Filtered By:
Specialty: Biology
Procedure: Anesthesia
This page shows you your search results in order of date.
Order by Relevance | Date
Total 14 results found since Jan 2013.
Systematic underestimation of human hand weight
Curr Biol. 2023 Jul 24;33(14):R758-R759. doi: 10.1016/j.cub.2023.05.041.ABSTRACTAccording to Newton's laws, the weight of a body part is equal to its mass times gravitational acceleration. Our experience of body part weight, however, is constructed by the central nervous system. No sensory receptors directly specify the weight of body parts, and the factors influencing perceived weight remain unknown. The perceived weight of held objects has been linked to sensations of the magnitude of central motor commands sent to the muscles, what Helmholtz called the effort of will and has subsequently been called the sense of effort1...
Source: Current Biology - July 25, 2023 Category: Biology Authors: Elisa R Ferr è Jonathan Joel Denise Cadete Matthew R Longo Source Type: research
Embryonic developmental oxygen preconditions cardiovascular functional response to acute hypoxic exposure and maximal {beta}-adrenergic stimulation of anesthetized juvenile American alligators (Alligator mississippiensis) RESEARCH ARTICLE
Brandt Smith, Janna L. Crossley, Ruth M. Elsey, James W. Hicks, and Dane A. Crossley II
The effects of the embryonic environment on juvenile phenotypes are widely recognized. We investigated the effect of embryonic hypoxia on the cardiovascular phenotype of 4-year-old American alligators (Alligator mississippiensis). We hypothesized that embryonic 10% O2 preconditions cardiac function, decreasing the reduction in cardiac contractility associated with acute 5% O2 exposure in juvenile alligators. Our findings indicate that dobutamine injections caused a 90% increase in systolic pressure in juveniles that were incubated in 2...
Source: Journal of Experimental Biology - November 7, 2019 Category: Biology Authors: Smith, B., Crossley, J. L., Elsey, R. M., Hicks, J. W., Crossley, D. A. Tags: RESEARCH ARTICLE Source Type: research
Embryonic developmental oxygen preconditions cardiovascular function response to acute hypoxic exposure and maximal {beta}-adrenergic stimulation of anesthetized juvenile American alligators (Alligator mississippiensis) RESEARCH ARTICLE
Brandt Smith, Janna L. Crossley, Ruth M. Elsey, James W. Hicks, and Dane A. Crossley II The effects of the embryonic environment on juvenile phenotypes are widely recognized. We investigated the effect of embryonic hypoxia on the cardiovascular phenotype of 4-year-old American alligators (Alligator mississippiensis). We hypothesized that embryonic 10% oxygen preconditions cardiac function, decreasing the reduction in cardiac contractility associated with acute 5% oxygen exposure in juvenile alligators. Our findings indicate that dobutamine injections caused a 90% increase in systolic pressure in juveniles that were incubat...
Source: Journal of Experimental Biology - September 22, 2019 Category: Biology Authors: Smith, B., Crossley, J. L., Elsey, R. M., Hicks, J. W., Crossley, D. A. Tags: RESEARCH ARTICLE Source Type: research
Magnetic resonance imaging (MRI) reveals high cardiac ejection fractions in red-footed tortoises (Chelonoidis carbonarius) SHORT COMMUNICATION
Catherine J. A. Williams, Eva M. Greunz, Steffen Ringgaard, Kasper Hansen, Mads F. Bertelsen, and Tobias Wang
The ejection fraction of the trabeculated cardiac ventricle of reptiles has not previously been measured. Here, we used the gold standard clinical methodology – electrocardiogram-gated flow magnetic resonance imaging (MRI) – to validate stroke volume measurements and end diastolic ventricular blood volume. This produced an estimate of ejection fraction in our study species, the red footed tortoise Chelonoidis carbonarius (n=5), under isoflurane anaesthesia of 88±11%. After reduction of the preva...
Source: Journal of Experimental Biology - September 15, 2019 Category: Biology Authors: Williams, C. J. A., Greunz, E. M., Ringgaard, S., Hansen, K., Bertelsen, M. F., Wang, T. Tags: SHORT COMMUNICATION Source Type: research
Magnetic Resonance Imaging (MRI) reveals high cardiac ejection fractions in red-footed tortoises (Chelonoidis carbonarius) SHORT COMMUNICATION
Catherine J. A. Williams, Eva M. Greunz, Steffen Ringgaard, Kasper Hansen, Mads F. Bertelsen, and Tobias Wang The ejection fraction of the trabeculated cardiac ventricle of reptiles has not previously been measured. Here we use the gold standard clinical methodology – electrocardiogram (ECG) gated flow magnetic resonance imaging (MRI) – to validate stroke volume measurements and end diastolic ventricular blood volumes. This produces an estimate of ejection fraction in the red footed tortoise Chelonoidis carbonaria (n=5) under isoflurane anaesthesia of 88±11%. After elimination of the prevailing right-to-...
