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Specialty: Neuroscience
Condition: Spinal Cord Injury
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Total 97 results found since Jan 2013.
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation
Rehabilitation approaches for individuals with neurologic conditions have increasingly shifted toward promoting neuroplasticity for enhanced recovery and restoration of function. This review focuses on exercise strategies and non-invasive neuromodulation techniques that target neuroplasticity, including transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), and peripheral nerve stimulation (PNS). We have chosen to focus on non-invasive neuromodulation techniques due to their greater potential for integration into routine clinical practice. We explore and discuss the application of these interventional stra...
Source: Frontiers in Human Neuroscience - July 21, 2023 Category: Neuroscience Source Type: research
Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems
We describe the recently discovered functions of Hv1 in various neurological diseases, including brain or spinal cord injury, ischemic stroke, demyelinating diseases, and pain. We also summarize the current advances in the discovery and application of Hv1-targeted small molecules in neurological diseases. Finally, we discuss the current limitations of our understanding of Hv1 and suggest future research directions.
Source: Neuroscience Bulletin - April 8, 2023 Category: Neuroscience Source Type: research
Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition
CONCLUSION: Our results suggest that Tregs promote functional recovery after SCI by alleviating microglia inflammatory reaction via STAT3.PMID:36914969 | DOI:10.1111/cns.14161
Source: CNS Neuroscience and Therapeutics - March 14, 2023 Category: Neuroscience Authors: Rui Liu Ying Li Ziyue Wang Peng Chen Yi Xie Wensheng Qu Minghuan Wang Zhiyuan Yu Xiang Luo Source Type: research
Neuroprotective Roles of Apelin-13 in Neurological Diseases
This study summarizes the pathophysiological roles of apelin-13 in the development and progression of neurological related diseases.PMID:36745269 | DOI:10.1007/s11064-023-03869-0
Source: Neurochemical Research - February 6, 2023 Category: Neuroscience Authors: Yang Zhang Weiwei Jiang Wenjie Sun Weiming Guo Beibei Xia Xiangru Shen Mingyuan Fu Teng Wan Mei Yuan Source Type: research
Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders
AbstractThe concept of the glial-vascular unit (GVU) was raised recently to emphasize the close associations between brain cells and cerebral vessels, and their coordinated reactions to diverse neurological insults from a “glio-centric” view. GVU is a multicellular structure composed of glial cells, perivascular cells, and perivascular space. Each component is closely linked, collectively forming the GVU. The central roles of glial and perivascular cells and their multi-level interconnections in the GVU under nor mal conditions and in central nervous system (CNS) disorders have not been elucidated in detail. Here, we c...
Source: Neuroscience Bulletin - November 14, 2022 Category: Neuroscience Source Type: research
Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery
AbstractCentral nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord injury, are leading causes of long-term disability. It is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated limb. Previous studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote recovery. However, the ability to increase plasticity in the injured brain is restricted and difficult to improve. Therefore, over several decades, researchers have been prompted to enhance the compensati...
Source: Neuroscience Bulletin - November 4, 2022 Category: Neuroscience Source Type: research
Changes in corticospinal and spinal reflex excitability through functional electrical stimulation with and without observation and imagination of walking
Functional electrical stimulation (FES), a method for inducing muscle contraction, has been successfully used in gait rehabilitation for patients with deficits after neurological disorders and several clinical studies have found that it can improve gait function after stroke and spinal cord injury. However, FES gait training is not suitable for patients with walking difficulty, such as those with severe motor paralysis of the lower limbs. We have previously shown that action observation combined with motor imagery (AO + MI) of walking induces walking-related cortical activity. Therefore, we combined FES, which alternately ...
Source: Frontiers in Human Neuroscience - September 26, 2022 Category: Neuroscience Source Type: research
The effects of robot-assisted gait training combined with non-invasive brain stimulation on lower limb function in patients with stroke and spinal cord injury: A systematic review and meta-analysis
ConclusionThis meta-analysis demonstrated that RAGT therapy in combination with NIBS was effective in patients with stroke and SCI. However, a greater improvement in lower limb function and activities were not observed using RAGT with tDCS compared to sham stimulation.
Source: Frontiers in Human Neuroscience - August 16, 2022 Category: Neuroscience Source Type: research
Poststroke arm and hand paresis: should we target the cervical spinal cord?
Trends Neurosci. 2022 May 31:S0166-2236(22)00096-0. doi: 10.1016/j.tins.2022.05.002. Online ahead of print.ABSTRACTDespite advances in understanding of corticospinal motor control and stroke pathophysiology, current rehabilitation therapies for poststroke upper limb paresis have limited efficacy at the level of impairment. To address this problem, we make the conceptual case for a new treatment approach. We first summarize current understanding of motor control deficits in the arm and hand after stroke and their shared physiological mechanisms with spinal cord injury (SCI). We then review studies of spinal cord stimulation...
Source: Trends in Neurosciences - June 6, 2022 Category: Neuroscience Authors: Elvira Pirondini Erick Carranza Josep-Maria Balaguer Erynn Sorensen Douglas J Weber John W Krakauer Marco Capogrosso Source Type: research
Application of the Gait Deviation Index to Study Gait Impairment in Adult Population With Spinal Cord Injury: Comparison With the Walking Index for Spinal Cord Injury Levels
The Gait Deviation Index (GDI) is a multivariate measure of overall gait pathology based on 15 gait features derived from three-dimensional (3D) kinematic data. GDI aims at providing a comprehensive, easy to interpret, and clinically meaningful metric of overall gait function. It has been used as an outcome measure to study gait in several conditions: cerebral palsy (CP), post-stroke hemiparetic gait, Duchenne muscular dystrophy, and Parkinson’s disease, among others. Nevertheless, its use in population with Spinal Cord Injury (SCI) has not been studied yet. The aim of the present study was to investigate the applicabili...
Source: Frontiers in Human Neuroscience - April 4, 2022 Category: Neuroscience Source Type: research
