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Specialty: Respiratory Medicine
Procedure: Lung Transplant

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Total 16 results found since Jan 2013.

The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: A translational porcine model
In conclusion, we demonstrate a delicate balance between development of pulmonary ischemia-reperfusion injury and right ventricular function during lung transplantation. Furthermore, we provide a physiological basis for potential benefit of extracorporeal life support technology.PMID:37724349 | DOI:10.1152/ajplung.00281.2022
Source: Am J Physiol Lung Ce... - September 19, 2023 Category: Respiratory Medicine Authors: Michaela Orlitov á Tom Verbelen Anna E Frick Arno Vanstapel Dieter Van Beersel Sofie Ordies Jan Van Slambrouck Janne Kaes Jin Xin Walter Coudyzer Stijn E Verleden Geert M Verleden Bart M Vanaudenaerde Dirk E Van Raemdonck Robin Vos Laurens J Ceulemans Pi Source Type: research

National Trends, Risk Factors, and Outcomes of Acute In-hospital Stroke After Lung Transplantation in the United States: Analysis of the United Network for Organ Sharing Registry
Chest. 2023 Apr 11:S0012-3692(23)00503-2. doi: 10.1016/j.chest.2023.04.007. Online ahead of print.ABSTRACTBACKGROUND: Lung transplantation is the definitive treatment for end-stage lung failure. However, there have been no large, long-term studies on the impact of acute in-hospital stroke in this population.RESEARCH QUESTION: What are the trends, risk factors, and outcomes of acute stroke in patients undergoing lung transplantation in the United States?STUDY DESIGN AND METHODS: We identified adult first-time, isolated lung transplant (LTx) recipients from the United Network for Organ Sharing (UNOS) database, which comprehe...
Source: Chest - April 13, 2023 Category: Respiratory Medicine Authors: Benjamin L Shou Christopher Wilcox Isabella Florissi Aravind Krishnan Bo Soo Kim Steven P Keller Glenn J R Whitman Ken Uchino Errol L Bush Sung-Min Cho Source Type: research

Postoperative management of lung transplant recipients.
Authors: Kao CC, Parulekar AD Abstract Despite advances in surgical technique, lung transplantation is associated with worse survival when compared with other solid organ transplantations. Graft dysfunction and infection are the leading causes of mortality in the first 30 days following transplantation. Primary graft dysfunction (PGD) is a form of reperfusion injury that occurs early after transplantation. Management of PGD is mainly supportive with use of lung protective ventilation. Inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation may be used in severe cases. Bacterial pneumonias are the most co...
Source: Journal of Thoracic Disease - October 23, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The value of Stanford integrated psychosocial assessment for transplantation (SIPAT) in prediction of clinical outcomes following left ventricular assist device (LVAD) implantation
ConclusionIn this single-center retrospective study, SIPAT did not predict cumulative re-admissions. Further study is required to validate SIPAT before clinical implementation.
Source: Heart and Lung: The Journal of Acute and Critical Care - September 16, 2018 Category: Respiratory Medicine Source Type: research

Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study
Publication date: Available online 9 April 2018 Source:The Lancet Respiratory Medicine Author(s): Gregor Warnecke, Dirk Van Raemdonck, Michael A Smith, Gilbert Massard, Jasleen Kukreja, Federico Rea, Gabriel Loor, Fabio De Robertis, Jayan Nagendran, Kumud K Dhital, Francisco Javier Moradiellos Díez, Christoph Knosalla, Christian A Bermudez, Steven Tsui, Kenneth McCurry, I-Wen Wang, Tobias Deuse, Guy Lesèche, Pascal Thomas, Igor Tudorache, Christian Kühn, Murat Avsar, Bettina Wiegmann, Wiebke Sommer, Arne Neyrinck, Marco Schiavon, Fiorella Calebrese, Nichola Santelmo, Anne Olland, Pierre-Emanuel Falcoz, Andre R Simon, A...
Source: The Lancet Respiratory Medicine - April 10, 2018 Category: Respiratory Medicine Source Type: research

Comparison of a portable device versus a specific spirometer for cough flow testing
Conclusions: In this evaluation, including patients with heterogeneous disorders and normal controls, CPF readings were on average significantly higher when measured using the equipment with the CPF testing dedicated software; moreover this device allows for a better assessment of the cough maneuvers including visualization of the cough flow-volume loops.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Maia Silva, A., Viamonte, S., Machado Vaz, I., Almeida, M., Gomes, A., Silva, F., Winck, J. C. Tags: Monitoring Airway Disease Source Type: research

