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Specialty: Biomedical Science
Condition: Disability
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Total 121 results found since Jan 2013.
Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage
CONCLUSIONS: This study proves that Gal-3 is involved in neuroinflammation and nerve damage after ICH. Gal-3 expression should not be encouraged early on to prevent neuroinflammation. which provides a new possibility for clinical treatment for ICH patients.PMID:37698533 | DOI:10.18632/aging.205014
Source: Aging - September 12, 2023 Category: Biomedical Science Authors: Tianyu Liang Zheng Zhu Fangxiao Gong Xiaobo Yang Xiaoju Lei Ling Lu Source Type: research
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechani...
Source: Journal of Biomedical Science - September 1, 2023 Category: Biomedical Science Authors: Egor Dzyubenko, Katrin I. Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund and Dirk M. Hermann Tags: Research Source Type: research
Motor network reorganization in stroke patients with dyskinesias during a shoulder-touching task: A fNIRS study
This study aimed to explore the brain activation and network reorganization of the motor cortex (MC) with functional near-infrared spectroscopy (fNIRS). T he MC hemodynamic signals were gained from 22 stroke patients and 14 healthy subjects during a shoulder-touching task with the right hand. The MC activation pattern and network attributes analyzed with the graph theory were compared between the two groups. The results revealed that healthy controls presented dominant activation in the left MC while stroke patients exhibited dominant activation in the bilateral hemispheres MC. The MC networks for the two groups had small-...
Source: Journal of Innovative Optical Health Sciences - June 19, 2023 Category: Biomedical Science Authors: Yizheng Zhang Dan Wang Dongyang Wang Kecheng Yan Li Yi Shuoshu Lin Guangjian Shao Zhiyong Shao Jinyan Sun Aoran Yang Source Type: research
Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity
Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome. The complement C3a receptor (C3aR) is a regulator of inflammation with roles in neurodevelopment, neural plasticity, and neurodegeneration. Using mice lacking C3aR (C3aR–/–) and mice overexpressing C3a in the brain, we uncovered 2 opposing effects of C3aR signaling on functional recovery after ischemic stroke: inhibition in the acute phase and facilitation in the later phase. Peri-infarct astrocyte reactivity w...
Source: Journal of Clinical Investigation - May 15, 2023 Category: Biomedical Science Authors: Anna Stokowska, Markus Aswendt, Daniel Zucha, Stephanie Lohmann, Frederique Wieters, Javier Morán Suarez, Alison L. Atkins, YiXian Li, Maria Miteva, Julia Lewin, Dirk Wiedermann, Michael Diedenhofen, Åsa Torinsson Naluai, Pavel Abaffy, Lukas Valihrach, Source Type: research
Effect of alteplase, benzodiazepines and beta-blocker on post-stroke pneumonia: Exploration of VISTA-Acute
by Thanh G. Phan, Richard Beare, Philip M. Bath, Svitlana Ievlieva, Stella Ho, John Ly, Amanda G. Thrift, Velandai K. Srikanth, Henry Ma, on behalf of the VISTA-Acute Collaborators
BackgroundPost-stroke pneumonia is a frequent complication of stroke and is associated with high mortality. Investigators have described its associations with beta-blocker. However, there has been no evaluation of the role of recombinant tissue plasminogen activator (RTPA). We postulate that RTPA may modify the effect of stroke on pneumonia by reducing stroke disability. We explore this using data from neuroprotection trials in Virtual Internati...
Source: PLoS One - May 1, 2023 Category: Biomedical Science Authors: Thanh G. Phan Source Type: research
Integrative identification of hub genes in development of atrial fibrillation related stroke
ConclusionsHub genesEIF4E3,ZNF595,ZNF700,MATR3,ACKR4,ANXA3,SEPSECS-AS1, andRNF166 have potential as novel biomarkers and therapeutic targets in AF-related stroke. Thehsa_circ_0018657/hsa-miR-198/EIF4E3 axis could play an important role regulating the development of AF-related stroke.
Source: PLoS One - March 23, 2023 Category: Biomedical Science Authors: Kai Huang Source Type: research
Acupuncture for autophagy in animal models of middle cerebral artery occlusion: A systematic review and meta-analysis protocol
DiscussionThe results of this study may help to explain autophagy in acupuncture therapy for ischemic stroke. The limitation of this review is that all included studies will be retrieved from Chinese or English medical databases due to language barriers. RegistrationWe registered in PROSPERO on May 31, 2022. (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=329917) (CRD42022329917).
