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Total 299 results found since Jan 2013.

Subconcussive blows and soccer: what’s the headache?
As the fall sports ramps up, teen athletes across the country are donning shin guards and cleats, prepping to return to their beloved sport—soccer. A handful, however, are foregoing the ritual. One child sitting on the sidelines is the 13-year old daughter of Ken Reed, sports policy director of the League of Fans. Reed and his wife decided the risk of short- and long-term brain damage from subconcussive blows to the head outweighed the benefits of the sport. They pulled their daughter from the field, a decision Reed shared on this recent Huffington Post blog. Thriving checked with William Meehan, MD, director of Boston C...
Source: Thrive, Children's Hospital Boston - September 25, 2013 Category: Pediatrics Authors: Lisa Fratt Tags: All posts Concussions Orthopedics Sports & exercise athlete and concussion Bill Meehan soccer injuries Sports Concussion Clinic Source Type: news

Stroke in paediatric pneumococcal meningitis: a cross-sectional population-based study
Before routine infant pneumococcal immunisation and improved access to neuroimaging, around 25% of children with pneumococcal meningitis (PM) suffered ischaemic stroke (IS).1 2 In a population-based retrospective audit (UHS ZAUD2053), we investigated the postimmunisation prevalence of stroke/cerebrovascular disease (CVD), and compared features of children with and without IS/CVD. We included all cases of PM in children <18 years old with a Wessex postcode admitted to our tertiary centre, University Hospital Southampton (UHS) and the eight hospitals in our referral catchment area of Hampshire and Dorset (2001 childh...
Source: Archives of Disease in Childhood - July 11, 2013 Category: Pediatrics Authors: Pryde, K., Walker, W. T., Hollingsworth, C., Haywood, P., Baird, J., Hussey, M., Freeman, A., Gawne-Cain, M., Harms, B., Kirkham, F. J., Faust, S. N. Tags: PostScript Source Type: research

Current management of post-varicella stroke in children: A literature review.
Abstract Among infectious factors, varicella-zoster virus (VZV) is a leading cause of central nervous system vasculopathy and stroke in childhood. Not only have viral markers been detected in the cerebrospinal fluid of affected patients, but also direct evidence of viral particles in the wall of cerebral arteries has been demonstrated in rare pathological specimens. This certainly reflects a localized infectious process likely associated with variable indirect inflammatory responses. Yet the usefulness in this setting of a lumbar puncture as well as of subsequent targeted antiviral and/or anti-inflammatory therapi...
Source: Archives de Pediatrie - July 6, 2013 Category: Pediatrics Authors: Monteventi O, Chabrier S, Fluss J Tags: Arch Pediatr Source Type: research

Evaluation of perinatal arterial ischemic stroke using non-invasive arterial spin labeling perfusion MR imaging.
Conclusion:ASL perfusion MR imaging is able to reliably detect hypo- and hyperperfusion in PAIS patients and can be used to monitor the evolution of perfusion after an ischemic event.Pediatric Research (2013); doi:10.1038/pr.2013.111. PMID: 23797533 [PubMed - as supplied by publisher]
Source: Pediatric Research - June 24, 2013 Category: Pediatrics Authors: De Vis JB, Petersen ET, Kersbergen KJ, Alderliesten T, de Vries LS, van Bel F, Groenendaal F, Lemmers PM, Hendrikse J, Benders MJ Tags: Pediatr Res Source Type: research

Development of psychological and intellectual performance in transplanted sickle cell disease patients: A prospective study from pretransplant period to 5years after HSCT.
CONCLUSION: At the end of follow-up, the patients improved their physical and psychological well-being. This allowed them to build projects for the future and to manifest the desire of becoming an adult. Bone marrow transplantation in this cohort of children with SCD and severe cerebral vasculopathy is associated with improved performance as measured by the Wechsler scale. PMID: 23769628 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - June 11, 2013 Category: Pediatrics Authors: Bockenmeyer J, Chamboredon E, Missud F, Benkerrou M, Holvoët L, Ithier G, Lescoeur B, Yakouben K, Ouachée-Chardin M, Rohrlich PS, Duval M, Baruchel A, Dalle JH Tags: Arch Pediatr Source Type: research

Pain in young people aged 13 to 17 years with cerebral palsy: cross-sectional, multicentre European study
Conclusions Pain in young people with CP is highly prevalent. Because pain causes immediate distress and is associated with lower subjective well-being and reduced participation, clinicians should routinely assess pain. Clinical interventions to reduce pain should be implemented and evaluated. The efficacy of medical and therapeutic interventions causing pain should be re-examined to establish if their benefit justifies the pain and fear of pain that accompany them.
Source: Archives of Disease in Childhood - May 9, 2013 Category: Pediatrics Authors: Parkinson, K. N., Dickinson, H. O., Arnaud, C., Lyons, A., Colver, A., on behalf of the SPARCLE group, Beckung, Parkes, Fauconnier, Lyons, Michelsen, Marcelli, Arnaud, Thyen, Rapp Tags: Cerebral palsy, Open access, Headache (including migraine), Pain (neurology), Stroke, Child health, Physiotherapy, Physiotherapy Original article Source Type: research

