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Total 276 results found since Jan 2013.

Effects of Compound Danshen Dripping Pills on Ventricular Remodeling and Cardiac Function after Acute Anterior Wall ST-Segment Elevation Myocardial Infarction (CODE-AAMI): Protocol for a Randomized Placebo-Controlled Trial
This study is designed to evaluate the efficacy and safety of CDDP in improving ventricular remodeling and cardiac function after AAMI on a larger scale.MethodsThis study is a multi-center, randomized, double-blind, placebo-controlled, parallel-group clinical trial. The total of 268 patients with AAMI after primary percutaneous coronary intervention (pPCI) will be randomly assigned 1:1 to the CDDP group (n=134) and control group (n=134) with a follow-up of 48 weeks. Both groups will be treated with standard therapy of ST-segment elevation myocardial infarction (STEMI), with the CDDP group administrating 20 tablets of CDDP ...
Source: Chinese Journal of Integrative Medicine - September 1, 2023 Category: Internal Medicine Source Type: research

Basilar artery diameter as neuroimaging biomarker in Chinese Fabry disease patients
Fabry disease (FD) is an X-linked lysosomal storage disease resulting from mutations of α-galactosidase A gene, and has been emphasized as one of the etiologies of young stroke and leukoencephalopathy. Vertebr...
Source: Orphanet Journal of Rare Diseases - July 10, 2023 Category: Internal Medicine Authors: Yan Lok Tiffany Lam, Bun Sheng, Hoi Ming Kwok, Ellen Lok Man Yu and Ka Fai Johnny Ma Tags: Research Source Type: research

Clinical characteristics, risk factors, and prognostic analyses of coronary small vessel disease: a retrospective cohort study of 986 patients
CONCLUSION: Compared to non-CSVD, CSVD was associated with more complex lesions, had worse revascularization efficacy, and a poorer prognosis.PMID:37259582 | DOI:10.1080/00325481.2023.2221110
Source: Postgraduate Medicine - June 1, 2023 Category: Internal Medicine Authors: Yue Chen Xiao Cui Liujun Jiang Xiaolei Xu Chaoyang Huang Qiwen Wang Source Type: research

Association of beta-2-microglobulin, cystatin C and lipocalin-2 with stroke risk in the general Chinese population
CONCLUSION: Elevated serum B2M, cystatin C and LCN-2 levels are associated with stroke risk. They may be novel biomarkers for clinicians to assess stroke risk.Key messagesSerum beta-2-microglobulin, cystatin C and lipocalin-2 levels are significantly associated with stroke risk.Beta-2-microglobulin, cystatin C and lipocalin-2 may serve as useful biomarkers for stroke risk stratification in the general population.PMID:37155257 | PMC:PMC10167872 | DOI:10.1080/07853890.2023.2203516
Source: Annals of Medicine - May 8, 2023 Category: Internal Medicine Authors: Juanying Zhen Shuyun Liu Ryan Yan Lam Kam Guoru Zhao Hao Peng Jianguo Liang Aimin Xu Chao Li Lijie Ren Jun Wu Bernard Man Yung Cheung Source Type: research

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets
AbstractThe prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia can lead to a range of diseases such as atherosclerosis, stroke, coronary heart disease, myocardial infarction, diabetes, and kidney failure, etc. High circulating low-density lipoprotein cholesterol (LDL-C) is one of the causes of hyperlipidemia. LDL-C in the blood binds to LDL receptor (LDLR) and regulates cholesterol homeostasis through endocytosis. In contrast, proprotein convertase subtilisin/kexin ...
Source: Chinese Journal of Integrative Medicine - March 13, 2023 Category: Internal Medicine Source Type: research

The rare manifestations in tuberculous meningoencephalitis: a review of available literature
Conclusion: Understanding and timely improvement of corresponding examinations and targeted treatment will help improve the prognosis of patients.PMID:36598144 | DOI:10.1080/07853890.2022.2164348
Source: Annals of Medicine - January 4, 2023 Category: Internal Medicine Authors: Rong Li He Yun Liu Quanhui Tan Lan Wang Source Type: research

Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine
AbstractCerebral small vessel disease (CSVD) is a senile brain lesion caused by the abnormal structure and function of arterioles, venules and capillaries in the aging brain. The etiology of CSVD is complex, and disease is often asymptomatic in its early stages. However, as CSVD develops, brain disorders may occur, such as stroke, cognitive dysfunction, dyskinesia and mood disorders, and heart, kidney, eye and systemic disorders. As the population continues to age, the burden of CSVD is increasing. Moreover, there is an urgent need for better screening methods and diagnostic markers for CSVD, in addition to preventive and ...
Source: Chinese Journal of Integrative Medicine - December 17, 2022 Category: Internal Medicine Source Type: research

Acupuncture improves the residual urine volume of bladder of middle age patients with urinary retention post-stroke: A protocol for systematic review and meta analysis
Conclusion: The residual urine volume of bladder will be the primary outcome measure, whereas the Clinical efficiency will be the secondary outcomes. Side effects and adverse events will be included as safety evaluations. To ensure the quality of the systematic evaluation, study selection, data extraction, and quality assessment will be independently performed by two authors, whereas a third author will resolve any disagreement.
Source: Medicine - November 25, 2022 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research