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Protective effects of Japanese sake yeast on depressive-like behaviors, oxidative stress and inflammatory parameters in a rat model of global cerebral ischemia/reperfusion
This study evaluates the effects of sake yeast on depressive-like behaviors, oxidative stress and inflammatory parameters in a rat model of global cerebral ischemia/reperfusion. Rats were divided into four groups, including 1) control: without bilateral common carotid artery occlusion (BCCAO) and sake supplement, 2) Ischemia group: rats induced with BCCAO and lack of therapeutic supplement, and 3 and 4) Ischemia + sake groups: rats induced with BCCAO and treated with 25 and 50 mg/kg sake yeast, respectively. Depressive-like behaviors antioxidant enzymes activities were assessed. The induction of stroke increased oxidant st...
Source: Biochemical and Biophysical Research communications - July 7, 2023 Category: Biochemistry Authors: Maryam Vaghari Akbar Hajizadeh Moghaddam Mojtaba Ranjbar Nasrollah Moradikor Source Type: research

Indole-3-carbinol mitigates oxidative stress and inhibits inflammation in rat cerebral ischemia/reperfusion model
The objective of our research was to evaluate the protective properties of indole-3-carbinol (I3C) and its effect on redox status parameters, inflammation, and apoptosis intensity in cerebral ischemia/reperfusion injury (CIRI) in rats. I3C administration to CIRI rats decreased levels of oxidative stress markers and improved aerobic metabolism compared to the animals with CIRI. A decrease in myeloperoxidase activity, proinflammatory cytokines mRNA levels, and expression of redox-sensitive factor Nuclear Factor-κB was observed in rats with CIRI that received I3C. I3C-treated rats with pathology showed decreased caspase acti...
Source: Biochimie - April 29, 2023 Category: Biochemistry Authors: Aleksandra Sergeevna Chichai Tatyana Nikolaevna Popova Evgenii Dmitrievich Kryl'skii Sergei Aleksandrovich Oleinik Grigorii Andreevich Razuvaev Source Type: research

Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB
Appl Biochem Biotechnol. 2022 Jul 15. doi: 10.1007/s12010-022-04060-x. Online ahead of print.ABSTRACTCerebral ischemia and successive reperfusion are the prevailing cause of cerebral stroke. Currently cerebral stroke is considered to be one of the prior causes for high mortality, disability, and morbidity. Cynaropicrin, a sesquiterpene lactone, exhibits various pharmacologic properties and also has an anti-inflammatory property associated with the suppression of the key pro-inflammatory NF-κB pathway. The protective effect of cynaropicrin against oxidative stress and neuroinflammation during CIR injury through the modulat...
Source: Applied Biochemistry and Biotechnology - July 15, 2022 Category: Biochemistry Authors: Tao Jin Bing Leng Source Type: research

Edaravone, a scavenger for multiple reactive oxygen species, reacts with singlet oxygen to yield 2-oxo-3-(phenylhydrazono)-butanoic acid
In this study, we investigated the reactivity of edaravone toward 1O2 and identified its reaction products. Edaravone showed a reactivity toward 1O2 greater than those of uric acid, histidine, and tryptophan, which are believed to be ‍1O2 scavengers in vivo. And we confirmed that 2-oxo-3-(phenylhydrazono)-butanoic acid was formed as an oxidation product. We propose a plausible mechanism for 2-oxo-3-(phenylhydrazono)-butanoic acid production by ‍1O2-induced edaravone oxidation. Since 2-oxo-3-(phenylhydrazono)-butanoic acid has already been identified as a radical-initiated oxidation product, free radical-induced oxidati...
Source: Clinical Biochemistry - June 13, 2022 Category: Biochemistry Authors: Sakiko Amekura Kyouhei Shiozawa Chihiro Kiryu Yorihiro Yamamoto Akio Fujisawa Source Type: research

Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo
CONCLUSIONS: MAG activation triggers Glu uptake into OLs under conditions of Glu overload and induces a robust protective antioxidant response.PMID:34954343 | DOI:10.1016/j.bbadis.2021.166324
Source: Biochimica et Biophysica Acta - December 26, 2021 Category: Biochemistry Authors: Ana L Vivinetto Clara Casta ñares Constanza Garcia-Keller Ana Lis Moyano Cristian Falcon Anabela Palandri Victoria Roz és-Salvador Juan I Rojas Liliana Patrucco Clara Monferran Liliana Cancela Edgardo Cristiano Ronald L Schnaar Pablo H H Lopez Source Type: research

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma
In conclusion, luteolin can improve cognitive decline and enhance neuroprotection in neurodegenerative diseases, TBI, and stroke.
Source: BioFactors - October 24, 2020 Category: Biochemistry Authors: Duraisamy Kempuraj, Ramasamy Thangavel, Deepak D. Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P. Raikwar, Smita A. Zaheer, Shankar S. Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Asgar Zaheer Tags: Review Article Source Type: research

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