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Specialty: Neurology
Condition: Peripheral Neuropathy

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Total 64 results found since Jan 2013.

Pay attention: you can fall! The Mini-BESTest scale and the turning duration of the TUG test provide valid balance measures in neurological patients: a prospective study with falls as the balance criterion
ConclusionThe TUG turning duration and the Mini-BESTest predict the chance of being a faller. Their criterion validity as balance measures in neurological patients is substantial.
Source: Frontiers in Neurology - September 8, 2023 Category: Neurology Source Type: research

Neuropathology of central nervous system involvement in TTR amyloidosis
AbstractHereditary transthyretin amyloidosis (ATTRv) is a systemic disease caused by the accumulation of misfolded transthyretin (TTR). It usually presents with an adult-onset progressive axonal peripheral neuropathy and cardiomyopathy. In the central nervous system (CNS), variant TTR is produced by the choroid plexus and accumulates in the leptomeninges. CNS symptoms have been increasingly recognized in this population, including transient focal neurological episodes and stroke, particularly in patients with the V30M mutation and longstanding disease. The prevalence, pathophysiology, and progression of CNS involvement rem...
Source: Acta Neuropathologica - January 1, 2023 Category: Neurology Source Type: research

Clinical features, etiology, and prognosis of hand knob stroke: a case series
Hand knob stroke is a rare clinical disorder frequently misdiagnosed as peripheral neuropathy. The purpose of this study is to recognize this particular type of stroke by analyzing clinical features, etiology,...
Source: BMC Neurology - September 2, 2022 Category: Neurology Authors: Zhiyong Zhang, Xiaoxin Sun, Xinxiu Liu, Lei Wang and Rui Zhu Tags: Research Source Type: research

Neurological Manifestations of Coronavirus Disease 2019: A Comprehensive Review and Meta-Analysis of the First 6 Months of Pandemic Reporting
Conclusions: The COVID-19 pandemic exerts a substantial neurologic burden which may have residual effects on patients and healthcare systems for years. Low quality evidence impedes the ability to accurately predict the magnitude of this burden. Robust studies with standardised screening and case definitions are required to improve understanding of this disease and optimise treatment of individuals at higher risk for neurologic sequelae.
Source: Frontiers in Neurology - August 12, 2021 Category: Neurology Source Type: research

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection
This article describes the spectrum of neurologic complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, their underlying pathology and pathogenic mechanisms, gaps in knowledge, and current therapeutic strategies. RECENT FINDINGS COVID-19 is the clinical syndrome caused by the novel coronavirus SARS-CoV-2. It can affect the entire neuraxis, and presentations in the acute phase are variable, although anosmia is a common manifestation. Encephalopathy is common in patients who are hospitalized and is often associated with multiorgan involvement. Immune-mediated encephaliti...
Source: CONTINUUM: Lifelong Learning in Neurology - August 1, 2021 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Vasculitic peripheral neuropathy in deficiency of adenosine deaminase 2 (DADA2)
Deficiency of Adenosine Deaminase 2 (DADA2) is an autosomal recessive inflammatory vasculopathy described in 2014.(1,2) It is caused by a loss-of-function mutation of adenosine deaminase 2 (ADA2) gene. One of its phenotypes is characterized by systemic vasculitis, early-onset stroke and a livedoid rash known as livedo racemosa (LR).(1) Previously to the genetic discovery, DADA2 was present in part of the patients labelled with Sneddon's Syndrome (SnS), an unspecific clinical diagnosis comprising stroke and a cutaneous livedoid rash.(3,4)
Source: Neuromuscular Disorders - May 14, 2021 Category: Neurology Authors: D Reis Carneiro, O Rebelo, A Matos, I Baldeiras, L Almendra, C Fernandes, L Negr ão, MR Almeida, F Matias, J Brás, R Guerreiro, GC Santo Tags: Case report Source Type: research

Vasculitic peripheral neuropathy in deficiency of adenosine deaminase 2
Deficiency of Adenosine Deaminase 2 (DADA2) is an autosomal recessive inflammatory vasculopathy described in 2014 [1,2]. It is caused by a loss-of-function mutation of adenosine deaminase 2 (ADA2) gene. One of its phenotypes is characterized by systemic vasculitis, early-onset stroke and a livedoid rash known as livedo racemosa (LR) [1]. Previously to the genetic discovery, DADA2 was present in part of the patients labelled with Sneddon's Syndrome (SnS), an unspecific clinical diagnosis comprising stroke and a cutaneous livedoid rash [3,4].
Source: Neuromuscular Disorders - May 14, 2021 Category: Neurology Authors: Diogo Reis Carneiro, Olinda Rebelo, Anabela Matos, In ês Baldeiras, Luciano Almendra, Carolina Fernandes, Luís Negrão, Maria Rosário Almeida, Fernando Matias, José Brás, Rita Guerreiro, Gustavo C Santo Tags: Case report Source Type: research

