Filtered By:
Specialty: Neurology
Condition: Subarachnoid Hemorrhage
This page shows you your search results in order of date. This is page number 9.
Order by Relevance | Date
Total 1836 results found since Jan 2013.
Cerebral Aneurysm and Interleukin-6: a Key Player in Aneurysm Generation and Rupture or Just One of the Multiple Factors?
AbstractIntracranial aneurysm (IA) rupture is a common cause of subarachnoid hemorrhage (SAH) with high mortality and morbidity. Inflammatory interleukins (IL), such as IL-6, play an important role in the occurrence and rupture of IA causing SAH. With this review we aim to elucidate the specific role of IL-6 in aneurysm formation and rupture in preclinical and clinical studies. IL-6 is a novel cytokine in that it has pro-inflammatory and anti-inflammatory signaling pathways. In preclinical and clinical studies of IA formation, elevated and reduced levels of IL-6 are reported. Poor post-rupture prognosis and increased ruptu...
Source: Translational Stroke Research - August 31, 2022 Category: Neurology Source Type: research
The Role of Neutrophil Extracellular Traps in Early Microthrombosis and Brain Injury After Subarachnoid Hemorrhage in Mice
In conclusion, NETs are associated with early microthrombosis after SAH; they may be a novel therapeutic target for early brain injury (EBI) after SAH.
Source: Translational Stroke Research - August 13, 2022 Category: Neurology Source Type: research
Vitamin D level is associated with rupture of intracranial aneurysm in patients with subarachnoid hemorrhage
ConclusionVitamin D level is associated with rupture of intracranial aneurysm in patients with SAH. Patients with aneurysmal SAH have lower vitamin D levels than those with non-aneurysmal SAH.
Source: Frontiers in Neurology - August 11, 2022 Category: Neurology Source Type: research
ASPECT Score and Its Application to Vasospasm in Aneurysmal Subarachnoid Haemorrhage: a Case –Control Study
AbstractDelayed cerebral ischaemia (DCI) is a significant complication of aneurysmal subarachnoid haemorrhage (aSAH) and is strongly associated with poorer outcome. The Alberta Stroke Program Early Computer Tomography (ASPECT) score is an established scoring tool, used in acute ischaemic stroke, to quantify early ischaemic changes on CT head scans. We aim to identify if ASPECT scoring correlates with functional outcome in DCI following aSAH. Retrospective case –control study. Inclusion criteria: admission to the Department of Neurosurgery at Leeds Teaching Hospitals NHS Trust (a tertiary neurosurgical centre in the Unite...
Source: Translational Stroke Research - August 9, 2022 Category: Neurology Source Type: research
Short- and long-term mortality of subarachnoid hemorrhage according to hospital volume and severity using a nationwide multicenter registry study
ConclusionShort- and long-term mortality in patients with SAH differed according to hospital volume. In the modern endovascular era, clipping and coiling can lead to better outcomes in facilities with high stroke-care capabilities.
Source: Frontiers in Neurology - August 5, 2022 Category: Neurology Source Type: research
Augmented Renal Clearance in Patients with Acute Ischemic Stroke: A Prospective Observational Study
ConclusionsARC appears to manifest in patients with AIS inconsistently. Patients experiencing ARC were associated with nonsignificantly shorter ICU length of stay.
Source: Neurocritical Care - August 3, 2022 Category: Neurology Source Type: research
Serum glial fibrillary acidic protein (GFAP) predicts outcome after intracerebral and subarachnoid hemorrhage
ConclusionsElevated GFAP levels at admission to hospital predicted mortality and poor outcome in our cohort of intracerebral and subarachnoid hemorrhage patients. Neuroglobin levels did not provide additional information. Combining GFAP measurements with clinical disease severity scores increased outcome prediction precision. This may suggest that GFAP measurement could improve prognostication in patients with intracerebral or subarachnoid hemorrhage.Registration: This sub-trial was not registered.
Source: Neurological Sciences - July 27, 2022 Category: Neurology Source Type: research
A Nationwide Analysis of Aneurysmal Subarachnoid Hemorrhage Mortality, Complications, and Health Economics in the USA
In conclusion, patients with aSAH have high post-operative complication ra tes and costs. Development of novel interventions to reduce complications and improve outcomes is crucial.
