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Specialty: Neurology
Education: Lessons
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Total 70 results found since Jan 2013.
Personalised simulation of hemodynamics in cerebrovascular disease: lessons learned from a study of diagnostic accuracy
In this study, we performed the first quantitative validation of a simulation-based precision medicine framework to assess cerebral hemodynamics in patients with ICAD against clinical standard perfusion imaging. In a retrospective analysis, we used a 0-dimensional simulation model to detect brain areas that are hemodynamically vulnerable to subsequent stroke. The main outcome measures were sensitivity, specificity, and area under the receiver operating characteristics curve (ROC AUC) of the simulation to identify brain areas vulnerable to subsequent stroke as defined by quantitative measurements of relative mean transit ti...
Source: Frontiers in Neurology - September 12, 2023 Category: Neurology Source Type: research
Neurological monitoring in ECMO patients: current state of practice, challenges and lessons
ConclusionNeurological monitoring in ECMO is an area of interest to many clinicians, however, the literature is limited, heterogenous, and lacks consensus on the best monitoring practices. The evidence for optimal neurological monitoring that could impact clinical decisions and functional outcomes is lacking. Additional studies are needed to identify effective measures of neurological monitoring while on ECMO.
Source: Acta Neurologica Belgica - January 26, 2023 Category: Neurology Source Type: research
Revisiting Transcranial Light Stimulation as a Stroke Therapeutic —Hurdles and Opportunities
AbstractNear-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the e...
Source: Translational Stroke Research - November 12, 2022 Category: Neurology Source Type: research
Cerebral fat embolism syndrome at a single trauma center
Based on a 16-year case series, we sought lessons about diagnosis and treatment of cerebral fat embolism syndrome.
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2022 Category: Neurology Authors: Amita Singh, Arielle P. Davis, Breana Taylor, Steven Peters, David Tirschwell, W.T. Longstreth, Mahmud Mossa-Basha, Michael Nash, Sandeep P. Khot Tags: Short Communication Source Type: research
Correction to: The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium
Source: Translational Stroke Research - September 27, 2022 Category: Neurology Source Type: research
The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium
This study comprised 671 patients (median age 61.4 years; 71.2% female) with 682 intracranial aneurysms. Over time, we observed an increasing tendency to treat patients presenting with ruptured aneurysms and aneurysms with smaller neck, diameter, and dome widths. Furthermore, we observed a trend towards more off-label use of the WEB for sidewall aneurysms and increased adoption of transradial access for WEB deployment. Moreover, the proportion of patients with adequate WEB o cclusion immediately and at last follow-up was significantly higher in more recent year cohorts, as well as lower rates of compaction and retreatment...
Source: Translational Stroke Research - September 6, 2022 Category: Neurology Source Type: research
A painful lesson: painless aortic dissection misdiagnosed as acute stroke was treated with intravenous thrombolysis
Source: Acta Neurologica Belgica - August 27, 2022 Category: Neurology Source Type: research
Lessons Learned From the Historical Trends on Thrombolysis Use for Acute Ischemic Stroke Among Medicare Beneficiaries in the United States
ConclusionsBetween 2007 and 2014, the frequency of IVT for patients with acute ischemic stroke increased substantially, though differences persisted in the form of less frequent treatment associated with certain characteristics. These findings can inform ongoing efforts to optimize the delivery of IVT to all AIS patients nationwide.
Source: Frontiers in Neurology - March 4, 2022 Category: Neurology Source Type: research
Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Both conditions are characterized by disturbed homeostasis in which inflammatory pathways play a central role. Splanchnic vasoconstriction, increased gut permeability, gut-related endotoxemia, systemic inflammatory response, central nervous system dysfunction, blood coagulation disorder, endothelial-cell injury, and mitochondrial dysfunction underlie heat stroke. These mechanisms have also been documented in ME/CFS. Moreover, initial transc...
Source: Frontiers in Neurology - December 13, 2021 Category: Neurology Source Type: research
Transcranial magnetic stimulation to assess motor neurophysiology after acute stroke in the United States: Feasibility, lessons learned, and values for future research
Transcranial magnetic stimulation (TMS) has been widely applied in both basic and clinical neuroscience since its introduction in 1985. In addition to its potential therapeutic value for exciting or inhibiting neural circuits [1], TMS can be used to investigate corticomotor excitability (CME), which is a key aspect of voluntary movement [2]. For example, single-pulse TMS can elicit electrical signals, which propagate along descending motor pathways and are recorded as motor evoked potentials (MEP) in target muscles.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 6, 2021 Category: Neurology Authors: Yi-Ling Kuo, David J. Lin, Isha Vora, Julie A. DiCarlo, Dylan J. Edwards, Teresa J. Kimberley Source Type: research
Lessons learned in stroke care during COVID-19 pandemic and preparing for future pandemics in the MENA+ region: A consensus statement from the MENA+-SINO
COVID-19 pandemic has negatively impacted stroke care services at multiple levels. There was a decline in acute stroke admissions. Fewer interventions have been performed. Increased “door-to-needle times and “door-to-groin puncture” during this pandemic. These factors combined have led to declining in the favoured outcomes of stroke patients' globally. Yet this pandemic permits an opportunity for higher preparedness for future pandemics.
Source: Journal of the Neurological Sciences - November 26, 2021 Category: Neurology Authors: Amal .M. Al Hashmi, Stephan von Bandemer, Ashfaq Shuaib, Ossama Yassin Mansour, Mohammed Wassy, Atilla Ozacn Ozdemir, Mehdi Farhoudi, Hosam Al Jehani, Adnan Khan, Seby John, Maher Saqqur, On the behalf of MENA-SINO Organization Source Type: research
Fifty Years of Acute Ischemic Stroke Treatment: A Personal History
Background: It has been 50 years since the first explorations of the physiology of cerebral ischemia by measuring cerebral blood flow (CBF), and 25 years since the approval of tissue plasminogen activator for treating acute ischemic stroke. My personal career began and matured during those eras. Here, I provide my perspective on the evolution of acute stroke research and treatment from 1971 to the present, with some in-depth discussion of the National Institutes of Neurologic Disease and Stroke (NINDS) tissue-type plasminogen activator (tPA) stroke trial and development of mobile stroke units.Summary: Studies of CBF and me...
Source: Cerebrovascular Diseases - October 14, 2021 Category: Neurology Source Type: research
Computational Fluid Dynamics in Intracranial Atherosclerosis - Lessons from Cardiology: A Review of CFD in Intracranial Atherosclerosis
Intracranial atherosclerotic disease (ICAD) is a common cause of stroke1 associated with high stroke recurrence rates.2 There is accumulating evidence that haemodynamically significant intracranial atherosclerotic lesions are associated with increased rates of recurrent stroke.3-7
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2021 Category: Neurology Authors: Davor Pavlin-Premrl, Sethu R. Boopathy, Andras Nemes, Milad Mohammadzadeh, Sadaf Monajemi, Brian S. Ko, Bruce C.V. Campbell Tags: Review Article Source Type: research
