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Total 154 results found since Jan 2013.

Sensors ‐based monitoring and treatment approaches for in‐stent restenosis
AbstractCardiovascular disease (CVD) can progressively narrow arteries due to plaque accumulation on the inner walls of the blood vessels, which results in an obstructed blood flow, leading to heart attack, stroke, and even death if the obstruction is severe. A popular treatment for the disease is to use an intravascular mechanical device called the stent to achieve an immediate restoration of blood flow. However, the physical stimulation induced by the stent expansion can cause inflammation of the vessel tissue. As one of the most common post-stenting complications, re-narrowing of the vessel is the main pathology that le...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 26, 2022 Category: Materials Science Authors: Ying Yi, Bo Wang, Changping Li Tags: REVIEW ARTICLE Source Type: research

Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach"
Biomaterials. 2022 Sep 15;289:121805. doi: 10.1016/j.biomaterials.2022.121805. Online ahead of print.ABSTRACTTreatment of Ischemic Stroke is inordinately challenging due to its complex aetiology and constraints in shuttling therapeutics across blood-brain barrier. Ropinirole hydrochloride (Rp), a propitious neuroprotectant with anti-oxidant, anti-inflammatory, and anti-apoptotic properties (3A) is repurposed for remedying ischemic stroke and reperfusion (I/R) injury. The drug's low bioavailability in brain however, limits its therapeutic efficacy. The current research work has reported sub-100 nm gamma-L-Glutamyl-L-Cystein...
Source: Biomaterials - September 26, 2022 Category: Materials Science Authors: Saman Fatima Mubashshir Ali Syed Naved Quadri Sarwar Beg M Samim Suhel Parvez Malik Zainul Abdin Prashant Mishra Farhan Jalees Ahmad Source Type: research

ASAP Correction to “A Co-Doped Fe 3 O 4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke ”
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c12150
Source: ACS Applied Materials and Interfaces - September 19, 2022 Category: Materials Science Authors: Yunsheng Liu, Xiaojun Wang, Xiangzhu Li, Shanshan Qiao, Guodong Huang, Dirk Matthias Hermann, Thorsten Roland Doeppner, Muling Zeng, Wei Liu, Gelin Xu, Lijie Ren, Yuan Zhang, Wenlan Liu, Eudald Casals, Weiping Li, and Ya-Chao Wang Source Type: research

Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study
This study focuses on two aspects of the thrombectomy simulation: i) Thrombus fragmentation on the basis of a failure model calibrated with experimental tests on clot analogs; ii) the combined stent-retriever and aspiration catheter MT procedure is modeled by adding both the proximal balloon guide catheter and the distal access catheter. The adopted failure criterion is based on maximum principal stress threshold value. If elements of the thrombus exceed this criterion during the retrieval simulation, then they are deleted from the calculation. Comparison with in-vitro tests indicates that the simulation correctly reproduc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 18, 2022 Category: Materials Science Authors: Giulia Luraghi Sara Bridio Vittorio Lissoni Gabriele Dubini Anushree Dwivedi Ray McCarthy Behrooz Fereidoonnezhad Patrick McGarry Frank J H Gijsen Jose Felix Rodriguez Matas Francesco Migliavacca Source Type: research

Patient-specific biomechanical analysis of atherosclerotic plaques enabled by histologically validated tissue characterization from computed tomography angiography: A case study
CONCLUSION: Patient specific tissue characterization can identify distributions of stress and strain in a clinically relevant range. This capability may be used to identify high-risk lesions and personalize treatment decisions for individual patients with cardiovascular disease and improve prevention of myocardial infarction and stroke.PMID:36049368 | DOI:10.1016/j.jmbbm.2022.105403
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 1, 2022 Category: Materials Science Authors: Andrew J Buckler Max van Wanrooij M åns Andersson Eva Karl öf Ljubica Perisic Matic Ulf Hedin T Christian Gasser Source Type: research