Source: PLoS One - February 22, 2023 Category: Biomedical Science Authors: Jingxue Yuan Source Type: research
Information, involvement, self-care and support —The needs of caregivers of people with stroke: A grounded theory approach
ConclusionsThere is a need to create a caregiver-centered approach in stroke recovery to ensure limited obstruction to care and reduced uncertainty in stroke recovery. Moreover, through the inclusion of caregivers in stroke recovery, it may be possible to reduce the burden of care to the caregiver and ensure the satisfaction of the healthcare system throughout stroke recovery.
Source: PLoS One - January 31, 2023 Category: Biomedical Science Authors: Elton H. Lobo Source Type: research
Association between Apolipoprotein E genotype and functional outcome in acute ischemic stroke
This study aims to determine whether APOE alleles would affect the functional outcome in acute ischemic stroke (AIS) and whether the relationship between inflammation and stroke-related disability varies according to APOE genotypes. We retrospectively collected the demographic and clinical data of AIS patients within one week of symptom-onset through medical records review. The primary outcome was dependence or death, defined as modified Rankin scale (mRS) score of 2-6, which was assessed at 3 months. Among 1929 enrolled patients, the prevalence of APOE ε4 carriers was 17.73% (342/1929). There were 394 AIS patients (394/1...
Source: Aging - January 14, 2023 Category: Biomedical Science Authors: Xiaoming Rong Jingjuan Chen Dong Pan YuKai Wang Chengguo Zhang Yamei Tang Source Type: research
Impact of anemia on acute ischemic stroke outcomes: A systematic review of the literature
DiscussionThis data suggests that the contemporary thresholds for treating anemia in AIS patients may be inadequate because anemia is strongly associated with poor outcomes (e.g., mRS>2 or mortality) and increased LOS in AIS patients. The current generalized Hb threshold for transfusion (7 g/dL) is also used in AIS patients, however, a more aggressive transfusion parameter should be further explored based on these findings. Further studies are required to confirm these findings and to determine if a more liberal RBCT threshold will result in clinical benefits.
Source: PLoS One - January 5, 2023 Category: Biomedical Science Authors: Ansh Desai Source Type: research
Curcumin ’s mechanism of action against ischemic stroke: A network pharmacology and molecular dynamics study
In conclusion, curcumin affects multiple targets and pathways to inhibit various important pathogenic mechanisms of IS, including oxidative stress, neuronal death, and inflammatory responses. This study offers fresh perspectives on the transformation of curcumin to clinical sett ings and the development of IS therapeutic agents.
Source: PLoS One - January 4, 2023 Category: Biomedical Science Authors: Yangyang Wang Source Type: research
The COVID-19 pandemic effect on the prehospital Madrid stroke code metrics and diagnostic accuracy
by Nicol ás Riera-López, Andrea Gaetano-Gil, José Martínez-Gómez, Nuria Rodríguez-Rodil, Borja M. Fernández-Félix, Jorge Rodríguez-Pardo, Carmen Cuadrado-Hernández, Emmanuel Pelayo Martínez-González, Alicia Villar-Arias, Fátima Gutiérrez-Sánchez, Pablo Busca-Ostolaza, Eduardo Montero-Ruiz, Exu perio Díez-Tejedor, Javier Zamora, Blanca Fuentes-Gimeno, on behalf of the Madrid Stroke Network
BackgroundOnly very few studies have investigated the effect of the COVID-19 pandemic on the pre-hospital stroke code protocol. During the first wave, Spain was one of the most affected countries by the SARS-CoV-2 coronavi...
Source: PLoS One - October 10, 2022 Category: Biomedical Science Authors: Nicol ás Riera-López Source Type: research
Age differences in functioning and contextual factors in community-dwelling stroke survivors: A national cross-sectional survey
ConclusionThese findings provide important information on needs and opportunities in community-based rehabilitation for first-time stroke survivors and reveal that this population has good access to smart devices which can be used in community integration. Moreover, our results support the need for analysis in subgroups of age among the heterogenous group of older individuals in this population.
Source: PLoS One - August 25, 2022 Category: Biomedical Science Authors: Steinunn A. Olafsdottir Source Type: research
Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials
ConclusionThe prognosis of patients with an ischemic stroke or transient ischemic attack is improved with antiplatelets. Cilostazol showed the best risk-benefit characteristics without trade-off with the risk of major bleeding. Improved stroke recurrence with intensified antiplatelet regimens is counterbalanced with higher bleeding risk, and consequently, mortality remains unaffected. Treatment decisions in stroke survivals should integrate the assessment of bleeding risk for better identification of patients with the highest benefit of treatment intensification. Systematic review registrationProspero registration number: ...
Source: PLoS One - August 17, 2022 Category: Biomedical Science Authors: D ániel Tornyos Source Type: research