Prognostic value of hemodynamics following treatment initiation in pulmonary arterial hypertension
Conclusions: Stroke volume index and right atrial pressure at first follow-up catheterization were the best hemodynamic predictors of death or transplantation. These variables should be further validated as treatment targets in a prospective study.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Weatherald, J., Adir, Y., Boucly, A., Savale, L., Simonneau, G., Montani, D., Jaïs, X., Humbert, M., Chemla, D., Sitbon, O., Herve, P. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation: A meta-analysis
Conclusion: ECMO support for LuTx showed better clinical outcomes compared to CPB.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Magouliotis, D., Svokos, A., Svokos, K., Olland, A., Massard, G., Tasiopoulou, V., Zacharoulis, D. Tags: Transplantation Source Type: research

Mortality, rehospitalization, and post-transplant complications in gender-mismatched heart transplant recipients
Conclusion Female HT recipients with male donors had worse 3-year outcomes as compared to male-mismatch and no-mismatch groups.
Source: Heart and Lung: The Journal of Acute and Critical Care - May 10, 2017 Category: Respiratory Medicine Source Type: research

Stroke and myocardial infarction following bronchial artery embolization in a cystic fibrosis patient
A 31year-old male with advanced CF lung disease (genotype F508del/R560T) presented with massive hemoptysis in the context of a pulmonary exacerbation. Baseline lung function showed a forced expiratory volume in 1s of 0.89L (22% predicted), and respiratory cultures consistently grew Pseudomonas aeruginosa and methicillin resistant Staphylococcus aureus. He was actively listed for lung transplant but was considered a high risk candidate, given right lung volume loss associated with pronounced mediastinal shift.
Source: Journal of Cystic Fibrosis - December 5, 2016 Category: Respiratory Medicine Authors: Matt Hoffman, Joseph P. Gerding, Jonathan B. Zuckerman Tags: Letter to the Editor Source Type: research

Clinical outcomes in overweight heart transplant recipients
Conclusions Overweight HT patients had better survival, but more rejections, CAV, and diabetes. Non-overweight HT patients had worse survival, plus more re-hospitalization time, lymphoma, and renal dysfunction.
Source: Heart and Lung: The Journal of Acute and Critical Care - April 23, 2016 Category: Respiratory Medicine Source Type: research

Cerebral air embolism during CT-guided lung biopsy
A patient with cirrhosis and hepatocellular carcinoma, on the waiting list for liver transplantation, presented with lung nodule during initial evaluation. A CT-guided core needle lung biopsy under general anaesthesia was performed. Pneumothorax (figure 1) and a large amount of gas within the left ventricle (figure 2) were identified during the procedure. Neurological focal signs (drowsiness, conjugate eye deviation and right hemiparesis) were observed in the anaesthesia-recovery period. A brain CT scan was immediately obtained, showing cerebral air embolism (figure 3). Initial resuscitation and hyperbaric oxygen therapy w...
Source: Thorax - October 14, 2015 Category: Respiratory Medicine Authors: Rocha, R. D., Azevedo, A. A., Falsarella, P. M., Rahal, A., Garcia, R. G. Tags: Images in Thorax, Journalology, Screening (oncology), Venous thromboembolism, Pulmonary embolism, Transplantation, Ethics Chest clinic Source Type: research

Transplants give Garden Plain man a second chance at life
Chris Simon’s bucket list wasn’t anything fancy. He simply wanted to be able to ride a bike again. Or take a swim. Or go camping with friends. “Stuff I used to do all the time,” Simon said. “And all of a sudden it was taken away.” Those once simple joys were stolen by cystic fibrosis, the same disease that claimed his younger sister Emily’s life in 2009. The Simon family on Sunday will join millions of others around the world in celebrating Easter, a day symbolizing new beginnings. The holiday will have special significance for Chris, 26, who has another chapter dawning in his life after a double-lung/liver t...
Source: Cystic Fibrosis Worldwide Blog - April 20, 2014 Category: Respiratory Medicine Authors: Webmaster Tags: Uncategorized Source Type: blogs

Changes in right heart haemodynamics and echocardiographic function in an advanced phenotype of pulmonary hypertension and right heart dysfunction associated with pulmonary fibrosis
Conclusions PH-targeted therapy may improve right heart haemodynamics and echocardiographic function without affecting systemic oxygen saturation in an advanced PH phenotype associated with RV dysfunction in the setting of PF.
Source: Thorax - January 15, 2014 Category: Respiratory Medicine Authors: Saggar, R., Khanna, D., Vaidya, A., Derhovanessian, A., Maranian, P., Duffy, E., Belperio, J. A., Weigt, S. S., Dua, S., Shapiro, S. S., Goldin, J. G., Abtin, F., Lynch, J. P., Ross, D. J., Forfia, P. R., Saggar, R. Tags: Health policy, Interstitial lung disease, Pulmonary hypertension, Cardiothoracic surgery, Transplantation, Health service research Pulmonary vasculature Source Type: research