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Specialty: Neurology
Therapy: Thrombolytic Therapy

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Total 551 results found since Jan 2013.

Prediction-Driven Decision Support for Patients With Mild Stroke: A Model Based on Machine Learning Algorithms
Conclusions: DAMS and R-DAMS, as prediction-driven decision support tools, were designed to aid clinical decision-making for mild stroke patients in emergency contexts. In addition, even within a narrow range of baseline scores, NIHSS on admission is the strongest feature that contributed to the prediction.
Source: Frontiers in Neurology - December 23, 2021 Category: Neurology Source Type: research

Pre- and in-hospital delays in the use of thrombolytic therapy for patients with acute ischemic stroke in rural and urban Egypt
ConclusionThe limited availability of stroke-ready hospitals in rural Egypt leads to delays in stroke management, with subsequent treatment inequality of rural patients with acute stroke.
Source: Frontiers in Neurology - January 20, 2023 Category: Neurology Source Type: research

Comparing 5G mobile stroke unit and emergency medical service in patients acute ischemic stroke eligible for t ‐PA treatment: A prospective, single‐center clinical trial in Ya'an, China
ConclusionsOur findings indicate that 5G MSU care significantly reduces the time from symptom onset to stroke diagnosis and intravenous thrombolysis in patients with AIS, resulting in improved functional outcomes compared to EMS care. As China continues its deployment of 5G technology and other digital infrastructures, the adoption of 5G MSU care on a broader scale may eventually supplant traditional stroke treatment approaches.
Source: Brain and Behavior - August 26, 2023 Category: Neurology Authors: Bo Zheng, Yan Li, Gangfeng Gu, Jian Yang, Junyao Jiang, Zhao Chen, Yang Fan, Sheng Wang, Han Pei, Jian Wang Tags: ORIGINAL ARTICLE Source Type: research

Early Access to a Neurologist Reduces the Rate of Missed Diagnosis in Young Strokes
Conclusions: Young adults with ischemic stroke seen at hospitals with a neurology residency had a lower missed diagnosis rate. The presence of an EM resident or a neurology teaching program was associated with a greater use of acute stroke therapies. These results support initiatives to triage young adults with suspected acute stroke to hospitals with access to neurologic expertise in the emergency department.
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2013 Category: Neurology Authors: Wazim Mohamed, Pratik Bhattacharya, Seemant Chaturvedi Tags: Original Articles Source Type: research

Perspectives in neonatal and childhood arterial ischemic stroke.
Authors: Fluss J, Dinomais M, Kossotoroff M, Vuillerot C, Darteyre S, Chabrier S Abstract INTRODUCTION: Over the last decade considerable advances have been made in the identification, understanding and management of pediatric arterial ischemic stroke. Such increasing knowledge has also brought new perspectives and interrogations in the current acute and rehabilitative care of these patients. AREAS COVERED: In developed countries, focal cerebral arteriopathy is one of the most common causes of arterial ischemic stroke in childhood and imaging features are well characterized. However, there are ongoing debates regar...
Source: Expert Review of Neurotherapeutics - October 1, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke
Abstract Objective:Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of the blood brain barrier is a central feature to HT pathogenesis, and leukocytes may contribute to this process. We sought to determine whether ischemic strokes that develop HT have differences in RNA expression in blood within 3 hours of stroke onset prior to treatment with thrombolytic therapy. Methods:Stroke patient blood samples were obtained prior to treatment with thrombolysis, and leukocyte RNA assessed by microarray analysis. Strokes that developed HT (n=11) were ...
Source: Annals of Neurology - March 7, 2013 Category: Neurology Authors: Glen C Jickling, Bradley P Ander, Boryana Stamova, Xinhua Zhan, Dazhi Liu, Lena Rothstein BSc, Piero Verro, Jane Khoury, Edward C Jauch, Arthur Pancioli, Joseph P Broderick, Frank R Sharp Tags: Research Article Source Type: research

Measuring Quality Improvement in Acute Ischemic Stroke Care: Interrupted Time Series Analysis of Door-to-Needle Time
Background: In patients with acute ischemic stroke, early treatment with recombinant tissue plasminogen activator (rtPA) improves functional outcome by effectively reducing disability and dependency. Timely thrombolysis, within 1 h, is a vital aspect of acute stroke treatment, and is reflected in the widely used performance indicator ‘door-to-needle time' (DNT). DNT measures the time from the moment the patient enters the emergency department until he/she receives intravenous rtPA. The purpose of the study was to measure quality improvement from the first implementation of thrombolysis in stroke patients in a university ...
Source: Cerebrovascular Diseases Extra - November 7, 2014 Category: Neurology Source Type: research

An Executable Graphical Model for In Silico Prototyping of Processes for Acute Stroke Care (P1.019)
CONCLUSIONS: In silico care process prototyping permits evaluation of proposed innovations in simulated settings. 1. Grotta JC. tPA for stroke: important progress in achieving faster treatment. JAMA. 2014 Apr 23-30;311(16):1615-7. 2. Ford AL et al. Reducing door-to-needle times using Toyota's lean manufacturing principles and value stream analysis. Stroke. 2012 Dec;43(12):3395-8. 3. Meretoja A et al. Reducing in-hospital delay to 20 minutes in stroke thrombolysis. Neurology. 2012 Jul 24;79(4):306-13. Study Supported by:Genentech, Inc.Disclosure: Dr. Norris has received personal compensation for activities with Genentech. D...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Norris, D., Levy, D. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

