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The Functional Prognosis of Rescue Conscious Sedation During Mechanical Thrombectomy on Patients with Acute Anterior Circulation Ischemic Stroke: A Single-Center Retrospective Study
ConclusionCompared to LA, rescue CS during MT does  not significantly improve the 90 days of good prognosis and reduce the incidence of sICH and mortality in patients with anterior circulation AIS. However, it has a significantly increased risk of poststroke pneumonia (PSP), particularly in patients with dysphagia.
Source: Neurology and Therapy - August 2, 2023 Category: Neurology Source Type: research

Clinical application of 3DSlicer and Sina in minimally invasive puncture drainage of elderly patients with spontaneous intracerebral hemorrhage under local anesthesia
This study aimed to compare the treatment efficacy of MIPD conducted under local anesthesia using either 3DSlicer  + Sina application or computer tomography (CT)–guided stereotactic localization of hematomas in elderly patients diagnosed with ICH.
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2023 Category: Neurology Authors: Xiaolin Hou, Dingjun Li, Yuan Yao, Lin Zeng, Chengxun Li Source Type: research

Polish recommendations for diagnosis and therapy of paediatric stroke
Neurol Neurochir Pol. 2023 May 5. doi: 10.5603/PJNNS.a2023.0034. Online ahead of print.ABSTRACTStroke remains one of the greatest health challenges worldwide, due to a high mortality rate and, despite great progress in its treatment, the significant disability that it causes. Studies conducted around the world show that the diagnosis of stroke in children is often significantly delayed. Paediatric ischaemic arterial stroke (PAIS) is not only a problem that varies greatly in frequency compared to the adult population, it is also completely different in terms of its risk factors, clinical course and outcome. The main reason ...
Source: Neurologia i Neurochirurgia Polska - May 5, 2023 Category: Neurology Authors: Ewa Pilarska Ilona Kopyta Edyta Szurowska Julia Rado ń-Proskura Ninela Irga-Jaworska Grzegorz Kozera Robert Sabiniewicz Ewa Emich-Widera Joanna Wojczal Source Type: research

Neurological scoring and gait kinematics to assess functional outcome in an ovine model of ischaemic stroke
ConclusionThis study developed repeatable methods to assess function in sheep using composite scoring and gait kinematics, allowing for the evaluation of deficit 3 days post-stroke. Despite utility of each method independently, there was poor association observed between gait kinematics, composite scoring, and infarct volume on PCA. This suggests that each of these measures has discreet utility for the assessment of stroke deficit, and that multimodal approaches are necessary to comprehensively characterise functional impairment.
Source: Frontiers in Neurology - February 20, 2023 Category: Neurology Source Type: research

Protecting the injured central nervous system: Do anesthesia or hypothermia ameliorate secondary injury?
Exp Neurol. 2023 Feb 10:114349. doi: 10.1016/j.expneurol.2023.114349. Online ahead of print.ABSTRACTTraumatic injury to the central nervous system (CNS) and stroke initiate a cascade of processes that expand the area of tissue loss. The current review considers recent studies demonstrating that the induction of an anesthetic state or cooling the affected tissue (hypothermia) soon after injury can have a therapeutic effect. We first provide an overview of the neurobiological processes that fuel tissue loss after traumatic brain injury (TBI), spinal cord injury (SCI) and stroke. We then examine the rehabilitative effectivene...
Source: Experimental Neurology - February 12, 2023 Category: Neurology Authors: Jacob A Davis James W Grau Source Type: research

Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
CONCLUSION: From these results, it was observed that CD treatment could reduce neuronal necrosis and create anti-inflammatory, anti-edema, anti-oxidant, anti-apoptotic, and anti-autophagic effects in hypoxia/reperfusion injury in rats.PMID:36548871 | DOI:10.1080/01616412.2022.2159109
Source: Neurological Research - December 22, 2022 Category: Neurology Authors: Alemiddin Ozdemir Mustafa Ogden Bahar Kartal Asli Fahriye Ceylan Ulas Yuksel Bulent Bakar Source Type: research

Predictors of Symptomatic Intracranial Hemorrhage after Endovascular Thrombectomy in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Conclusions: This study identified many predictors of sICH. Some of the results lack robust evidence given the limitations of the study. Therefore, larger cohort studies are needed to confirm these predictors.Cerebrovasc Dis
Source: Cerebrovascular Diseases - November 24, 2022 Category: Neurology Source Type: research

Dysphagia assessment in ischemic stroke after mechanical thrombectomy: When and how?
ConclusionsPSD is a frequent finding both immediately within 24 h after extubation, as well as in the short-term course. In contrast to common clinical practice, to delay evaluation of swallowing for at least 24 h post-extubation, we recommend a timely assessment of swallowing function after extubation, as 50% of patients were safe to begin oral intake. Given the high amount of severe dysphagic symptoms, we strongly recommend application of instrumental swallowing diagnostics due to its higher sensitivity, when compared to clinical swallowing examination. Furthermore, advanced age, as well as prolonged intubation, were ide...
Source: Frontiers in Neurology - November 23, 2022 Category: Neurology Source Type: research

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