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Bone marrow ‐derived myeloid progenitors in the leptomeninges of adult mice
This study identified a heterogeneous population of myeloid progenitors in the leptomeninges of adult mice, which gave rise to all major myelo ‐erythroid lineages in clonogenic assays. Lineage tracing and bone marrow transplantation showed that the progenitors were derived from adult hematopoietic stem cells and most likely continuously replaced via cell trafficking. Their numbers were diminished in the context of neuroinflammation. AbstractAlthough the bone marrow contains most hematopoietic activity during adulthood, hematopoietic stem and progenitor cells can be recovered from various extramedullary sites. Cells with ...
Source: Stem Cells - December 11, 2020 Category: Stem Cells Authors: Tobias Koeniger, Luisa Bell, Anika Mifka, Michael Enders, Valentin Hautmann, Subba Rao Mekala, Philipp Kirchner, Arif B. Ekici, Christian Schulz, Philipp W örsdörfer, Stine Mencl, Christoph Kleinschnitz, Süleyman Ergün, Stefanie Kuerten Tags: Tissue ‐Specific Stem Cells Source Type: research

Interleukin-1 receptor inhibition reduces stroke size in a murine model of sickle cell disease.
Abstract Sickle cell disease (SCD) is associated with chronic hemolytic anemia and a heightened inflammatory state. The causal role of inflammatory pathways in stroke associated with SCD is unclear. Therefore, the hypothesis that deletion of the non-hematopoietic interleukin-1 receptor (IL-1R) pool may be beneficial in SCD was pursued. Since potential deleterious effects of IL-1R signaling in SCD could be mediated via downstream production of interleukin-6 (IL-6), the role of the non-hematopoietic IL-6 pool was also addressed. Bone marrow transplantation (BMT) from SCD to wild-type (WT) recipient mice was used to ...
Source: Haematologica - August 12, 2020 Category: Hematology Authors: Venugopal J, Wang J, Mawri J, Guo C, Eitzman D Tags: Haematologica Source Type: research

Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required. Ethics Statement All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Com...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Cardiac Complications in the Adult Bone Marrow Transplant Patient
AbstractPurpose of ReviewDue to advancements in oncologic treatment strategies and techniques, the number of survivors who have undergone hematopoetic stem cell transplant (HCT) continues to increase in the United States; this number is projected to reach 502,000 by the year 2030. There is significant interest within the field of cardio-oncology to identify cardiotoxicity and cardiovascular disease in the HCT population. Epidemiologic studies analyzing both short- and long-term cardiovascular effects, risk stratification modeling, cardioprotective strategies, and expert consensus documents for cardiotoxicity surveillance r...
Source: Current Oncology Reports - March 1, 2019 Category: Cancer & Oncology Source Type: research

Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke
AbstractTreatment of acute ischemic stroke with the thrombolytic tissue plasminogen activator (tPA) can significantly improve neurological outcomes; however, thrombolytic therapy is associated with an increased risk of intra-cerebral hemorrhage (ICH). Previously, we demonstrated that during stroke tPA acting on the parenchymal side of the neurovascular unit (NVU) can increase blood –brain barrier (BBB) permeability and ICH through activation of latent platelet-derived growth factor-CC (PDGF-CC) and signaling by the PDGF receptor-α (PDGFRα). However, in vitro, activation of PDGF-CC by tPA is very inefficient and the mec...
Source: Acta Neuropathologica - July 19, 2017 Category: Neurology Source Type: research

Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation.
CONCLUSIONS: Plt-VWF, either in presence or absence of ADAMTS13, partially contributes to VWF-dependent injury and postischemic thrombo-inflammation after stroke. EC-VWF is the major determinant that mediates VWF-dependent ischemic stroke by promoting postischemic thrombo-inflammation. PMID: 27444201 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 20, 2016 Category: Cardiology Authors: Dhanesha N, Prakash P, Doddapattar P, Khanna I, Pollpeter MJ, Nayak MK, Staber JM, Chauhan AK Tags: Arterioscler Thromb Vasc Biol Source Type: research

Thiamine Deficiency While on Total Parenteral Nutrition Mimicking Acute Stroke: A Case Report (P3.217)
CONCLUSIONS: Thiamine deficiency mimicking stroke while on total parenteral nutrition has been rarely documented. Recognition of this syndrome is critical as prompt treatment may reverse symptoms.Disclosure: Dr. Parker has nothing to disclose. Dr. Marafie has nothing to disclose. Dr. Wolf has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Parker, A., Marafie, D., Wolf, V. Tags: Neurocritical Care: Clinical Science and Therapeutics Source Type: research

Migration of Bone Marrow‐Derived Cells Into the Central Nervous System in Models of Neurodegeneration
This study confirms that BMDC infiltrate the CNS in animal models for stroke and Alzheimer's disease and that peripheral cells can be targeted to treat affected regions of the CNS. J. Comp. Neurol. 521:3863–3876, 2013. © 2013 Wiley Periodicals, Inc.
Source: The Journal of Comparative Neurology - October 7, 2013 Category: Neurology Authors: Antoine Lampron, Pedro M. Pimentel‐Coelho, Serge Rivest Tags: Cover Image Source Type: research

Development of psychological and intellectual performance in transplanted sickle cell disease patients: A prospective study from pretransplant period to 5years after HSCT.
CONCLUSION: At the end of follow-up, the patients improved their physical and psychological well-being. This allowed them to build projects for the future and to manifest the desire of becoming an adult. Bone marrow transplantation in this cohort of children with SCD and severe cerebral vasculopathy is associated with improved performance as measured by the Wechsler scale. PMID: 23769628 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - June 11, 2013 Category: Pediatrics Authors: Bockenmeyer J, Chamboredon E, Missud F, Benkerrou M, Holvoët L, Ithier G, Lescoeur B, Yakouben K, Ouachée-Chardin M, Rohrlich PS, Duval M, Baruchel A, Dalle JH Tags: Arch Pediatr Source Type: research

Migration of bone marrow‐derived cells into the CNS in models of neurodegeneration
This study confirms that bone marrow‐derived cells infiltrate the CNS in animal models for stroke and Alzheimer's disease and that peripheral cells can be targeted to treat affected regions of the CNS. J. Comp. Neurol., 2013. © 2013 Wiley Periodicals, Inc. Using a myeloablative chemotherapy regimen, the authors have investigated the capacity of bone marrow derived cells to enter into the central nervous system. These cells migrated specifically to sites of injuries in models of stroke and Alzheimer's disease but did not repopulate the entire parenchyma.
Source: The Journal of Comparative Neurology - May 16, 2013 Category: Neurology Authors: Antoine Lampron, Pedro M. Pimentel‐Coelho, Serge Rivest Tags: Research Article Source Type: research