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Total 154 results found since Jan 2013.
Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes
Biomaterials. 2023 Aug 15;301:122277. doi: 10.1016/j.biomaterials.2023.122277. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) remains the most lethal type of stroke, and effective clinical therapies that can speed up hematoma resolution after ICH are still lacking. While the beneficial effects of IL-10 on ICH recovery have been demonstrated, the clinical translation of IL-10 requires effective delivery methods by which sufficient IL-10 can be delivered to ICH-affected regions in the brain. Here we report the use of a phosphatidylserine (PS) liposome (PSL)-based nanoparticle system for microglia/macrophage-tar...
Source: Biomaterials - August 19, 2023 Category: Materials Science Authors: Ranran Han Xi Lan Zheng Han Honglei Ren Safiya Aafreen Wenshen Wang Zhipeng Hou Tianyue Zhu Andrew Qian Xiaoning Han Raymond C Koehler Guanshu Liu Source Type: research
Development of predictive algorithms for the wear resistance of denture teeth materials
CONCLUSIONS: 3D printed denture teeth materials showed the lowest wear out of all studied for 48 months simulation. LSTM model was successfully developed to predict wear of various denture teeth. The developed LSTM model has the potential to reduce simulation duration and specimen number for wear testing of various dental materials, while potentially improving the accuracy and reliability of wear testing predictions. This work paves the way for generalized multi-sample models enhanced with empirical information.PMID:37392604 | DOI:10.1016/j.jmbbm.2023.105984
Source: Journal of the Mechanical Behavior of Biomedical Materials - July 1, 2023 Category: Materials Science Authors: Anastasiia Grymak Mei Ting Tieh Alexander Hui Xiang Yang Joanne Jung Eun Choi Source Type: research
The potential role of the novel orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and the combined extract of holy basil and ginger for the management of stroke with stress
In this study, we explored the neuroprotective effect of an orodispersible film derived from a rice polymer loaded with silkworm pupae and the combined extract of holy basil and ginger (JP1). Male Wistar rats weighing 200-250 g were administered JP1 at the doses of 1, 10, and 100 mg/kg BW 45 min prior to an exposure to a 6-h immobilization stress for 14 days. Permanent, occlusion of the right middle cerebral artery (MCAO) was performed, and JP1 was administered continually for 21 days after MCAO. Assessments of the brain infarction volume, oxidative stress, inflammation, and apoptosis in the cerebral cortex were carried ou...
Source: Biomaterials - June 1, 2023 Category: Materials Science Authors: Putthiwat Thongwong Jintanaporn Wattanathorn Wipawee Thukhammee Somsak Tiamkao Source Type: research
A new insight into the mechanical properties of nanobiofibers and vibrational behavior of atomic force microscope beam considering them as the samples
J Mech Behav Biomed Mater. 2023 Apr 5;142:105842. doi: 10.1016/j.jmbbm.2023.105842. Online ahead of print.ABSTRACTNowadays, the utilization and production of polymeric nanofibers are expanding rapidly due to their unique and exclusive properties. The current study examined silk fibroin nanofibers, poly-L lactic acid (PLLA), and polycaprolactone (PCL) as three widely-used biopolymers. In the first section, the mechanical properties of nanobiofibers, including elastic modulus as the first research variable, were investigated using atomic force microscopy (AFM)-based nanoindentation and tensile testing (through a universal te...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 9, 2023 Category: Materials Science Authors: Ali Jafari Ali Sadeghi Source Type: research
The influence of blood composition and loading frequency on the behavior of embolus analogs
J Mech Behav Biomed Mater. 2023 Feb 18;140:105738. doi: 10.1016/j.jmbbm.2023.105738. Online ahead of print.ABSTRACTIn cases of acute ischemic stroke (AIS), mechanical thrombectomy (MT) can be used to directly remove lodged thromboemboli. Despite improvements in patient outcomes, one of the key factors affecting MT success is the mechanical properties of the occlusive thrombus. Therefore, the goal of this study was to investigate the viscoelastic properties of embolus analogs (EAs) and determine the influence of EA hematocrit and loading frequency. Bovine blood EAs were created over a range of physiological hematocrits (0-6...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 23, 2023 Category: Materials Science Authors: Bryan C Good Source Type: research
Is the optimal Tmax threshold identifying perfusion deficit volumes variable across MR perfusion software packages? A pilot study
ConclusionsThe optimal Tmax threshold for defining the ischemic penumbra appeared to be most accurate at ≥ 6 s for package A and ≥ 10 s for package B. This implies that the widely recommended Tmax threshold ≥ 6 s may not be optimal for all available MRP software package. Future validation studies are required to define the optimal Tmax threshold to use for each package.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - February 22, 2023 Category: Materials Science Source Type: research
Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane
Biomaterials. 2022 Dec 23;293:121983. doi: 10.1016/j.biomaterials.2022.121983. Online ahead of print.ABSTRACTThe basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix (ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial roles in regulating the unique physiological barrier function of the BBB, which represents a major obstacle for brain drug delivery. Owing to the difficulty in mimicking the unique biophysical and chemical features of BM in in vitro systems, current in vitro BBB models have suffered from poor physiological relevance. Here, we describe a highl...
Source: Biomaterials - January 7, 2023 Category: Materials Science Authors: Jeong-Won Choi Jaeseung Youn Dong Sung Kim Tae-Eun Park Source Type: research
A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure
CONCLUSIONS: The surrogate model provides nearly instantaneous estimates and constitutes a valuable tool for evaluating the risk of thrombus rupture during pre-operative planning for the treatment of acute ischemic stroke.PMID:36410165 | DOI:10.1016/j.jmbbm.2022.105577
Source: Journal of the Mechanical Behavior of Biomedical Materials - November 21, 2022 Category: Materials Science Authors: Sara Bridio Giulia Luraghi Francesco Migliavacca Sanjay Pant Alberto Garc ía-González Jose F Rodriguez Matas Source Type: research
Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
Biomaterials. 2022 Nov 10;291:121904. doi: 10.1016/j.biomaterials.2022.121904. Online ahead of print.ABSTRACTOxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3-n-butylphthalide (NBP-CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochond...
Source: Biomaterials - November 20, 2022 Category: Materials Science Authors: Xiang Li Zhihui Han Tianyi Wang Cheng Ma Haiying Li Huali Lei Yuqi Yang Yuanjie Wang Zifan Pei Zhuang Liu Liang Cheng Gang Chen Source Type: research
