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Hypoxic postconditioning drives protective microglial responses and ameliorates white matter injury after ischemic stroke
CONCLUSION: HPC promotes protective microglial responses and white matter repair after MCAO, which may be related to the proliferation and differentiation of oligodendrocytes.PMID:37435771 | DOI:10.1111/cns.14346
Source: CNS Neuroscience and Therapeutics - July 12, 2023 Category: Neuroscience Authors: Wei Zhang Sijie Li Ho Jun Yun Wantong Yu Wenjie Shi Chen Gao Jun Xu Yu Yang Linhui Qin Yuchuan Ding Kunlin Jin Fengyong Liu Xunming Ji Changhong Ren Source Type: research

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke
AbstractPurpose of ReviewThis review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury.Recent FindingsNeuroinflammation is a crucial process following acute ischemic stroke (AIS) and hemorrhagic stroke (HS). In AIS, neuroinflammation is initiated within minutes of the ischemia onset and continues for several days. In HS, neuroinflammation is initiated by blood byproducts in the subarachnoid space and/or brain parenchyma. In both cases, neuroinflammation is characterized b...
Source: Current Neurology and Neuroscience Reports - July 3, 2023 Category: Neuroscience Source Type: research

Astrocyte-Neuronal Communication and Its Role in Stroke
Neurochem Res. 2023 Jun 17. doi: 10.1007/s11064-023-03966-0. Online ahead of print.ABSTRACTAstrocytes are the most abundant glial cells in the central nervous system. These cells are an important hub for intercellular communication. They participate in various pathophysiological processes, including synaptogenesis, metabolic transformation, scar production, and blood-brain barrier repair. The mechanisms and functional consequences of astrocyte-neuron signaling are more complex than previously thought. Stroke is a disease associated with neurons in which astrocytes also play an important role. Astrocytes respond to the alte...
Source: Neurochemical Research - June 17, 2023 Category: Neuroscience Authors: Zi-Meng Yao Xiao-Rong Sun Jie Huang Lei Chen Shu-Ying Dong Source Type: research

Epigenetics and stroke: role of DNA methylation and effect of aging on blood –brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptiona l profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven day s poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11,287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in gen...
Source: Fluids and Barriers of the CNS - February 28, 2023 Category: Neuroscience Source Type: research

Metformin enhances neural precursor cells migration and functional recovery after ischemic stroke in mice
Exp Brain Res. 2023 Jan 8. doi: 10.1007/s00221-023-06547-3. Online ahead of print.ABSTRACTResident neural precursor cells (NPCs) activation is a promising therapeutic strategy for brain repair. This strategy involves stimulating multiple stages of NPCs development, including proliferation, self-renewal, migration, and differentiation. Metformin, an FDA-approved diabetes drug, has been shown to promote the proliferation and differentiation of NPCs. However, it is still unclear whether metformin promotes the migration of NPCs. EVOS living cell imaging system was used for observing the migration for primary NPCs dynamically i...
Source: Experimental Brain Research - January 7, 2023 Category: Neuroscience Authors: Liang Zhang Jing Zhang Xiaoming Zhu Wei Jiao Yang Yang Youping Wu Likun Yang Yuhai Wang Source Type: research

A review of remote ischemic conditioning as a potential strategy for neural repair poststroke
CNS Neurosci Ther. 2022 Dec 22. doi: 10.1111/cns.14064. Online ahead of print.ABSTRACTIschemic stroke is one of the major disabling health-care problem and multiple different approaches are needed to enhance rehabilitation, in which neural repair is the structural basement. Remote ischemic conditioning (RIC) is a strategy to trigger endogenous protect. RIC has been reported to play neuroprotective role in acute stage of stroke, but the effect of RIC on repair process remaining unclear. Several studies have discovered some overlapped mechanisms RIC and neural repair performs. This review provides a hypothesis that RIC is a ...
Source: CNS Neuroscience and Therapeutics - December 22, 2022 Category: Neuroscience Authors: Wantong Yu Changhong Ren Xunming Ji Source Type: research

Predictors of Time to Aneurysm Repair and Mortality in Aneurysmal Subarachnoid Hemorrhage
CONCLUSION: Our results indicate that treatment at a CSC was associated with a lower risk of in-hospital mortality. Time to aneurysm repair did not influence mortality and did not explain the mortality benefit observed in CSCs. Research is needed to explore interdisciplinary hospital factors including nursing and nurse-sensitive interventions that may explain the relationship between CSCs and mortality outcomes.
Source: Journal of Neuroscience Nursing - September 10, 2022 Category: Neuroscience Tags: Articles Source Type: research

Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1 α/VEGF signaling pathway in experimental stroke
CONCLUSIONS: Zinc significantly improves neurological function recovery during the cerebral ischemia repair stage, providing new evidence supporting zinc as a potential therapeutic target for ischemic stroke by promoting astrocyte induced angiogenesis.PMID:35855611 | DOI:10.1111/cns.13918
Source: CNS Neuroscience and Therapeutics - July 20, 2022 Category: Neuroscience Authors: Yang Li Tingting Ma Xiaoyu Zhu Mingqi Zhang Liang Zhao Peng Wang Jia Liang Source Type: research

Phagocytic microglia and macrophages in brain injury and repair
CONCLUSION: Identification of biological targets that can temper neuroinflammation after brain injury without hindering the essential phagocytic functions of microglia/macrophages will expedite better medical management of the stroke recovery stage.PMID:35751629 | DOI:10.1111/cns.13899
Source: CNS Neuroscience and Therapeutics - June 25, 2022 Category: Neuroscience Authors: Fang Yu Yangfan Wang Anne R Stetler Rehana K Leak Xiaoming Hu Jun Chen Source Type: research

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