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Total 3346 results found since Jan 2013.

Effectiveness and Safety of Autologous Bone Marrow Stromal Cells Transplantation After Ischemic Stroke: A Meta-Analysis.
CONCLUSIONS Although BM-MNCs/MSCs transplantation might generate some benefits in lowering the grade of impairment caused by ischemic stroke, large RCTs are required to further confirm the effectiveness of BM-MSCs/MNCs-based cell therapy and to optimize the conditions require for best therapeutic effects. PMID: 26215395 [PubMed - in process]
Source: Medical Science Monitor - August 1, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Diagnostic TCD for intracranial stenosis in acute stroke patients: experience from a tertiary care stroke center in Karachi, Pakistan
Conclusions: This study indicates the poor sensitivity of TCD to be a reliable screening tool for the presence of ICAD in the South Asian population in a real life clinical setting.
Source: BMC Research Notes - August 11, 2015 Category: Research Authors: Ayeesha KamalHasan RehmanNasir MustafaBilal AhmedMohammad JanFaisal WadivallaSyed Kamran Source Type: research

Robot-Assisted Reach Training for Improving Upper Extremity Function of Chronic Stroke.
Abstract Stroke, as a major risk factor for chronic impairment of upper limb function, can severely restrict the activities of daily living. Recently, robotic devices have been used to enhance the functional upper extremity movement of stroke patients. The purpose of the current study was to assess whether a robot-assisted reach training program using a whole arm manipulator (WAM) could improve upper extremity kinematic performance and functional movement for chronic stroke patients. Using a single-group design, this study followed 10 people with chronic stroke (6 men, 61.5 years; Mini-Mental State Examination sco...
Source: The Tohoku Journal of Experimental Medicine - October 17, 2015 Category: Research Authors: Cho KH, Song WK Tags: Tohoku J Exp Med Source Type: research

Heat shock protein 90 inhibition by 17-Dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke.
Authors: Qi J, Liu Y, Yang P, Chen T, Liu XZ, Yin Y, Zhang J, Wang F Abstract Metalloproteinase (MMP)9 plays a pivotal role in ischemic stroke induced blood brain barrier (BBB) disruption. Correlation between HSP90 and MMP9 in several diseases prompted us to evaluate the efficacy of HSP90 inhibition as a novel approach to protect BBB integrity in ischemic stroke. ELISA was used to detect HSP90α and MMP9 in serum samples of stroke patients, which showed that HSP90α significantly correlated with MMP9 among 63 serum samples of stroke patients. Male C57/BL6 mice were pretreated with 17-Dimethylaminoethylamino-17-deme...
Source: American Journal of Translational Research - December 26, 2015 Category: Research Tags: Am J Transl Res Source Type: research

Unresolved or Contradictory Issues About Management of Patients With Patent Foramen Ovale and Previous Cryptogenic Stroke: Additional Randomized Controlled Trials Are Eagerly Awaited.
Abstract Stating a well-codified and widely accepted therapeutic conduct for patients with patent foramen ovale (PFO) and previous cryptogenic stroke is made difficult and somewhat controversial by several issues remained unresolved so far. In this short review, some aspects of the possible role played by the PFO in the pathogenesis of cryptogenic stroke are succinctly analyzed. First, some aspects of cardiovascular anatomy of the human fetus and the adult are outlined. Subsequently, the three randomized controlled trials (RCTs) that have been accomplished so far to compare the implant of a transeptal occluding de...
Source: Clin Med Res - April 19, 2016 Category: Research Authors: De Vecchis R, Baldi C Tags: J Clin Med Res Source Type: research

Total atrial conduction time to predict occult atrial fibrillation after cryptogenic stroke.
CONCLUSION: Our data suggest that measurement of TACT could help to predict future AF detection in patients with cryptogenic stroke. The clinical importance of prolonged rhythm monitoring or indication of direct anticoagulation therapy after cryptogenic stroke based on TACT should be further investigated. PMID: 27541997 [PubMed - as supplied by publisher]
Source: Clin Med Res - August 18, 2016 Category: Research Authors: Müller P, Ivanov V, Kara K, Klein-Wiele O, Forkmann M, Piorkowski C, Blockhaus C, Dimitroulis D, Afzal S, Shin DI, Kelm M, Makimoto H, Mügge A Tags: Clin Res Cardiol Source Type: research

