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Direct oral anticoagulants in the prevention of stroke in breast cancer patients with atrial fibrillation during adjuvant endocrine therapy: A cohort study
Atrial fibrillation (AF) is a frequent comorbidity in malignant patients. Anticancer therapies complicate anticoagulant strategy. We evaluated the safety and efficacy of long-term use of direct oral anticoagulants (DOACs) in breast cancer women.
Source: International Journal of Cardiology - September 11, 2020 Category: Cardiology Authors: Renata Pacholczak-Madej, Stanis ława Bazan-Socha, Lech Zaręba, Anetta Undas, Jerzy Dropiński Source Type: research

Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study.
CONCLUSIONS: In this population-based study, aromatase inhibitors were associated with increased risks of heart failure and cardiovascular mortality compared with tamoxifen. There were also trends toward increased risks, although nonsignificant, of myocardial infarction and ischemic stroke. The increased risk of cardiovascular events associated with aromatase inhibitors should be balanced with their favorable clinical benefits compared with tamoxifen. PMID: 32065766 [PubMed - in process]
Source: Circulation - February 17, 2020 Category: Cardiology Authors: Khosrow-Khavar F, Filion KB, Bouganim N, Suissa S, Azoulay L Tags: Circulation Source Type: research

Sex Differences in Atrial Fibrillation —Update on Risk Assessment, Treatment, and Long-Term Risk
AbstractPurpose of reviewAtrial fibrillation (AF) is a growing health problem worldwide. While the disease plagues both men and women, this arrhythmia does not affect both sexes equally. Women are more likely to have major adverse outcomes such as stroke and its sequela; however, recent data on stroke prevention show improving outcomes. The purpose of this review of the recent literature is to summarize important updates on risk scores and management of patients with AF.Recent findingsIt has been well known that women have a higher risk of strokes than men when untreated or when treated with warfarin. Current risk scores e...
Source: Current Treatment Options in Cardiovascular Medicine - August 27, 2018 Category: Cardiology Source Type: research

Increases In CVD Risk Factors Linked to Worse Survival in Breast Cancer (CME/CE)
(MedPage Today) -- Up to 3x higher risk of acute heart failure and stroke with co-morbid diabetes, CAD, hypertension
Source: MedPage Today Cardiovascular - April 8, 2018 Category: Cardiology Source Type: news

Atrial Fibrillation, Clinical Profile and Adherence to Guidelines
Conclusion: Discordance between guidelines and practice was found regarding prescription of OACs and maintenance of optimal anticoagulation for stroke prevention in our population. Optimal anticoagulation needs to be emphasized on both patients as well as physicians to prevent strokes and achieve better outcomes.Keywords:CHADS2 score,International normalized ratio,Oral Anticoagulants,Valvular heart disease.View:PDF (138.96 KB)Click here to download the PDF file.‹ Breast Cancer and the Heart: Burden on the ChestAssociation between Myocardial Infarction and Dermatoglyphics: A Cross-Sectional Study ›
Source: Journal of Cardiovascular Disease Research - March 8, 2018 Category: Cardiology Authors: yunus Source Type: research

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction
Breast cancer radiotherapy increases the risk of heart failure with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radioresistant, but radiation specifically affects coronary microvascular endothelial cells, with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF. Global cardiac expression of the sodium-iodide symporter (NIS) was induced by cardiotropic gene (adeno-associated virus serotype 9) delivery to 5-w...
Source: AJP: Heart and Circulatory Physiology - August 11, 2017 Category: Cardiology Authors: Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C., Russell, S. J., Redfield, M. M. Tags: RESEARCH ARTICLE Source Type: research

High Intensity Interval Training For Maximizing Health Outcomes
Regular physical activity or exercise training are important actions to improve cardiorespiratory fitness and maintain health throughout life. There is solid evidence that exercise is an effective preventative strategy against at least 25 medical conditions, including cardiovascular disease, stroke, hypertension, colon and breast cancer, and type 2 diabetes. Traditionally, endurance exercise training (ET) to improve health related outcomes has consisted of low- to moderate ET intensity. However, a growing body of evidence suggests that higher exercise intensities may be superior to moderate intensity for maximizing health outcomes.
Source: Progress in Cardiovascular Diseases - April 3, 2017 Category: Cardiology Authors: Trine Karlsen, Inger-Lise Aamot, Mark Haykowsky, Øivind Rognmo Source Type: research

Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts Epidemiology
Conclusions Off-hour admission is associated with increased mortality risk, and the associations varied substantially for different diseases. Specialists, nurses, as well as hospital administrators and health policymakers can take these findings into consideration to improve the quality and continuity of medical services.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Zhou, Y., Li, W., Herath, C., Xia, J., Hu, B., Song, F., Cao, S., Lu, Z. Tags: Epidemiology, Risk Factors, Health Services, Meta Analysis, Mortality/Survival Source Type: research

Subclinical Myocardial Impairment Occurred in Septal and Anterior LV Wall Segments After Anthracycline-Embedded Chemotherapy and did not Worsen During Adjuvant Trastuzumab Treatment in Breast Cancer Patients.
Abstract In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up to 6 months of adjuvant Herceptin(®) therapy. Twenty-seven female breast cancer patients with Her-2/-neu overexpression were studied using conventional echocardiography and 2D speckle tracking. These methods were done before anthracycline-embedded chemotherapy, before adjuvant trastuzumab...
Source: Cardiovascular Toxicology - May 29, 2015 Category: Cardiology Authors: Lange SA, Jung J, Jaeck A, Hitschold T, Ebner B Tags: Cardiovasc Toxicol Source Type: research

Young obese women could reduce their stroke risk
The global campaign to tackle stroke highlights the role of caregivers in supporting people who have suffered a stroke and aims to correct misinformation about the disease, such as the misconception that stroke only happens later in life.  Risk of stroke increases 3.5 times in young women who are overweight or obese and have metabolic disorders. Women are also twice more likely to die from a stroke than breast cancer each year.  Read more  Topics: Cardiovascular Disease Prevention - Risk Assessment and Management, Peripheral Arterial Diseases, Atherosclerosis
Source: ESC News and Press - October 25, 2013 Category: Cardiology Source Type: news

Association of Tamoxifen Use and Reduced Cardiovascular Events Among Asian Females With Breast Cancer.
Conclusions: In Asian female breast cancer patients, tamoxifen use was associated with reduced risks of AMI, ischemic, hemorrhagic stroke and total cardiovascular events. PMID: 24107360 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 9, 2013 Category: Cardiology Authors: Yang TL, Wu TC, Huang CC, Huang PH, Chung CM, Lin SJ, Chen JW, Chan WL, Chiang CH, Leu HB Tags: Circ J Source Type: research

Cardiovascular Care for Women: The 10-Q Report and Beyond
Abstract: According to The National Coalition for Women's Health Research's 10Q Report: Advancing women's heart health through improved research, diagnosis, and treatment published in June 2011, cardiovascular disease (CVD), a term used to describe diseases of the heart or blood vessels, is the leading cause of death for women in the United States, causing more than 420,000 deaths among women annually. Experts estimate that one in two women will die of heart disease or stroke compared with one in 25 women who will die of breast cancer. Despite the fact that more women than men die each year of heart disease and that there...
Source: The American Journal of Cardiology - August 1, 2013 Category: Cardiology Authors: Nanette K. Wenger, Sharonne N. Hayes, Carl J. Pepine, William C. Roberts Tags: Multimedia Activities Source Type: research

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