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Proteinuria and Risk for Heart Failure in 55,191 Patients Having History of Cancer
We examined the association of proteinuria with the risk for heart failure (HF) and other cardiovascular disease (CVD) events in patients with prior history of breast, colorectal, or stomach cancer using a nationwide population-based database.Methods: We conducted this retrospective observation study using the JMDC Claims Database and analyzed 55,191 patients with prior history of breast, colorectal, or stomach cancer. The median age was 54 (48 –60) years, and 20,665 participants (37.4%) were men. Using urine dipstick data at baseline, 3,945 and 1,521 participants were categorized as having trace and positive proteinuria...
Source: American Journal of Nephrology - December 21, 2022 Category: Neurology Source Type: research

Pure Thalamic Infarct: 8-Year Follow-Up Study in a Hospital in China
In conclusion, our cohort of pure thalamic infarcts were mainly due to SVO (TOAST), with hypertension as the main risk factor, and the inferolateral artery as the most implicated arterial territory. Less severe outcome or stroke recurrence are identified in long-term follow-up of pure thalamic infarcts. Other comorbidities would be cause of death in aged patients.
Source: Frontiers in Neurology - September 14, 2021 Category: Neurology Source Type: research

Lynch syndrome-associated repeated stroke with MLH1 frame-shift mutation
We describe the case of a 34-year-old female patient with 50  days of sudden dizziness and left limb weakness, whose head CT scan showed large infarction in the right frontal temporal parietal lobe and basal ganglia area. Imaging examinations and pathological biopsy indicated high-grade serous carcinoma (HGSC) IIIA1 of the right ovary. In addition, a novel f rame-shift mutation in the MLH1 gene (c.1621dupG, p.A541Gfs*16) was found in the genetic panel sequence. It may render declining of MLH1 protein and also associate with the patient’s progressive clinical manifestations of multiple systems. Therefore, the timely use ...
Source: Neurological Sciences - January 12, 2021 Category: Neurology Source Type: research

New Cancer Diagnosis Linked to Increased Stroke Risk New Cancer Diagnosis Linked to Increased Stroke Risk
A diagnosis of cancer -- particularly lung, pancreatic, or colorectal cancer -- is associated with an increased short-term risk for stroke, a new study suggests. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - January 9, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Prior Cancer in Patients with Ischemic Stroke: The Bergen NORSTROKE Study
Conclusions: The prevalence of prior cancer is higher in ISP than in the general population. ISPs with prior cancer are more prone to cardioembolism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 27, 2013 Category: Neurology Authors: Henriette A. Selvik, Lars Thomassen, Nicola Logallo, Halvor Næss Tags: Original Articles Source Type: research

Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients – an observational study
Conclusions Bevacizumab acutely impairs microvascular function independent of blood pressure changes. Imaging of the retinal microcirculation seems a valuable tool for monitoring pharmacodynamic effects of bevacizumab. Trial registration NCT ID: NCT00740168
Source: Experimental and Translational Stroke Medicine - May 13, 2013 Category: Neurology Source Type: research