source Type: research

The Role of MicroRNAs in Antiarrhythmic Therapy for Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia experienced in clinical practice, and is responsible for significant morbidity and mortality.1 It affects more than 6 million people in Europe.1 The lifetime risk of developing AF after the age of 40 is approximately 25 %.1 AF is a major public health burden as it is associated with an increased risk of stroke by fivefold, dementia by twofold, heart failure by threefold and mortality by twofold.1,2
Source: Radcliffe Cardiology - December 1, 2015 Category: Cardiology Authors: mehul Source Type: research

N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives Imaging
Conclusions N-glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Vilar-Bergua, A., Riba-Llena, I., Vanhooren, V., Dewaele, S., Libert, C., Penalba, A., Montaner, J., Delgado, P. Tags: Imaging Source Type: research

The power of P in the elderly: Small biphasic wave, big impact
With increasing life expectancy, the Beatles song “When I’m Sixty-Four” could be changed to “When I’m Ninety-Four” soon. Dementia and stroke, some of the most feared conditions in old age, are often caused by silent atrial fibrillation1,2 and may be heralded by changes in the P wave as suggested in the study by Martinez-Selles et al3 in this issue of HeartRhythm. The authors focus on P waves in centenarians over a century after the first description of the P wave. The authors report observations on interatrial block in centenarians, with implications well beyond this population.
Source: Heart Rhythm - November 18, 2015 Category: Cardiology Authors: Larissa Fabritz Tags: Editorial Commentary Source Type: research

Abstract P157: Tractography of White Matter Connections Predicts for Vascular Cognitive Impairment in Hypertensive Patients Session Title: Cerebrovascular Disease and Stroke
In this study, we used DTI and cognitive assessment (CA), in order to identify a regional pattern of fractional anisotropy (FA) changes that could predict for VCI in hypertensive patients (HT).We have examined 15 HT (moderate to severe, with antihypertensive medications) vs 15 normotensive (NT), subjecting them to DTI and CA. HT had significant higher SBP (138±4 vs 118±3 in NT) and DBP (87±2 vs 75±2 in NT) (p<0.001), displayed a significant LV hypertrophic remodeling (LVM/BSA 112±5 vs 83±3 for NT) (p<0.0001), with a significant moderate increase in albuminuria (15.7±2....
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Carnevale, L., Selvetella, G., Cugino, D., Grillea, G., Lembo, G., Carnevale, D. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Stroke Rounds: Dementia Risk Higher in Afib (CME/CE)
(MedPage Today) -- Association independent of stroke in 20-year longitudinal study
Source: MedPage Today Cardiovascular - September 22, 2015 Category: Cardiology Source Type: news

Percent Time With a Supratherapeutic INR in Atrial Fibrillation Patients Also Using an Antiplatelet Agent is Associated With Long‐Term Risk of Dementia
Conclusion: In AF patients receiving antiplatelet and anticoagulant therapies, the percent of time exposed to over anticoagulation increased dementia risk. These data support the possibility of chronic cerebral injury from microbleeds as a mechanism underlying the association of AF and dementia.This article is protected by copyright. All rights reserved
Source: Journal of Cardiovascular Electrophysiology - August 13, 2015 Category: Cardiology Authors: Victoria Jacobs, Scott C. Woller, Scott M. Stevens, Heidi T. May, Tami L. Bair, Brian G. Crandall, Michael Cutler, John D. Day, J. Peter Weiss, Jeffrey S. Osborn, Charles Mallender, Jeffrey L. Anderson, T. Jared Bunch Tags: Original Source Type: research

Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor
Proper perfusion is vital for maintenance of neuronal homeostasis and brain function. Changes in the function and structure of cerebral parenchymal arterioles (PAs) could impair blood flow regulation and increase the risk of cerebrovascular diseases, including dementia and stroke. Hypertension alters the structure and function of large cerebral arteries, but its effects on PAs remain unknown. We hypothesized that hypertension increases myogenic tone and induces inward remodeling in PAs; we further proposed that antihypertensive therapy or mineralocorticoid receptor (MR) blockade would reverse the effects of hypertension. P...
Source: AJP: Heart and Circulatory Physiology - July 1, 2015 Category: Cardiology Authors: Pires, P. W., Jackson, W. F., Dorrance, A. M. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research

Riser Blood Pressure Pattern Is Associated With Mild Cognitive Impairment in Heart Failure Patients.
CONCLUSIONS: The riser pattern was associated with mild CI in HF patients. An abnormal circadian BP rhythm in HF patients is clinically significant as a potential indicator of subclinical brain damage. PMID: 26066331 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - June 11, 2015 Category: Cardiology Authors: Komori T, Eguchi K, Saito T, Nishimura Y, Hoshide S, Kario K Tags: Am J Hypertens Source Type: research

Pulse Pressure and Cognitive Decline in Stroke Patients With White Matter Changes
The authors hypothesized that both high and low pulse pressure (PP) may predict cognitive decline in stroke/transient ischemic attack (TIA) patients with white matter changes (WMCs). The authors prospectively followed up 406 ischemic stroke/TIA patients with confluent WMCs over 18 months. PP was measured at 3 to 6 months after stroke/TIA and categorized into four groups by quartile. Cognition was assessed 3 to 6 months and 15 to 18 months after stroke/TIA using the Clinical Dementia Rating and Mini‐Mental State Examination (MMSE). Logistic regression showed that patients in the first quartile of PP had a 5.9‐fold h...
Source: The Journal of Clinical Hypertension - June 1, 2015 Category: Cardiology Authors: Zhaolu Wang, Adrian Wong, Wenyan Liu, Jie Yang, Winnie C.W. Chu, Lisa Au, Alexander Lau, Yunyun Xiong, Vincent C.T. Mok Tags: Original Paper Source Type: research