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Specialty: Cardiology
Condition: Dementia

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Total 319 results found since Jan 2013.

Is the brain an early or late component of essential hypertension?
Abstract The brain's relationship to essential hypertension is primarily understood to be that of an end-organ, damaged late in life by stroke or dementia. Emerging evidence, however, shows that heightened blood pressure (BP) early in life and prior to traditionally defined hypertension, relates to altered brain structure, cerebrovascular function, and cognitive processing. Deficits in cognitive function, cerebral blood flow (CBF) responsivity, volumes of brain areas, and white matter integrity all relate to increased but pre-hypertensive levels of BP. Such relationships may be observed as early as childhood. In t...
Source: American Journal of Hypertension - March 13, 2020 Category: Cardiology Authors: Jennings JR, Muldoon MF, Sved AF Tags: Am J Hypertens Source Type: research

The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study.
CONCLUSIONS: Higher CAC scores were associated with higher odds of lacunar infarction, DSWMH, and ICAS. The presence and degree of CAC may be a useful indicator for SCVDs involving small and large vessels. PMID: 31969522 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - January 25, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Biomarkers in the risk assessment for stroke and dementia in atrial fibrillation
Purpose of review Atrial fibrillation is one of the most common clinically encountered arrhythmias exhibiting a strong association with a spectrum of cerebral injuries from the occurrence of clinical stroke, subclinical stroke, dementia, and cognitive decline. Dynamic noninvasive specific and sensitive diagnostic tests may allow a personalized approach to the atrial fibrillation patient's treatment based upon quantitative parameters, aiming to prevent or delay stroke, dementia, progressive cognitive decline, or to assess responses to these therapies. This review will explore molecular markers that have been shown to have...
Source: Current Opinion in Cardiology - January 1, 2020 Category: Cardiology Tags: ARRHYTHMIAS: Edited by Wilber W. Su Source Type: research

Prescription status of oral anticoagulants in patients with acute cerebral infarction with non-valvular atrial fibrillation at the time of stroke onset.
CONCLUSION: Our findings indicate that OAC prescription is affected by a previous history of cerebral infarction, a history of dementia, concurrent use of antiplatelet drugs, and whether the patient visits a specialist. PMID: 31843290 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - December 12, 2019 Category: Cardiology Authors: Deguchi I, Osada T, Takao M Tags: J Cardiol Source Type: research

Blood-Brain Barrier Transcytosis Genes, Risk Of Dementia And Stroke - A Prospective Cohort Study If 74,754 Individuals
Background and Aims: Dementias are devastating neurodegenerative diseases with nearly 50 million people affected worldwide. There are no available curative treatments, and large parts of the underlying biology remain unknown. Clinically, Alzheimer ’s disease often coexists with cerebral vascular diseases, and the major pathological hallmark of Alzheimer’s disease is accumulation of amyloid-β in the brain and in cerebral vessels.
Source: Atherosclerosis - August 2, 2019 Category: Cardiology Authors: I. Rasmussen, A. Tybjaerg-Hansen, K. Rasmussen, B. Nordestgaard, R. Frikke-Schmidt Tags: E-poster session Source Type: research

AF, Carotid Disease Synergistic for Risks for Stroke, Dementia AF, Carotid Disease Synergistic for Risks for Stroke, Dementia
Patients with vascular disease and prior stroke may be less likely referred for AF ablation, ' but our results suggest that these sicker patients may actually gain the most benefit from AF ablation. 'Medscape Medical News
Source: Medscape Cardiology Headlines - July 29, 2019 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Subclinical Cerebrovascular Disease: Epidemiology and Treatment
AbstractPurpose of ReviewSubclinical cerebrovascular disease (sCVD) is highly prevalent in older adults. The main neuroimaging findings of sCVD include white matter hyperintensities and silent brain infarcts on T2-weighted MRI and cerebral microbleeds on gradient echo or susceptibility-weighted MRI. In this paper, we will review the epidemiology of sCVD, the current evidence for best medical management, and future directions for sCVD research.Recent FindingsNumerous epidemiologic studies show that sCVD, in particular WMH, is an important risk factor for the development of dementia, stroke, worse outcomes after stroke, gait...
Source: Current Atherosclerosis Reports - July 26, 2019 Category: Cardiology Source Type: research

