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Nicotine Treatment Ameliorates Blood-Brain Barrier Damage After Acute Ischemic Stroke by Regulating Endothelial Scaffolding Protein Pdlim5
AbstractAnalysis of a National Institutes of Health (NIH) trial shows that cigarette smoking protected tissue plasminogen activator (tPA)-treated patients from hemorrhage transformation (HT); however, the underlying mechanism is not clear. Damage to the integrity of the blood-brain barrier (BBB) is the pathological basis of HT. Here, we investigated the molecular events of BBB damage after acute ischemic stroke (AIS) usingin vitro oxygen-glucose deprivation (OGD) andin vivo mice middle cerebral artery occlusion (MCAO) models. Our results showed that the permeability of bEND.3 monolayer endothelial cells was significantly i...
Source: Translational Stroke Research - May 26, 2023 Category: Neurology Source Type: research

Observational Study of Patients Hospitalized With Neurologic Events After SARS-CoV-2 Vaccination, December 2020-June 2021
Discussion All cases in this study were determined to have at least 1 risk factor and/or known etiology accounting for their neurologic syndromes. Our comprehensive clinical review of these cases supports the safety of mRNA COVID-19 vaccines.
Source: Neurology Clinical Practice - May 25, 2023 Category: Neurology Authors: Kim, C. Y., McNeill, E. N., Young, C., King, F., Clague, M., Caldwell, M., Boruah, A., Zucker, J., Thakur, K. T. Tags: Autoimmune diseases, Post-infectious, Inclusion, Diversity, Equity, Anti-racism, and Social Justice (IDEAS), COVID-19 Research Article Source Type: research

microRNA ‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease
ConclusionOur findings suggest miR-221 participates in the pathological process of PD and might be a potential drug target and provide new insight into PD treatment.
Source: Brain and Behavior - February 16, 2023 Category: Neurology Authors: Yufang Yao, Zhiyue Zhao, Fubo Zhang, Na Miao, Nan Wang, Xin Xu, Chaoping Yang Tags: ORIGINAL ARTICLE Source Type: research

Peroxiredoxin-3 Plays a Neuroprotective Role in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats
In conclusion, PRDX3 participates in neuronal protection by inhibiting the neuronal mitochondria-mediated death pathway; PRDX3 may be an important target for EBI intervention after SAH.PMID:36566946 | DOI:10.1016/j.brainresbull.2022.12.010
Source: Brain Research - December 25, 2022 Category: Neurology Authors: Haibo Li Zongqi Wang Xueshun Xie Muyun Luo Haitao Shen Xiang Li Haiying Li Zhong Wang Xiangdong Li Gang Chen Source Type: research

Peroxiredoxin-3 plays a neuroprotective role in early brain injury after experimental subarachnoid hemorrhage in rats
In conclusion, PRDX3 participates in neuronal protection by inhibiting the neuronal mitochondria-mediated death pathway; PRDX3 may be an important target for EBI intervention after SAH.PMID:36566946 | DOI:10.1016/j.brainresbull.2022.12.010
Source: Brain Research Bulletin - December 25, 2022 Category: Neurology Authors: Haibo Li Zongqi Wang Xueshun Xie Muyun Luo Haitao Shen Xiang Li Haiying Li Zhong Wang Xiangdong Li Gang Chen Source Type: research

Peroxiredoxin-3 Plays a Neuroprotective Role in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats
In conclusion, PRDX3 participates in neuronal protection by inhibiting the neuronal mitochondria-mediated death pathway; PRDX3 may be an important target for EBI intervention after SAH.PMID:36566946 | DOI:10.1016/j.brainresbull.2022.12.010
Source: Brain Research Bulletin - December 25, 2022 Category: Neurology Authors: Haibo Li Zongqi Wang Xueshun Xie Muyun Luo Haitao Shen Xiang Li Haiying Li Zhong Wang Xiangdong Li Gang Chen Source Type: research

Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3
CONCLUSIONS: This study is the first to indicate that inhibition of BRD4 delays fibrous scarring after ischemic stroke through mechanisms involving the phosphorylation of Smad2/3.PMID:36244457 | DOI:10.1016/j.brainres.2022.148126
Source: Brain Research - October 16, 2022 Category: Neurology Authors: Xuemei Li Huimin Zhu Jun Wen Jiagui Huang Yue Chen Mingfen Tian Jiangxia Ren Li Zhou Qin Yang Source Type: research

Administration of intramuscular AAV-BDNF and intranasal AAV-TrkB promotes neurological recovery via enhancing corticospinal synaptic connections in stroke rats
In this study, we performed non-invasive treatment methods focused on intramuscular injection into stroke-injured forelimb muscles, or intranasal administration using adeno-associated virus (AAV) vectors carrying genes encoding BDNF or TrkB. In a permanent rat middle cerebral artery occlusion (MCAO) model, we assessed the effects of combination therapy with AAV-BDNF and AAV-TrkB on motor functional recovery and synaptic plasticity of the corticospinal connections. Our results showed that BDNF or TrkB gene transduced in the spinal anterior horn neurons and cerebral cortical neurons. Compared to AAV vector treatment alone, b...
Source: Experimental Neurology - October 2, 2022 Category: Neurology Authors: Jing Wang Yichen Cai Jingyi Sun Hua Feng Xiaoyu Zhu Qian Chen Feng Gao Qingbin Ni Leilei Mao Mingfeng Yang Baoliang Sun Source Type: research

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