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Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection
Conclusion: The present study suggests that lesion patterns observed from DWI of patients with PFO and SIAD might provide clues to the etiology of infarcts. Single lesions (cortical or subcortical) might be a typical feature of PFO associated strokes, while multiple lesions in one vascular territory might be a specific feature of SIAD associated strokes. Introduction Both patent foramen ovale (PFO) and spontaneous intracranial artery dissection (SIAD) are important stroke risk factors, especially in young and middle-aged adults (1–3). About 25% of patients with ischemic stroke are cryptogenic (4), and PFO is ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Perioperative stroke in patients undergoing elective spinal surgery: a retrospective analysis using the Japanese diagnosis procedure combination database
Conclusions: Perioperative stroke occurred in 0.22 % of patients undergoing spinal surgery. Resection of a spinal cord tumor was associated with increased risk of perioperative stroke as well as advanced age, comorbidities at admission, cervical spine surgery, surgery in a teaching hospital, and length of stay.
Source: BMC Musculoskeletal Disorders - October 2, 2015 Category: Orthopaedics Authors: Junichi OhyaHirotaka ChikudaTakeshi OichiHiromasa HoriguchiKatsushi TakeshitaSakae TanakaHideo Yasunaga Source Type: research

Differential Risk Factors and Outcomes of Ischemic Stroke due to Cervical Artery Dissection in Young Adults
Conclusions: While history of migraine and neck manipulation are significantly associated with CeAD, most of the traditional vascular risk factors for stroke are less prevalent in this group when compared to strokes due to other etiologies. For CeAD-related strokes, higher initial stroke severity and history of tobacco use may be associated with higher stroke-related disability, but overall, patients with CeAD have similar outcomes as compared to strokes due to other etiologies.Cerebrovasc Dis
Source: Cerebrovascular Diseases - September 25, 2020 Category: Neurology Source Type: research

Ischemic Stroke in Pregnancy and Postpartum: A Descriptive Case Series (P1.079)
CONCLUSIONS: In our series of 19 pregnancy-associated ischemic strokes, mechanisms appeared unrelated to traditional vascular risk factors, and there was a substantial proportion of poor outcomes. Strokes were commonest in the 12 weeks postpartum, almost one third of which occurred following a miscarriage. Further exploration with a larger cohort is planned.Disclosure: Dr. Miller has nothing to disclose. Dr. Yaghi has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. Willey has nothing to disclose. Dr. Elkind has received personal compensation for activities with BMS-Pfizer Partnership, Janssen Pharmaceuticals, ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Miller, E., Yaghi, S., Boehme, A., Willey, J., Elkind, M., Marshall, R. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

E-092 Use of balloon-guide catheters for concomitant mechanical thrombectomy and carotid revascularization with flow-arrest results in significantly lower sICH and better 90-day outcomes in tandem stroke patients
ConclusionUse of balloon-guide catheters for concomitant mechanical thrombectomy and carotid revascularization with flow-arrest results in significantly lower sICH and better 90-day outcomes in tandem stroke patients.Disclosures A. Baig: None. J. Neumaier: None. M. Waqas: None. A. Monteiro: None. J. Cappuzzo: None. W. Khawar: None. B. Donnelly: None. E. Levy: 2; C; : Claret Medical, GLG Consulting, Guidepoint Global, Imperial Care, Medtronic, Rebound, StimMed, Misionix, Mosiac, Clarion, IRRAS. 4; C; NeXtGen Biologics, RAPID Medical, Claret Medical, Cognition Medical, Imperative Care, Rebound Therapeutics, StimMed, Three Ri...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Baig, A., Neumaier, J., Waqas, M., Monteiro, A., Cappuzzo, J., Khawar, W., Donnelly, B., Levy, E., Siddiqui, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-108 Endovascular treatment of patients with acute ischemic stroke due to underlying arterial dissection: a nationwide analysis
ConclusionsDespite a similar prevalence among patients admitted for AIS, CA dissections are associated with a higher rate of endovascular intervention and poorer short-term outcomes compared to VA dissections. This study provides essential epidemiologic and outcome data for the cerebrovascular neurosurgeon.Abstract E-108 Table 1Comparison of clinical characteristics and outcomes among patients presenting with acute ischemic stroke due to carotid or vertebral artery dissections Characteristic Vertebral Artery Dissection, N = 2,562 Carotid Artery Dissection, N = 2,789 p-value1 Age (years), Mean (SD) 53 (17) 57 (17) <0.00...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Brandel, M., McCann, C., Wali, A., Wu, V., Esmail, S., Steinberg, J., Olson, S., Pannell, J., Khalessi, A., Santiago-Dieppa, D. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Unusual complication of vertebral arterial dissection
Discussion This patient had subacute onset of cervical cord infarction. The history and MRI findings were in keeping with cervical dissection. The vertebral artery is most vulnerable as it travels in the vertebral foramen and makes a curvature at C1–2 and dissection at this point usually causing cerebellar infarction and lateral medullary syndrome. A spinal cord infarct may occur if the extra–cranial vertebral artery is involved. Intracranial vertebral arterial dissection has a poor prognosis for neurological recovery but are usually not fatal. Extracranial VAD may cause spinal cord infarction but respiratory f...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Shanmugam, S., Pullicino, P., Strandvik, G. Tags: Brain stem / cerebellum, Neuroimaging, Neurological injury, Pain (neurology), Stroke, Trauma CNS / PNS, Ophthalmology, Trauma, Injury Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 Octob Source Type: research

