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Specialty: Neurology
Therapy: Thrombolytic Therapy
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Total 551 results found since Jan 2013.
Update of Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
Acta Neurol Taiwan. 2021 Jun 30;30(2):44-53.ABSTRACTUpon acute ischemic stroke, rapid recanalization of the occluded cerebral vessel via intravenous thrombolytic therapy (IVT) is crucial to achieve good functional outcome. The time window of IVT with recombinant tissue plasminogen activator (rt-PA) has been extended from post-stroke 3 to 4.5 hours. In patients with cerebral penumbra identified using cerebral perfusion imaging, IVT is still beneficial within 4.5 to 9 hours after onset of stroke. For those without clear stroke onset time, DWI-FLAIR mismatch by brain MRI indicates hyperacute infarct and IVT is indicative. For...
Source: Acta Neurologica Taiwanica - September 22, 2021 Category: Neurology Authors: Li-Kai Tsai Jiann-Shing Jeng Source Type: research
CT Perfusion Variables Within 4.5 Hours Of Stroke: Relating Physiology To Time Since Onset (S35.007)
ConclusionsA decremental relationship between penumbra and time since onset appears to be one physiological mechanism underlying decreasing benefit of thrombolysis with time within 4.5 hours. This may be used to inform treatment in the clinical setting of strokes of unknown onset time, particularly using a simple visual assessment of CTp maps.Disclosure: Dr. Agarwal has nothing to disclose. Dr. Matys has nothing to disclose. Dr. Marrapu has nothing to disclose. Dr. Mitchell has nothing to disclose. Dr. Jones has nothing to disclose. Dr. Baron has nothing to disclose. Dr. Warburton has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Agarwal, S., Matys, T., Marrapu, S. T., Mitchell, J., Jones, P. S., Baron, J.-C., Warburton, E. Tags: Cerebrovascular Disease and Interventional Neurology: Issues in Acute Treatment Source Type: research
Specific Needs for Telestroke Networks for Thrombolytic Therapy in Japan
This study uncovered that many Japanese stroke hospitals, especially low-volume facilities located in rural areas, do not perform IV tPA therapy in 24/7 fashion and telestroke support to these hospitals may be highly effective compared with the drip-and-ship network in an underserved area.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Takeshi Imai, Kenzo Sakurai, Yuta Hagiwara, Heisuke Mizukami, Yasuhiro Hasegawa Tags: Original Articles Source Type: research
Do Elderly Patients Call 911 When Presented with Clinical Scenarios Suggestive of Acute Stroke A Cross-Sectional Study
Conclusions: These results suggest the need to provide interventions that are specifically designed to increase awareness of potential stroke signs and symptoms and appropriate subsequent clinical actions.Cerebrovasc Dis 2015;39:87-93
Source: Cerebrovascular Diseases - January 8, 2015 Category: Neurology Source Type: research
Safety and efficacy of desmoteplase given 3–9 h after ischaemic stroke in patients with occlusion or high-grade stenosis in major cerebral arteries (DIAS-3): a double-blind, randomised, placebo-controlled phase 3 trial
Publication date: Available online 30 April 2015 Source:The Lancet Neurology Author(s): Gregory W Albers , Rüdiger von Kummer , Thomas Truelsen , Jens-Kristian S Jensen , Gabriela M Ravn , Bjørn A Grønning , Hugues Chabriat , Ku-Chou Chang , Antonio E Davalos , Gary A Ford , James Grotta , Markku Kaste , Lee H Schwamm , Ashfaq Shuaib Background Current treatment of ischaemic stroke with thrombolytic therapy is restricted to 3–4·5 h after symptom onset. We aimed to assess the safety and efficacy of desmoteplase, a fibrin-dependent plasminogen activator, given between 3 h and 9 h after symptom onset in patients with ...
Source: The Lancet Neurology - May 1, 2015 Category: Neurology Source Type: research
In-Hospital Stroke
There have been tremendous strides in standardization of the care for acute ischemic stroke since widespread use of thrombolytic therapy began almost 20 years ago. Efficacy is still limited by delayed presentation to the emergency department following stroke symptom onset, although this has also improved in that period with education of emergency medical services and the community at large. The real improvement lies in development of streamlined and standardized protocols for “code stroke,” so that thrombolysis rates of 20% are becoming typical and door-to-needle times are just as typically under 1 hour. These encourag...
Source: JAMA Neurology - May 4, 2015 Category: Neurology Source Type: research