Source: Translational Stroke Research - July 26, 2022 Category: Neurology Source Type: research
Inhibition of Mer exacerbates early brain injury by regulating microglia/macrophage phenotype after subarachnoid hemorrhage in mice
In this study, we explored the effect of Mer on modulating the microglia/macrophage phenotype and neuroinflammation and possible potential mechanism after SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2022 Category: Neurology Authors: Xiaoxiao Tan, Yonghe Zheng, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Shenglong Cao Source Type: research
T3 alleviates neuroinflammation and reduces early brain injury after subarachnoid haemorrhage by promoting mitophagy via PINK 1-parkin pathway
Exp Neurol. 2022 Jul 19:114175. doi: 10.1016/j.expneurol.2022.114175. Online ahead of print.ABSTRACTSubarachnoid haemorrhage (SAH) is a common and devastating complication of haemorrhagic stroke. SAH is characterised by high mortality rates, permanent disabilities, and is often caused by the rupture of intracranial aneurysms. Low serum triiodothyronine (T3) concentrations have been associated with severe SAH and poor prognosis. T3 has been previously described as an inhibitor of lung fibrosis, and it acts by stimulating autophagy and mitophagy. Here, we indicated in vitro that T3 treatment suppressed neuronal apoptosis by ...
Source: Experimental Neurology - July 22, 2022 Category: Neurology Authors: Hanxiao Chang Chao Lin Zheng Li Yuqi Shen Guangjian Zhang Lei Mao Chencheng Ma Ning Liu Hua Lu Source Type: research
Metformin Alleviates Delayed Hydrocephalus after Intraventricular Hemorrhage by Inhibiting Inflammation and Fibrosis
In conclusion, metformin attenuated neuroinflammation and subsequent fibrosis after IVH by regulating AMPK /SIRT1/ NF-κB pathways, thereby reducing delayed hydrocephalus. Metformin may be a promising therapeutic agent to prevent delayed hydrocephalus following IVH.
Source: Translational Stroke Research - July 19, 2022 Category: Neurology Source Type: research
Sustained ICP Elevation Is a Driver of Spatial Memory Deficits After Intraventricular Hemorrhage and Leads to Activation of Distinct Microglial Signaling Pathways
In this study, we show that intraventricular hemorrhage only leads to a significant spatial memory deficit in the Morris water maze if it occurs in the setting of an elevated intracranial pressure (ICP). Histopathological analysis of these IVH + ICP animals did not show evidence of neuronal degeneration in the hippocampal formation after 2 weeks but instead showed significant microglial activation measured by lacunarity and fractal dimensions. RNA sequencing of the hippocampus showed distinct enrichment of genes in the IVH + ICP group but not in IVH alone having activated microglial signaling pathways. The most s...
Source: Translational Stroke Research - July 12, 2022 Category: Neurology Source Type: research
NLRP3 Inflammasome Overactivation in Patients with Aneurysmal Subarachnoid Hemorrhage
AbstractAneurysmal subarachnoid hemorrhage (aSAH) is an uncommon and severe subtype of stroke leading to the loss of many years of productive life. We analyzed NLRP3 activity as well as key components of the inflammasome cascade in monocytes and plasma from 28 patients with aSAH and 14 normal controls using flow cytometry, western blot, ELISA, and qPCR technologies. Our data reveal that monocytes from patients with aSAH present an overactivation of the NLRP3 inflammasome, which results in the presence of high plasma levels of interleukin (IL)-1 β, IL-18, gasdermin D, and tissue factor. Although further research is needed,...
Source: Translational Stroke Research - July 11, 2022 Category: Neurology Source Type: research
Association of cerebrospinal fluid advanced oxidation protein products levels with early brain injury and prognosis of aneurysmal subarachnoid hemorrhage: A preliminary prospective study
In this study, we investigated the time course in the cerebrospinal fluid (CSF) advanced oxidation protein products (AOPPs) levels in patients with aneurysmal subarachnoid hemorrhage (aSAH), and ascertained the relationship between the levels of AOPPs and early brain injury (EBI), hydrocephalus and prognosis of patients with aSAH.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2022 Category: Neurology Authors: Ying-Jie Shen, Hui-Yu Hu, Zhong-Jun Wei, Meng-Kai Li, Yi Wang, Guang-Yu Shi, Xue-Hong Chu, Shao-Yu Liu, Guo-Qiang Xue Source Type: research
Body structure/function impairments and activity limitations of post-stroke that predict social participation: a systematic review
CONCLUSION: There is some evidence that stroke severity, mental and motor deficits, limitations in activities of daily living and the ability to walk after a stroke can predict social participation in the community. PROSPERO registration CRD42020177591.PMID:35787246 | DOI:10.1080/10749357.2022.2095086
Source: Topics in Stroke Rehabilitation - July 5, 2022 Category: Neurology Authors: Flaviane Ribeiro de Souza Matheus Sales Larrie Rabelo Laporte Ailton Melo Nildo Manoel da Silva Ribeiro Source Type: research
