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Total 60 results found since Jan 2013.

Improve Your Memory A Whopping 27%
Traditional doctors think the best way to treat memory loss is with Big Pharma’s latest “breakthrough” drug. And when it’s proven not to work – not to mention dangerous – they simply pull another one out of their pocket… That’s why I’m so concerned about the media buzz surrounding Lecanemab, one of the latest FDA-approved Alzheimer’s drug. Because I want to be clear: It is NOT a wonder drug. Lecanemab is a pharmaceutical product that, in clinical trials, resulted in a slight decline in cases of early Alzheimer’s when compared to a placebo. But…it was also associated with a long list of extremel...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Source Type: news

Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study
Conclusions The prognosis of patients with acute ischemic stroke and active cancer varied considerably depending on stroke mechanism, distant metastasis, and coagulation abnormalities. The present study confirmed that coagulation abnormalities were crucial in determining the prognosis of such patients.PMID:37489755 | DOI:10.1161/JAHA.123.029618
Source: Atherosclerosis - July 25, 2023 Category: Cardiology Authors: Yasufumi Gon Manabu Sakaguchi Hiroshi Yamagami Soichiro Abe Hiroyuki Hashimoto Nobuyuki Ohara Daisuke Takahashi Yuko Abe Tsutomu Takahashi Takaya Kitano Shuhei Okazaki Kenichi Todo Tsutomu Sasaki Satoshi Hattori Hideki Mochizuki SCAN Study Investigators Source Type: research

Improved language function for post-stroke aphasia in the long term following repeated repetitive transcranial magnetic stimulation and intensive speech-language-hearing therapy: a case report
ConclusionsThe findings of the study indicate that the repeated use of repetitive transcranial magnetic stimulation and intensive speech-language-hearing therapy may be effective in improving and preserving language function and increasing cerebral blood flow for aphasia following stroke.
Source: Journal of Medical Case Reports - July 8, 2023 Category: General Medicine Source Type: research

Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men
Conclusions Among Japanese men, higher arterial stiffness was associated with lower Alzheimer disease signature volumes, whereas higher atherosclerotic burden was associated with brain vascular damage. Arterial stiffness and atherosclerotic burden may be independently associated with brain structural changes via different pathways.PMID:37232267 | DOI:10.1161/JAHA.122.028586
Source: Atherosclerosis - May 26, 2023 Category: Cardiology Authors: Nazar M Azahar Yuichiro Yano Aya Kadota Akihiko Shiino Ali H Syaifullah Naoko Miyagawa Keiko Kondo Mohammad Moniruzzaman Sayuki Torii Hiroyoshi Segawa Takashi Hisamatsu Akira Fujiyoshi Kazuhiko Nozaki Ikuo Tooyama Hirotsugu Ueshima Katsuyuki Miura SESSA R Source Type: research

Roche ’s BTK inhibitor fenebrutinib significantly reduced brain lesions in people with relapsing forms of multiple sclerosis
Fenebrutinib is an investigational, potent and highly selective oralBruton ’s tyrosine kinase (BTK) inhibitor, the only reversible BTK inhibitor currently in Phase III multiple sclerosis (MS) trialsPhase II study met its primary and secondary endpoints by reducing the total number of new gadolinium-enhancing T1 brain lesions and significantly reducing the total number of new or enlarging T2 brain lesions compared to placeboThe safety profile offenebrutinib was consistent with previous and ongoing clinical trials across more than 2,400 people to dateBasel, 17 May 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today p...
Source: Roche Media News - May 17, 2023 Category: Pharmaceuticals Source Type: news

Scientists tie third clinical trial death to experimental Alzheimer ’s drug
As enthusiasm mounts for a new experimental antibody that appears to slow cognitive decline in some Alzheimer’s patients, a third death linked to the drug during its clinical testing may amplify concerns about its safety. Science has obtained medical records showing a 79-year-old Florida woman participating in an ongoing trial of the antibody died in mid-September after experiencing extensive brain swelling and bleeding, as well as seizures. Multiple neuroscientists who reviewed the records at Science ’s request believe her death was likely caused by the antibody, lecanemab. “The brain swelling and t...
Source: ScienceNOW - December 21, 2022 Category: Science Source Type: news

As some hail new antibody treatment for Alzheimer ’s, safety and benefit questions persist
In a packed San Francisco conference room with a celebratory atmosphere, upbeat company representatives and scientists yesterday presented detailed clinical trial data on the first Alzheimer’s treatment shown to clearly, albeit modestly, slow the disease’s normal cognitive decline. The antibody therapy has buoyed a field marked by decades of failures. Now, it appears to be on the cusp of being greenlit by the U.S. Food and Drug Administration (FDA). Yet other researchers warn of potential risks, including brain swelling and brain hemorrhages that were linked to the recently disclosed deaths of two trial participants wh...
Source: Science of Aging Knowledge Environment - December 1, 2022 Category: Geriatrics Source Type: research

Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

Usefulness of maximum intensity projection images of non-enhanced CT for detection of hyperdense middle cerebral artery sign in acute thromboembolic ischemic stroke
ConclusionThe hyperdense MCA sign sensitivity on 5  mm MIP images was significantly higher than that on conventional 5 mm averaged CT images. This could be useful for the early initiation of proper therapy for patients with acute focal neurological deficits.
Source: Japanese Journal of Radiology - May 25, 2022 Category: Radiology Source Type: research

Systematic Screening for Atrial Fibrillation in Patients at Moderate-to-High Risk of Stroke 　- Potential to Increase the Atrial Fibrillation Detection Rate (SCAN-AF)
CONCLUSIONS: Sequential use of a BP monitor and handheld ECG for 4 weeks is a practical strategy for identifying undiagnosed AF in Japanese people at heightened risk of stroke.PMID:35125371 | DOI:10.1253/circj.CJ-21-0813
Source: Circulation Journal - February 7, 2022 Category: Cardiology Authors: Eiichi Watanabe Naohiko Takahashi Ronald Aronson Ako Ohsawa Yuriko Ishibashi Yuji Murakawa SCAN-AF Investigators Source Type: research

Correlation between fetal heart rate evolution patterns and magnetic resonance imaging findings in severe cerebral palsy: a longitudinal study
CONCLUSION: BGT-dominant brain damage accounted for 3/4 of the cases of CP in term or near-term infants, even in prenatal onset cases. Hypoxic-ischaemic insult has a major impact on CP development during the antenatal period.PMID:35007405 | DOI:10.1111/1471-0528.17089
Source: BJOG : An International Journal of Obstetrics and Gynaecology - January 10, 2022 Category: OBGYN Authors: Masahiro Nakao Yukiko Nanba Asumi Okumura Junichi Hasegawa Satoshi Toyokawa Kiyotake Ichizuka Naohiro Kanayama Shoji Satoh Nanako Tamiya Akihito Nakai Keiya Fujimori Tsugio Maeda Hideaki Suzuki Mitsutoshi Iwashita Akira Oka Tomoaki Ikeda Source Type: research