A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
Biomaterials. 2022 Aug 15:121729. doi: 10.1016/j.biomaterials.2022.121729. Online ahead of print.ABSTRACTBrain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one of the leading causes of hemorrhagic stroke in children and young adults. Most human sporadic brain AVMs are associated with genetic activating mutations in the KRAS gene. Our goal was to develop an in vitro model that would allow for simultaneous morphological and functional phenotypic data capture in real time during AVM disease progress...
Source: Biomaterials - August 23, 2022 Category: Materials Science Authors: Kayla Soon Mengyuan Li Ruilin Wu Angela Zhou Negar Khosraviani Williamson D Turner Joshua D Wythe Jason E Fish Sara S Nunes Source Type: research

ASAP Effect of Tetrahedral Framework Nucleic Acids on Neurological Recovery via Ameliorating Apoptosis and Regulating the Activation and Polarization of Astrocytes in Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c10364
Source: ACS Applied Materials and Interfaces - August 11, 2022 Category: Materials Science Authors: Mi Zhou, Tianxu Zhang, Xiaolin Zhang, Mei Zhang, Shaojingya Gao, Tao Zhang, Songhang Li, Xiaoxiao Cai, Jun Li, and Yunfeng Lin Source Type: research

ASAP Neutrophil-Biomimetic “Nanobuffer” for Remodeling the Microenvironment in the Infarct Core and Protecting Neurons in the Penumbra via Neutralization of Detrimental Factors to Treat Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c09020
Source: ACS Applied Materials and Interfaces - June 13, 2022 Category: Materials Science Authors: Shanshan Liu, Jianpei Xu, Yipu Liu, Yang You, Laozhi Xie, Shiqiang Tong, Yu Chen, Kaifan Liang, Songlei Zhou, Fengan Li, Zhuang Tang, Ni Mei, Huiping Lu, Xiaolin Wang, Xiaoling Gao, and Jun Chen Source Type: research

Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, and NINDS (National Institute of Neurological Disorders and Stroke) Early Phase Pain Investigation Clinical Network (EPPIC-Net) Provides Robust Infrastructure for Clinical Trials of Non-addictive Pain Therapeutics
We present EPPIC-Net's accomplishments since opening in Q4 of 2019. In its first year, EPPIC-Net established a robust infrastructure including a Clinical Coordinating Center, Data Coordinating Center, and 12 Specialized Clinical Centers across th e US, providing broad outreach to diverse pain populations.
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Barbara Karp, Rebecca Hommer, Marlene Peters Lawrence, Jennifer H. Barnes, Clinton B. Wright Tags: Clinical Trials for Pain Research121 Source Type: research

NIH HEAL Initiative: National Institute of Neurological Disorders and Stroke Preclinical Program for Non-Addictive Pain Therapeutic Development
The National Institutes of Health Helping to End Addiction Long-term, or NIH HEAL Initiative aims to focus efforts on advancing scientific solutions to stem the opioid crisis, improving prevention and treatment of opioid misuse/addiction, and enhancing pain management. NINDS is charged with accelerating the discovery and development of new non-addictive pharmacologic and non-pharmacologic pain therapeutics as part of the HEAL Initiative. PSPP provides researchers from academia and industry, within the US and internationally, an efficient, rigorous, one-stop in vivo resource to screen and profile therapeutic candidates incl...
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Sarah Woller, Smriti Iyengar Tags: 107 Source Type: research

Mapping the acute time course of immune cell infiltration into an ECM hydrogel in a rat model of stroke using 19 F MRI
Biomaterials. 2022 Jan 25;282:121386. doi: 10.1016/j.biomaterials.2022.121386. Online ahead of print.ABSTRACTExtracellular matrix (ECM) hydrogel implantation into a stroke-induced tissue cavity invokes a robust cellular immune response. However, the spatio-temporal dynamics of immune cell infiltration into peri-infarct brain tissues versus the ECM-bioscaffold remain poorly understood. We here tagged peripheral immune cells using perfluorocarbon (PFC) nanoemulsions that afford their visualization by 19F magnetic resonance imaging (MRI). Prior to ECM hydrogel implantation, only blood vessels could be detected using 19F MRI. ...
Source: Biomaterials - January 30, 2022 Category: Materials Science Authors: Michel Modo Harmanvir Ghuman Reem Azar Ryan Krafty Stephen F Badylak T Kevin Hitchens Source Type: research

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