Neurological impact of eosinophilic granulomatosis with polyangiitis
AbstractNervous system (NS)  affection may occur in Eosinophilic Granulomatosis with Polyangiitis (EGPA), but its clinical manifestations and pathophysiology are rarely described. Our aims are to characterize central and peripheral NS (CNS/PNS) involvement and compare biological markers in EGPA patients with and w ithout neurological manifestations. Retrospective observational study, including EGPA patients with and without neurological manifestations. Demographics, clinical data, and immunological markers were analyzed. Descriptive and inferential statistics were performed. Sixteen patients were included ...
Source: Acta Neurologica Belgica - April 27, 2021 Category: Neurology Source Type: research

COVID-19 Pathophysiology Predicts That Ischemic Stroke Occurrence Is an Expectation, Not an Exception —A Systematic Review
This study provides a comprehensive review of the pathobiology of COVID-19 and ischemic stroke. It also affirms that the immunological contribution to the pathophysiology of COVID-19 is predictive of the neurological sequelae particularly ischemic stroke, which makes it the expectation rather than the exception. This work is of fundamental significance to the neurorehabilitation community given the increasing number of COVID-related ischemic strokes, the current limited knowledge regarding the risk of reinfection, and recent reports of a PCNS. It further highlights the need for global collaboration and research into new pa...
Source: Frontiers in Neurology - January 28, 2021 Category: Neurology Source Type: research

Sudomotor Dysfunction
Semin Neurol DOI: 10.1055/s-0040-1713847Disorders of sudomotor function are common and diverse in their presentations. Hyperhidrosis or hypohidrosis in generalized or regional neuroanatomical patterns can provide clues to neurologic localization and inform neurologic diagnosis. Conditions that impair sudomotor function include small fiber peripheral neuropathy, sudomotor neuropathy, myelopathy, α-synucleinopathies, autoimmune autonomic ganglionopathy, antibody-mediated hyperexcitability syndromes, and a host of medications. Particularly relevant to neurologic practice is the detection of postganglionic sudomotor deficits ...
Source: Seminars in Neurology - September 8, 2020 Category: Neurology Authors: Cheshire, William P. Tags: Review Article Source Type: research

Rheumatologic Disorders and the Nervous System
This article describes the neurologic manifestations of systemic autoimmune diseases. RECENT FINDINGS Systemic autoimmune diseases can be associated with a wide spectrum of neurologic comorbidities involving the central and peripheral nervous systems. Systemic lupus erythematosus (SLE) can be associated with a number of manifestations predominantly affecting the central nervous system (CNS), whereas peripheral neuropathy is less common. Sjögren syndrome can be associated with peripheral neuropathy in 10% of cases and CNS disease in 2% to 5% of cases. The risk of stroke is increased in SLE, rheumatoid arthritis, tempora...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Iatrogenesis and neurological manifestations in the elderly.
Authors: Zerah L, Bihan K, Kohler S, Mariani LL Abstract Older people are often exposed to polypharmacy in a multimorbidity context. Inappropriate polypharmacy is often harmful, increasing the risk of inappropriate prescriptions and therefore adverse drug events (ADEs). Five to 20% of all hospital admissions are related to ADE in older people, among which 40 to 70% could be prevented. However, identifying ADEs and drug-related admissions in the elderly is challenging because ADEs often present as common geriatric problems such as falls, delirium, which might be due to the aging process, underlying diseases, and/or ...
Source: Revue Neurologique - May 13, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Recurrent Stroke-Like Symptoms After Cesarean Section Deliveries in a Female Patient With X-Linked Charcot-Marie-Tooth Type 1
Conclusion: The diagnosis of CMTX1 should be considered, even in female patients, when the disease presents with recurrent stroke-like symptoms and abnormal white matter signals on MRI. The puerperium after delivery may be one of the precipitating factors.
Source: Frontiers in Neurology - January 27, 2020 Category: Neurology Source Type: research

CT perfusion and EEG patterns in patients with acute isolated aphasia in seizure-related stroke mimics
Stroke mimic (SM) is a set of conditions with clinical presentation similar to that of an acute ischemic stroke (AIS), albeit not caused by an ischemic event [1]. From 1% to 41% of patients presenting stroke-like symptoms at admission to the Emergency Department are actually SM [2]. The most common SM etiologies are seizure (38%), migraine with aura (37%), and conversion disorder (21%) [3]. Other conditions of SM are metabolic, infectious, neurodegenerative disorder, peripheral neuropathy and syncope [3].
Source: Seizure: European Journal of Epilepsy - July 3, 2019 Category: Neurology Authors: Paolo Manganotti, Giovanni Furlanis, Milo š Ajčević, Paola Polverino, Paola Caruso, Mariana Ridolfi, Roberta Antea Pozzi-Mucelli, Maria Assunta Cova, Marcello Naccarato Source Type: research