Influence of previous physical activity on the outcome of patients treated by thrombolytic therapy for stroke
Abstract Physical activity prevents stroke and is associated with less severe strokes. The neuroprotective effect in patients treated with intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA), remains uncertain. We aimed at evaluating the relationship between previous physical activity and outcomes in stroke patients treated with i.v. rt-PA. OPHELIE-SPORT was a prospective observational multicenter study conducted in French and Japanese stroke patients treated with i.v. rt-PA. We evaluated the presence, weekly duration (<2, 2–5, >5 h) and intensity (light, moderate, heavy) of previous leisu...
Source: Journal of Neurology - August 14, 2015 Category: Neurology Source Type: research

Stroke Code Simulation Lab; Save Time Save Brain! (P2.375)
CONCLUSIONS: The stroke code simulation lab met its objectives of improving the neurology residents’ knowledge and experience managing stroke codes. It was perceived as a valuable exercise. Further data will determine if the stroke code simulation lab improves patient care.Disclosure: Dr. Mao has nothing to disclose. Dr. Zidan has nothing to disclose. Dr. Afzal has nothing to disclose. Dr. Cherukuri has nothing to disclose. Dr. Qadeer has nothing to disclose. Dr. Bradshaw has received research support from Cytokinetcs.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Mao, Y., Zidan, A., Afzal, U., Cherukuri, R., Qadeer, U., Bradshaw, D. Tags: Research Methodology and Education: Patient Safety and Quality Source Type: research

Multidisciplinary In Situ Mock Stroke Codes Improve Thrombolytic Delivery by Decreasing Door To Needle Times in a Comprehensive Stroke Center. (P6.086)
Conclusions: Door to needle time is reduced as a result of MSCs. MSCs should be routinely performed at CSCs to improve door to needle time and patient outcomes.Disclosure: Dr. Burshtein has nothing to disclose. Dr. Kapoor has nothing to disclose. Dr. Sorrentino has nothing to disclose. Dr. Michael has nothing to disclose. Dr. Carrazco has nothing to disclose. Dr. Wright has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Burshtein, R., Kapoor, A., Sorrentino, C., Michael, C., Carrazco, C., Wright, P. Tags: Cerebrovascular Disease and Interventional Neurology: Patient Safety and Quality Source Type: research

Getting to the Core of Stroke Care: Real Time Chart Review Improves Hospital Compliance with Core Measures (P6.269)
Conclusions:Real time chart review, utilization of a MQA, and alerting of providers is significantly more effective than a process utilizing retrospective chart review based on sampling and manual abstraction in increasing CM compliance. Implementation of these methods reduces CM deficiencies and leads to improved stroke care.Disclosure: Dr. Katsafanas has nothing to disclose. Dr. Furbeyre has nothing to disclose. Dr. Coppen has nothing to disclose. Dr. Hodges has nothing to disclose. Dr. Schnepel has nothing to disclose. Dr. Falk has nothing to disclose. Dr. Alonso has nothing to disclose. Dr. Tran has nothing to disclose...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Katsafanas, C., Furbeyre, J., Coppen, V., Hodges, W., Schnepel, L., Falk, D., Alonso, J., Tran, A., Northcut, M., Toback, A., Silliman, S. Tags: Cerebrovascular Disease Health Services Research Source Type: research

Impact of Hospital Level on Stroke Outcomes in the Thrombolytic Therapy Era in Northeast Thailand: A Retrospective Study
ConclusionCHs may have the potential for acute ischemic stroke care in the same way as RHs or THs, with faster rt-PA treatment, in northeast Thailand. However, further studies should be performed to evaluate appropriate patient characteristics for CHs.
Source: Neurology and Therapy - May 18, 2021 Category: Neurology Source Type: research

J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats
ConclusionOur results demonstrate that J147 treatment alone exerts cerebral cytoprotective effects in a suture model of acute ischemic stroke, while in an embolic stroke model co-administration of J147 with tPA reduces delayed tPA-induced intracerebral hemorrhage and confers cerebroprotection. These findings suggest that J147-tPA combination therapy could be a promising approach to improving the treatment of ischemic stroke.
Source: Frontiers in Neurology - March 2, 2022 Category: Neurology Source Type: research

Using Routine Data for Quality Assessment in NeuroNet Telestroke Care
Background: Systematic clinical trials are often unavailable to evaluate and optimize operational telestroke networks. In a complementary approach, readily available routine clinical data were analyzed in this study to evaluate the effect of a telestroke network over a 4-year period.Methods: Routine clinical data from the HELIOS hospital information system were compared before and after implementation of the NeuroNet concept, including neurologic acute stroke teleconsultations, standard operating procedures, and peer review quality management in 3 hospital cohorts: 5 comprehensive stroke centers, 5 NeuroNet hospitals, and ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2012 Category: Neurology Authors: Stephan Theiss, Franziska Günzel, Anna Storm, Patrick Hausn, Stefan Isenmann, Joachim Klisch, Guntram W. Ickenstein, NeuroNet network Tags: Original Articles Source Type: research