Investigation into the effect of prasugrel versus clopidogrel on platelet thromboelastography (TEG) analysis in paediatric patients on Ventricular Assistance Devices (VAD)
Conclusions The response seen in our patients to prasugrel is similar to studies conducted in adults where prasugrel achieves a greater ADP inhibition than clopidogrel.2 Additionally the time take to achieve effective ADP inhibition was faster. One of the possible causes of this is likely to be due to the different expression of metabolising enzymes in individual patients as both drugs are metabolised in vivo to form their active substrates.3 As prasugrel gives more effective ADP inhibition than clopidogrel, the risk of bleeding events will also be higher. This has been observed in adult clinical trials.2 The intra- and in...
Source: Archives of Disease in Childhood - May 9, 2013 Category: Pediatrics Authors: Morris, S., Cassidy, J. Tags: Drugs: cardiovascular system, Stroke Abstracts from the Poster and Oral presentations from the 18th Neonatal and Paediatric Pharmacists Group (NPPG) Annual Conference held at the Liverpool Marriott Hotel from 9-11 November 2012 Source Type: research

Structural Neuroplastic Change After Constraint-Induced Movement Therapy in Children With Cerebral Palsy
Research from the present laboratory with adult stroke patients showed that structural neuroplastic changes are correlated with clinical improvements due to constraint-induced movement (CI) therapy. This pilot study evaluated whether comparable changes occur in children receiving CI therapy. Ten children (6 boys) with congenital hemiparesis (mean age: 3 years, 3 months) underwent MRI scans 3 weeks before, immediately before, and immediately after receiving 3 weeks of CI therapy. Longitudinal voxel-based morphometry was performed on MRI scans to determine gray matter change. In addition, the Pediatric Motor Activity Log-Rev...
Source: PEDIATRICS - May 1, 2013 Category: Pediatrics Authors: Sterling, C., Taub, E., Davis, D., Rickards, T., Gauthier, L. V., Griffin, A., Uswatte, G. Tags: Case Report Source Type: research

The Teen Years Put the 'Stroke' in 'Stroke Belt' (CME/CE)
(MedPage Today) -- Living in the "stroke belt" during adolescence may predispose individuals to an increased risk of stroke, even if they move to another region of the country, data from a large cohort study suggested.
Source: MedPage Today Pediatrics - April 26, 2013 Category: Pediatrics Source Type: news

Low CD8 T‐cells in neonates and infants prior to surgery and healthcare‐associated infections: a prospective observational study.
Cytotoxic T‐lymphocytes (CD8 T‐cells) are a powerful component of the adaptive immune system. They are involved in the eradication of intracellular infections, tumours, and contribute to rejection of organ transplants; and autoimmunity [1]. Several studies in humans and animals have demonstrated that altered host defence mechanisms after major surgery or trauma are an important risk in the development of postsurgical healthcare‐associated infections [2‐4]. These and other studies have demonstrated decreased counts and/or response of T‐lymphocytes to mitogenic activation in patients following general surgery, blun...
Source: Pediatrics International - April 1, 2013 Category: Pediatrics Authors: Stefan Grosek, Ziva Petrin, Andreja Natasa Kopitar, Tanja Gmeiner Stopar, Mirjana Petreska, Janez Primozic, Janez Erzen, Jan Grosek, Alojz Ihan Tags: Clinical Investigations Source Type: research

Developmental Function in Toddlers With Sickle Cell Anemia
This study adds the observation that poorer neurocognitive and behavioral function is associated with older age in infants and toddlers with sickle cell anemia, much earlier than previously expected. (Read the full article)
Source: PEDIATRICS - February 1, 2013 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Hospitalisation with otitis media in early childhood and cognitive function in young adult life: a prevalence study among Danish conscripts
Conclusions: Overall, we found that hospitalisation with OM in early childhood was associated with a slightly lower cognitive function in early adulthood. Hospitalisation for OM did not seem to influence the prevalence of GSCE when level of BPP was taken into account.
Source: BMC Pediatrics - Latest articles - January 15, 2013 Category: Pediatrics Authors: Marie MortensenRikke NielsenNiels FiskerMette Nørgaard Source Type: research

Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke
Conclusion: Arteriopathy and coagulation activation are highly prevalent in the acute period of childhood AIS. Although recurrent AIS and intracranial hemorrhage were infrequent in our cohort, one-half of children experienced a poor neurologic outcome at 1 year, the risk of which was increased by acute arteriopathy. Substantiation of these findings in multi-institutional cohort studies is warranted, toward risk stratification in childhood-onset AIS.
Source: The Journal of Pediatrics - December 20, 2012 Category: Pediatrics Authors: Neil A. Goldenberg, Sarah Jenkins, Jessica Jack, Jennifer Armstrong-Wells, Laura Z. Fenton, Nicholas V. Stence, Joyce Oleszek, Richard Boada, Greta N. Wilkening, Charles Wilkinson, Jennifer B. Soep, Shelley D. Miyamoto, Lalit Bajaj, Peter M. Mourani, Mari Tags: Original Articles Source Type: research

Plasma topiramate concentrations resulting from doses associated with neuroprotection against white matter injury and stroke in two strains of rat pups.
ConclusionsTopiramate concentrations associated with neuroprotective doses were determined. Body size and strain were significant covariates on CL/F and V/F. Results provide targets for future neuroprotection studies.Pediatric Research (2012); doi:10.1038/pr.2012.194. PMID: 23254278 [PubMed - as supplied by publisher]
Source: Pediatric Research - December 19, 2012 Category: Pediatrics Authors: Clark A, Mondick JT, Cloyd J, Zuppa AF, Raol YH, Clancy R Tags: Pediatr Res Source Type: research