Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems

We describe the recently discovered functions of Hv1 in various neurological diseases, including brain or spinal cord injury, ischemic stroke, demyelinating diseases, and pain. We also summarize the current advances in the discovery and application of Hv1-targeted small molecules in neurological diseases. Finally, we discuss the current limitations of our understanding of Hv1 and suggest future research directions.
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research