Source: Journal of Experimental Biology - August 21, 2019 Category: Biology Authors: Williams, C. J. A., Greunz, E. M., Ringgaard, S., Hansen, K., Bertelsen, M. F., Wang, T. Tags: SHORT COMMUNICATION Source Type: research
NIH scientists identify spasm in women with endometriosis-associated chronic pelvic pain
(NIH/National Institute of Neurological Disorders and Stroke) Pelvic pain associated with endometriosis often becomes chronic and can persist (or recur) following surgical and hormonal interventions. According to results published in Regional Anesthesia& Pain Medicine, treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life. The study was conducted by scientists at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: EurekAlert! - Biology - July 11, 2019 Category: Biology Source Type: news
Development of a Reactive Oxygen Species-Sensitive Nitric Oxide Synthase Inhibitor for the Treatment of Ischemic Stroke.
In this study, the nitrone 5was designed such that its decomposition product is a NOS inhibitor, 6, effectively leading to NOS inhibition specifically at the site of ROS production. The ability of 5to spin-trap radicals and decompose to 6 was observed using EPR and LC-MS/MS. The pro-drug concept was tested in vitro by measuring cell viability and 6 formation in SH-SY5Y cells subjected to oxygen glucose deprivation (OGD). 5 was found to be more efficacious and more potent than PBN, and was able to increase phospho-Akt while reducing nitrotyrosine and cleaved caspase-3 levels. 6 treatment, but not 5, was found to decrease NO...
Source: Free Radical Biology and Medicine - December 21, 2017 Category: Biology Authors: Nash KM, Schiefer IT, Shah ZA Tags: Free Radic Biol Med Source Type: research
Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia Research
In humans, hyperthermic episodes can be triggered by halogenated anesthetics [malignant hyperthermia (MH) susceptibility] and by high temperature [environmental heat stroke (HS)]. Correlation between MH susceptibility and HS is supported by extensive work in mouse models that carry a mutation in ryanodine receptor type-1 (RYR1Y522S/WT) and calsequestrin-1 knockout (CASQ1-null), 2 proteins that control Ca2+ release in skeletal muscle. As overheating episodes in humans have also been described during exertion, here we subjected RYR1Y522S/WT and CASQ1-null mice to an exertional-stress protocol (incremental running on a treadm...
Source: FASEB Journal - August 1, 2017 Category: Biology Authors: Michelucci, A., Paolini, C., Boncompagni, S., Canato, M., Reggiani, C., Protasi, F. Tags: Research Source Type: research
Improved cardiac filling facilitates the postprandial elevation of stroke volume in Python regius RESEARCH ARTICLE
Sanne Enok, Gabriella S. P. C. Leite, Cleo A. C. Leite, Hans Gesser, Michael S. Hedrick, and Tobias Wang
To accommodate the pronounced metabolic response to digestion, pythons increase heart rate and elevate stroke volume, where the latter has been ascribed to a massive and fast cardiac hypertrophy. However, numerous recent studies show that heart mass rarely increases, even upon ingestion of large meals, and we therefore explored the possibility that a rise in mean circulatory filling pressure (MCFP) serves to elevate venous pressure and cardiac filling during digestion. To this end, we measured blood flows and pressures...
Source: Journal of Experimental Biology - October 4, 2016 Category: Biology Authors: Enok, S., Leite, G. S. P. C., Leite, C. A. C., Gesser, H., Hedrick, M. S., Wang, T. Tags: RESEARCH ARTICLE Source Type: research
The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output RESEARCH ARTICLE
Morten Smerup, Mads Damkjaer, Emil Brondum, Ulrik T. Baandrup, Steen Buus Kristiansen, Hans Nygaard, Jonas Funder, Christian Aalkjaer, Cathrine Sauer, Rasmus Buchanan, Mads Frost Bertelsen, Kristine Ostergaard, Carsten Grondahl, Geoffrey Candy, J. Michael Hasenkam, Niels H. Secher, Peter Bie, and Tobias Wang
Giraffes – the tallest extant animals on Earth – are renowned for their high central arterial blood pressure, which is necessary to secure brain perfusion. Arterial pressure may exceed 300 mmHg and has historically been attributed to an exceptionally large heart. Recently, this has been refuted by seve...
Source: Journal of Experimental Biology - February 3, 2016 Category: Biology Authors: Smerup, M., Damkjaer, M., Brondum, E., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Funder, J., Aalkjaer, C., Sauer, C., Buchanan, R., Bertelsen, M. F., Ostergaard, K., Grondahl, C., Candy, G., Hasenkam, J. M., Secher, N. H., Bie, P., Wang, T. Tags: RESEARCH ARTICLE Source Type: research
Neuroprotective effects of dexmedetomidine conditioning strategies: Evidences from an in vitro model of cerebral ischemia
Publication date: Available online 3 December 2015 Source:Life Sciences Author(s): Raquel Rodríguez-González, Tomás Sobrino, Sonia Veiga, Pablo López, Javier Rodríguez-García, Sonia Veiras del Río, Aurora Baluja, José Castillo, Julián Álvarez Aims Dexmedetomidine is a selective agonist of α2-adrenergic receptors with clinical anesthetic and analgesic properties that has also shown neuroprotective effects on several models of brain injury. Because perioperative stroke and brain damage are frequent causes of death in critical care units, we aimed to investigate neuroprotective properties of dexmedetomid...
Source: Life Sciences - December 3, 2015 Category: Biology Source Type: research
