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Specialty: Pathology

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Total 1464 results found since Jan 2013.

Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-κB signaling pathway
Publication date: Available online 28 October 2018Source: PathophysiologyAuthor(s): Solomon Umukoro, Ejiroghene E. Oghwere, Benneth Ben-Azu, Olatunde Owoeye, Abayomi M. Ajayi, Osarume Omorogbe, Olajuwon OkubenaAbstractThe effects of Jobelyn® (JB) on neurological deficits and biochemical alterations associated with ischemic stroke induced by bilateral common carotid artery occlusion (BCCAO) in rats were investigated in this study. Male Wistar rats were divided into five groups (n = 8): group 1 served as Sham control; group 2, which served as negative control received normal saline while groups 3-5 were given JB (25, 50...
Source: Pathophysiology - October 29, 2018 Category: Pathology Source Type: research

Features of Childhood Arterial Ischemic Stroke in China.
CONCLUSION: Infection was an important risk factor for children with AIS in China. Infection and thrombophilia risk factors were more likely to occur in isolation. The stroke lesions commonly occurred in the basal ganglia region. PMID: 30890011 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - March 22, 2019 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Oxidative stress and stroke: a review of upstream and downstream antioxidant therapeutic options
AbstractThe stroke is a cerebrovascular disorder and is the cause of a second mortality and long-lasting harm worldwide. It is classified into two types: hemorrhagic and ischemic stroke. Globally, 13% of cases of stroke are hemorrhagic, while the remaining 87% are ischemic. In this paper, we discuss the consideration of factors which possibly affect the effectiveness of antioxidant protection under oxygen deprivation, as well as oxidative stress. Such aspects as compartmentalization of reactive oxygen species (ROS)/reactive nitrogen species (RNS) formation and antioxidant localization, synthesis and transport of antioxidan...
Source: Comparative Clinical Pathology - April 8, 2019 Category: Pathology Source Type: research

The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression.
Abstract Ischemic stroke is the main cause of disability and mortality worldwide. Apoptosis and inflammation have an important role in ischemic brain injury. Mesenchymal stem cells (MSCs) have protective effects on stroke treatment due to anti-inflammatory properties. The inhibition of the C-Jun N-terminal kinase (JNK) pathway may be one of the molecular mechanisms of the neuroprotective effect of MSCs in ischemic brain injury. Twenty-eight male Wistar rats were divided randomly into 3 groups. Except the sham group, others subjected to transient middle cerebral artery occlusion (tMCAO). Bone marrow MSCs or saline ...
Source: Pathology, Research and Practice - June 26, 2019 Category: Pathology Authors: Vahidinia Z, Azami Tameh A, Nejati M, Beyer C, Talaei SA, Etehadi Moghadam S, Atlasi MA Tags: Pathol Res Pract Source Type: research

Deaths related to stroke and cerebrovascular disease
Cerebrovascular disease is a common cause of death and the general histopathologist will often be responsible for the post mortem examination of stroke-related death. The pathological findings vary depending on the type of stroke, its location and aetiology. The underlying pathology is variable and includes atherosclerosis, cardiogenic embolism and small vessel disease alongside many rarer causes. The adequate post mortem examination of stroke is essential to usefully inform clinical teams, coronial services and relatives and requires proper preparation, familiarity with the range of underlying pathological processes, care...
Source: Diagnostic Histopathology - August 12, 2019 Category: Pathology Authors: Kieren Simon James Allinson Tags: Mini-symposium: nephrourology Source Type: research

Correlation between focal lesion sites and language deficits in the acute phase of post-stroke aphasia
CONCLUSIONS: Our study suggests that focal lesion sites could lead to different language function impairments in the acute phase of post-stroke aphasia, which adds to our understanding of speech pathology and provides a direction for future research and treatment.PMID:35359146 | DOI:10.5114/fn.2022.114343
Source: Folia Neuropathologica - April 1, 2022 Category: Pathology Authors: Qing-Qing Liu Wei-Bo Li Yue-Wen Song Zhen-Biao Zhao Yan-Ning Yan Yu-Hui Yang Pei-Yuan Lv Yu Yin Source Type: research