Determinants of systemic hypertension in older adults in Africa: a systematic review
An estimated 55% of older adults in Africa have systemic hypertension, a major risk factor for stroke, heart failure and dementia in the region. The risk factors associated with hypertension in this population...
Source: BMC Cardiovascular Disorders - July 22, 2019 Category: Cardiology Authors: William Kofi Bosu, Justice Moses Kwaku Aheto, Eugenio Zucchelli and Siobhan Theresa Reilly Tags: Research article Source Type: research

Epidemiology of Vascular Dementia.
Abstract The notion of what qualifies as vascular dementia has varied greatly since the first mention of dementia after apoplexy in ancient literature. Current insight points towards a multifactorial cause of cognitive decline at old age, in which vascular components like atherosclerosis, arterio(lo)sclerosis, (micro)infarcts, and amyloid angiopathy play an important role alongside other markers of neurodegeneration. Cerebrovascular disease will be present in most individuals with dementia, but-just like other causes-rarely a cause on its own. The consequent limitations of nosology may be alleviated by addition of...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 10, 2019 Category: Cardiology Authors: Wolters FJ, Ikram MA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Stroke and Dementia Risk in Patients with and without Atrial Fibrillation and Carotid Arterial Disease
We sought to understand the risks of stroke, transient ischemic attack(TIA), and dementia in patients with and without atrial fibrillation (AF) and carotid arterial disease (CD), or a combination of both, and determine if therapies for each disease may influence risks. 11,572 patients were included and matched into 4 groups of 2,893 by the presence of AF and CD. CD and AF augment risk of stroke/TIA and dementia in the general population and the coexistence of both diseases is additive in risk. Ablation of AF was associated with lower risk, the magnitude of which was greater in those with CD.
Source: Heart Rhythm - July 8, 2019 Category: Cardiology Authors: T. Jared Bunch, Tami L. Bair, Brian G. Crandall, Michael J. Cutler, John D. Day, Kevin G. Graves, Victoria Jacobs, Charles Mallender, Jeffrey S. Osborn, J. Peter Weiss, Heidi T. May Source Type: research

Maternal Stroke: an Update
AbstractPurpose of the ReviewMaternal morbidity and mortality is rising in the USA, and maternal stroke is a major contributor. Here, we review the epidemiology, risk factors, and current recommendations for diagnosis and acute treatment of ischemic and hemorrhagic stroke during pregnancy and postpartum, focusing on recent evidence.Recent FindingsThe incidence of maternal stroke has risen in recent years, possibly due to increasing rates of hypertensive disorders of pregnancy. The risk of maternal stroke is highest in the peripartum and early postpartum period. Preeclampsia is highly associated with reversible cerebral vas...
Source: Current Atherosclerosis Reports - June 21, 2019 Category: Cardiology Source Type: research

A-Fib Can Raise Dementia Risk, Even in Absence of Stroke
Title: A-Fib Can Raise Dementia Risk, Even in Absence of StrokeCategory: Health NewsCreated: 6/18/2019 12:00:00 AMLast Editorial Review: 6/19/2019 12:00:00 AM
Source: MedicineNet Heart General - June 19, 2019 Category: Cardiology Source Type: news

Revisiting the risks of incident atrial fibrillation: a narrative review. Part 2.
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with increasing incidence worldwide. Much focus has been directed towards AF prevention, given the morbidity and mortality from stroke, heart failure, and dementia. There are a number of common conditions associated with the onset of AF including, but not limited to, increased alcohol consumption, body weight, exercise, and stress. To reduce the incidence of AF, public health campaigns and targeted patient interventions may be warranted to promote balanced alcohol intake, appropriate exercise, and stress management to prevent AF and ...
Source: Polish Heart Journal - May 23, 2019 Category: Cardiology Authors: Panchal G, Mahmood M, Lip GYH Tags: Kardiol Pol Source Type: research

Blinded Randomized trial of Anticoagulation to prevent Ischemic stroke and Neurocognitive impairment in AF (BRAIN-AF): Methods and design
ConclusionBRAIN-AF will determine whether oral anticoagulation therapy with rivaroxaban compared with standard of care reduces the risk of stroke, TIA or cognitive decline in patients with non-valvular AF and a low risk of stroke.
Source: Canadian Journal of Cardiology - May 8, 2019 Category: Cardiology Source Type: research

Post-stroke dementia is associated with increased subsequent all-cause mortality: A population-based cohort study
We aimed to determine whether patients with post-stroke dementia (PSD) have increased mortality risk in Taiwan.
Source: Atherosclerosis - March 12, 2019 Category: Cardiology Authors: Tomor Harnod, Cheng-Li Lin, Chung Y. Hsu, Chia-Hung Kao Source Type: research