036 A rare subtype of a rare type of stroke - sulcal artery syndrome
A 78 year old man was woken from sleep by a sudden excruciating neck pain. The pain was accompa- nied by left arm and leg weakness and paraesthesia which progressed to maximum intensity over hours. His past medical history was significant for ischaemic heart disease and type 2 diabetes. On examination there was an incomplete Brown-Sequard syndrome localising to the left hemicord. MRI of the cervical spine showed intramedullary T2 hyperintensity and restricted diffusion in the left hemicord at C2-C3 level. CT angiogram of the vertebral arteries excluded dissection. We diagnosed acute spinal cord infarction due to a sulcal a...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Win, M., Hernandez, A. C., Fox, R., Harikrishnan, S., McWilliam, M. Tags: Live Poster, 13 May Poster Session 1 Source Type: research

Cervical Artery Dissection in Patients of African Ancestry
Conclusion: AA patients represent a smaller proportion of CeAD cases compared to young stroke cases at our center. AA patients suffering CeAD have higher prevalence of both vascular risk factors and frequency of the CeAD risk allele compared to EA patients. These findings suggest a complex interplay between traditional vascular risk factors and genetic predisposition underlying CeAD pathogenesis. Further prospective research is needed to clarify these associations and disparities.Cerebrovasc Dis 2018;46:218 –222
Source: Cerebrovascular Diseases - December 5, 2018 Category: Neurology Source Type: research

E-049 Accuracy of non-invasive and invasive imaging in identifying ica occlusion: a comparative study in 65 patients
Conclusion Our result suggests that there is a lack of correlation between the imaging findings of carotid occlusion on imaging compared with catheter angiography of the ICA during the intervention in acute stroke treatment. Thus, endovascular catheterization of the ICA is often required for the exact characterization and localization of the carotid occlusion and to determine if a dissection is the underlying pathology in such cases. Disclosures A. El Mekabaty: None. Q. Hao: None. E. Cheng-Ching: None. S. Hussain: None. A. Spiotta: None. F. Hui: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Mekabaty, E., Hao, Q., Cheng-Ching, E., Hussain, S., Spiotta, A., Hui, F. Tags: Electronic Poster Abstracts Source Type: research

Spontaneous cervical artery dissection is accompanied by a hypercoagulable state and simultaneous inflammatory condition
ConclusionWe found evidence for a hypercoagulable state in patients with sCAD as indicated by a shortened aPTT, which was associated with a trend to an increased leucocyte count at the same time. Our findings first strengthen the hypothesis that inflammation critically impacts on the occurrence of sCAD, and second linked this condition with a marked affection of the coagulation system.
Source: Journal of Neurology - December 9, 2017 Category: Neurology Source Type: research