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The lncRNA MALAT1 rs619586 G Variant Confers Decreased Susceptibility to Recurrent Miscarriage
In conclusion, our study suggests that the rs619586 G variant may have potential protective effects conferring a decreased risk of recurrent miscarriage in the southern Chinese population. Introduction Recurrent miscarriage is defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation (Jaslow et al., 2010; Diejomaoh, 2015). The occurrence of recurrent miscarriage is associated with many factors, including genetic factors, immunological dysfunction, endocrine disorders, unhealthy lifestyles and defects of the reproductive organs (Saravelos and Regan, 2014; Sen et al., 2014; Garrido-Gimen...
Source: Frontiers in Physiology - April 8, 2019 Category: Physiology Source Type: research

Defining Sickle Cell Disease Severity Among Adults Hospitalized with Vaso-Occlusive Crisis
Conclusions: The high severity scores among this cohort supports the validity of employing a medical history checklist as a measure of disease severity, reflecting the cumulative end organ damage due to SCD and near universal need for daily pain medication among patients requiring inpatient admission for VOC. Two-thirds of patients were categorized as having high disease severity, driven primarily by daily pain medication use prior to hospitalization and pulmonary complications, consistent with a known subgroup of adults with SCD-related complications who are more likely to have lower health-related quality of life and acc...
Source: Blood - November 21, 2018 Category: Hematology Authors: Esham, K. S., Rodday, A. M., Savidge, N., Mao, D., Weidner, R. A., Parsons, S. K. Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster II Source Type: research

Vascular complications after balloon aortic valvuloplasty in recent years: Incidence and comparison of two hemostatic devices
ConclusionsVC rate after BAV is fairly low in experienced centers without major differences between the 2 most used VCD.
Source: Catheterization and Cardiovascular Interventions - October 5, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Gianni Dall'Ara, Andrea Santarelli, Antonio Marzocchi, Maria Letizia Bacchi Reggiani, Maria Rita Sabattini, Carolina Moretti, Cinzia Marrozzini, Nevio Taglieri, Federica Baldazzi, Nicoletta Franco, Paolo Ortolani, Matteo Chiarabelli, Giulio Rodin ò, Gian Tags: VALVULAR AND STRUCTURAL HEART DISEASES Source Type: research

Association Between Blood Transfusions and 12-Month Mortality After Transcatheter Aortic Valve Implantation.
In conclusion, blood transfusions after TAVI were associated with higher mortality rates after 12 months, longer in-hospital stay, and were identified as an independent predictor of impaired clinical outcome. PMID: 28077819 [PubMed - as supplied by publisher]
Source: International Heart Journal - January 14, 2017 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of Four Bleeding Risk Scores to Identify Rivaroxaban‐treated Patients With Venous Thromboembolism at Low Risk for Major Bleeding
ConclusionsFour scoring systems that use criteria obtained in routine clinical practice, derived to predict low bleeding risk with VKA treatment for VTE, identified patients with less than a 1% risk of major bleeding during full‐course treatment with rivaroxaban.
Source: Academic Emergency Medicine - January 14, 2016 Category: Emergency Medicine Authors: Jeffrey A. Kline, David Jimenez, D. Mark Courtney, Juliana Ianus, Lynn Cao, Anthonie W.A. Lensing, Martin H. Prins, Philip S. Wells Tags: Original Contribution Source Type: research

Perioperative stroke in patients undergoing elective spinal surgery: a retrospective analysis using the Japanese diagnosis procedure combination database
Conclusions: Perioperative stroke occurred in 0.22 % of patients undergoing spinal surgery. Resection of a spinal cord tumor was associated with increased risk of perioperative stroke as well as advanced age, comorbidities at admission, cervical spine surgery, surgery in a teaching hospital, and length of stay.
Source: BMC Musculoskeletal Disorders - October 2, 2015 Category: Orthopaedics Authors: Junichi OhyaHirotaka ChikudaTakeshi OichiHiromasa HoriguchiKatsushi TakeshitaSakae TanakaHideo Yasunaga Source Type: research

Comparison of Hybrid Coronary Revascularization Versus Coronary Artery Bypass Grafting in Patients ≥65 Years With Multivessel Coronary Artery Disease
In this study, patients aged ≥65 years were included who underwent HCR at an academic center from October 2003 to September 2013. These patients were matched 1:4 to similar patients treated with coronary artery bypass grafting (CABG) using a propensity-score matching algorithm. Conditional logistic regression and Cox regression stratified on matched pairs were performed to evaluate the association between HCR and CABG, and 30-day major adverse cardiovascular and cerebrovascular events (a composite of mortality, myocardial infarction, and stroke), periprocedural complications, and 3-year all-cause mortality. Of 715 patien...
Source: The American Journal of Cardiology - May 5, 2014 Category: Cardiology Authors: Ralf E. Harskamp, John D. Puskas, Jan G. Tijssen, Patrick F. Walker, Henry A. Liberman, Renato D. Lopes, Thomas A. Vassiliades, Eric D. Peterson, Michael E. Halkos Tags: Coronary Artery Disease Source Type: research

Modeling anesthetic times. Predictors and implications for short-term outcomes
Conclusions: Modeling individually anesthetic induction and recovery time on the basis of operative and anesthetic procedure characteristics is feasible. Anesthetic and operative times do not impact perioperative morbidity and mortality.
Source: Journal of Surgical Research - October 31, 2012 Category: Surgery Authors: Panagiotis Kougias, Vikram Tiwari, Neal R. Barshes, Carlos F. Bechara, Briauna Lowery, George Pisimisis, David H. Berger Tags: Association for Academic Surgery Source Type: research