Relationship Between Carotid Stenosis and Infarct Volume in Ischemic Stroke Patients.
CONCLUSIONS Our findings indicate that the percentage of carotid artery stenosis could be useful in predicting the infarct volume of the stroke. PMID: 27984560 [PubMed - in process]
Source: Medical Science Monitor - December 18, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.
CONCLUSIONS Inhibition of miR-155 may play protective roles in ischemic stroke by phosphorylating S6K through the Rheb/mTOR pathway. PMID: 28025572 [PubMed - in process]
Source: Medical Science Monitor - December 28, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis.
In this study, we report that phosphorylation of HDAC4 was remarkably upregulated after stroke and blockade of HDAC4 phosphorylation with GÖ6976 repressed stroke-induced angiogenesis. Phosphorylation of HDAC4 was also increased in endothelial cells hypoxia model and suppression of HDAC4 phosphorylation inhibited the tube formation and migration of endothelial cells in vitro. Furthermore, in addition to the inhibition of angiogenesis, blockade of HDAC4 phosphorylation suppressed the expression of genes downstream of HIF-VEGF signaling in vitro and in vivo. These data indicate that phosphorylated HDAC4 may serve as an impor...
Source: Biomed Res - January 28, 2017 Category: Research Authors: Liu J, Zhou X, Li Q, Zhou SM, Hu B, Hu GW, Niu X, Guo SC, Wang Y, Deng ZF Tags: Biomed Res Int Source Type: research

Different impairment of immune and inflammation functions in short and long-term after ischemic stroke.
This study aims to explore the difference of global gene expression profiles and impairment of biological functions between short-term and long-term after stroke onset. We compared three short-term (3 h, 5 h and 24 h) and a long-term (6-month) gene expression levels by a multi-platform microarray data integration method. RankProd was used to calculate the differentially expressed genes between stroke patients and controls. DAVID Bioinformatics Resources was utilized to determine affected biological functions. Consensus cluster and hierarchical cluster methods were employed to compare the gene expression patterns of the com...
Source: American Journal of Translational Research - March 27, 2017 Category: Research Tags: Am J Transl Res Source Type: research

TRPC Channels and Stroke.
Authors: Huang J Abstract TRPC channels play important roles in neuronal death/survival in ischemic stroke, vasospasm in hemorrhagic stroke, thrombin-induced astrocyte pathological changes, and also in the initiation of stroke by affecting blood pressure and atherogenesis. TRPCs' unique channel characters and downstream pathways make them possible new targets for stroke therapy. TRPC proteins have different functions in different cell types. Considering TRPCs' extensive distribution in various tissues and cell types, drugs targeting them could induce more complicated effects. More specific agonists/antagonists and ...
Source: Advances in Experimental Medicine and Biology - May 17, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Long-term trends and predictors of smoking behaviors among men following first-ever ischemic stroke
SummaryContinued smoking following stroke is associated with adverse outcomes including increased risk of mortality and secondary stroke. The aim of this study was to examine the long-term trends in smoking behaviors and factors associated with smoking relapse among men who survived their first-ever stroke. Data collection for this longitudinal study was conducted at baseline through face-to-face interviews and follow-up was completed every 3 months via telephone, beginning in 2010 and continuing through 2014. Cox proportional hazard regression models were used to identify predictors of smoking relapse behavior. At baselin...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - June 1, 2017 Category: Research Source Type: research

Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy.
CONCLUSIONS Overall, our results suggest the possibility of language-related cortical plasticity following stroke-induced aphasia with no specific effect from CIAT training. PMID: 28719572 [PubMed - in process]
Source: Medical Science Monitor - July 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Neuroprotective Functions Through Inhibition of ER Stress by Taurine or Taurine Combination Treatments in a Rat Stroke Model.
Authors: Prentice H, Gharibani PM, Ma Z, Alexandrescu A, Genova R, Chen PC, Modi J, Menzie J, Pan C, Tao R, Wu JY Abstract Taurine, as a free amino acid, is found at high levels in many tissues including brain, heart and skeletal muscle and is known to demonstrate neuroprotective effects in a range of disease conditions including stroke and neurodegenerative disease. Using in vitro culture systems we have demonstrated that taurine can elicit protection against endoplasmic reticulum stress (ER stress) from glutamate excitotoxicity or from excessive reactive oxygen species in PC12 cells or rat neuronal cultures. In o...
Source: Advances in Experimental Medicine and Biology - August 31, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Is the 1298A & gt;C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis
In conclusion, the 1298A>C polymorphism in theMTHFR gene is not a risk factor for ischaemic stroke in paediatric patients.
Source: Clinical and Experimental Medicine - February 2, 2018 Category: Research Source Type: research