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Condition: Diabetes
Procedure: Coronary Artery Bypass Graft

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Total 437 results found since Jan 2013.

The FREEDOM trial: In appropriate patients with diabetes and multivessel coronary artery disease, CABG beats PCI
The Future Revascularization Evaluation in Patients With Diabetes Mellitus: Optimal Management of Multivessel Disease (FREEDOM) trial (N Engl J Med 2012; 367:2375–2384) was designed to resolve the long-standing debate over the optimal revascularization strategy in patients with diabetes mellitus and multivessel coronary artery disease. At a median follow-up of 3.8 years, the incidence of the primary outcome (a composite of death, myocardial infarction, and stroke) was significantly lower with bypass surgery than with percutaneous intervention.
Source: Cleveland Clinic Journal of Medicine - August 1, 2013 Category: Journals (General) Authors: AGGARWAL, B., GOEL, S. S., SABIK, J. F., SHISHEHBOR, M. H. Tags: Interpreting Key Trials Source Type: research

Electrocardiography series. Diabetes mellitus and heart disease.
Abstract Diabetes mellitus is responsible for diverse cardiovascular complications such as accelerated atherosclerosis, increased plaque burden and diffuse coronary lesions. It is also a major risk factor for myocardial infarction, stroke and peripheral vascular disease. Here, we present two cases. The first patient had subtle changes in the ECGs, with severe coronary artery disease requiring coronary artery bypass grafting, while the second had deep T wave inversion in the ECG and was found to have normal coronary arteries and nonischaemic cardiomyopathy. Although ECG failed to show the severity of the disease, i...
Source: Singapore Medical Journal - July 1, 2013 Category: Journals (General) Authors: Ambhore A, Teo SG, Poh KK Tags: Singapore Med J Source Type: research

Prognostic implications of DPP‐4 inhibitor vs. sulfonylurea use on top of metformin in a real world setting – results of the 1 year follow‐up of the prospective DiaRegis registry
ConclusionsThe present results confirm prior randomised controlled trial results in patients with type 2 diabetes from real world clinical practice demonstrating that DPP4‐I on top of prior metformin monotherapy result in similar HbA1c reductions within 12 months but a significant reduction in hypoglycaemia compared with sulfonylurea added to metformin. The reduction in vascular events observed has to be verified in larger cohorts.
Source: International Journal of Clinical Practice - August 28, 2013 Category: Internal Medicine Authors: A. K. Gitt, P. Bramlage, C. Binz, M. Krekler, E. Deeg, D. Tschöpe Tags: Original Paper Source Type: research

New heart op could save 'thousands of lives'
Conclusion This was a well-designed study which showed that over the course of two years, the risk of another non-fatal or fatal heart attack is reduced in heart attack patients who have preventive stents inserted in narrowed arteries at the same time as a procedure to insert stents into the blocked coronary artery that caused their heart attack. However, an important point to note is that the study results do not apply to all patients who have had a heart attack. The study only looked at the group of patients who had a specific type of heart attack – a STEMI – and needed an emergency stent placement operation. ...
Source: NHS News Feed - September 3, 2013 Category: Consumer Health News Tags: Heart/lungs Genetics/stem cells Source Type: news

The Morbidity and Mortality Outcomes of Indigenous Australian Peoples after Isolated Coronary Artery Bypass Graft Surgery: The Influence of Geographic Remoteness
Conclusion: Indigenous Australian peoples were at greater risk for prolonged ventilation and combined morbidity outcome, and experienced poorer survival in the longer term. Higher mortality risk among Indigenous Australians was evident even after controlling for remoteness and accessibility to services.
Source: Heart, Lung and Circulation - April 1, 2013 Category: Cardiology Authors: Anil Prabhu, Phillip J. Tully, Jayme S. Bennetts, Sigrid C. Tuble, Robert A. Baker Tags: Original Articles Source Type: research

Health related quality of life in coronary patients and its association with their cardiovascular risk profile: Results from the EUROASPIRE III survey
Conclusion: Overall, a large heterogeneity was observed in HRQoL values between countries and patient groups. There seems to be a significant association between quality of life and patient characteristics with lifestyle risk factors as important determinants of HRQoL.
Source: International Journal of Cardiology - December 3, 2012 Category: Cardiology Authors: Delphine De Smedt, Els Clays, Lieven Annemans, Frank Doyle, Kornelia Kotseva, Andrzej Pająk, Christof Prugger, Catriona Jennings, David Wood, Dirk De Bacquer Tags: Original Articles Source Type: research

Five-year outcomes of surgical or percutaneous myocardial revascularization in diabetic patients
Abstract: Background: The study compares five-year clinical outcomes of CABG vs PCI in a real world population of diabetic patients with multivessel coronary disease since it is not clear whether to prefer surgical or percutaneous revascularization.Methods: Between July 2002 and December 2008, 2885 multivessel coronary diabetic patients underwent revascularization (1466 CABG and 1419 PCI) at hospitals in Emilia-Romagna Region, Italy and were followed for 1827±617days by record linkage of two clinical registries with the regional administrative database of hospital admissions and the mortality registry. Five-year incidence...
Source: International Journal of Cardiology - November 19, 2012 Category: Cardiology Authors: Giovanni Andrea Contini, Francesco Nicolini, Daniela Fortuna, Davide Pacini, Davide Gabbieri, Luigi Vignali, Marco Valgimigli, Antonio Manari, Claudio Zussa, Paolo Guastaroba, Rossana De Palma, Roberto Grilli, Tiziano Gherli Tags: Original Articles Source Type: research

Contemporary Analysis of Incidence and Outcomes of Stent Thrombosis Presenting as ST Elevation Myocardial Infarction in a Primary Percutaneous Coronary Intervention Cohort
There are limited data about the effectiveness of primary percutaneous coronary intervention (PPCI) for stent thrombosis treatment. We aimed to evaluate the prevalence and outcomes of PPCI in patients with ST elevation acute myocardial infarction (STEMI) due to stent thrombosis, and comparing the outcomes with patients treated for de novo coronary thrombosis. This was an observational cohort study of 2,935 patients who underwent PPCI from 2003 to 2011 with follow-up for a median of 3.0 years (interquartile range 1.2 to 4.6). The primary end point was the first major adverse cardiac event (MACE) defined as death, nonfatal ...
Source: The American Journal of Cardiology - September 9, 2013 Category: Cardiology Authors: Daniel A. Jones, Sean Gallagher, Krishnaraj S. Rathod, Mohammed Akhtar, Charles J. Knight, Martin T. Rothman, Akhil Kapur, Anthony Mathur, Ajay K. Jain, Adam D. Timmis, Elliot J. Smith, Andrew Wragg Tags: Coronary Artery Disease Source Type: research

Silent Coronary Artery Disease in Japanese Patients Undergoing Carotid Artery Stenting
Conclusions: Perioperative CAD screening revealed that silent CAD was frequently diagnosed in Japanese patients scheduled for CAS, particularly in those with DM and/or bilateral carotid stenosis.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2013 Category: Neurology Authors: Yukiko Enomoto, Shinichi Yoshimura, Kiyofumi Yamada, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi, Toru Iwama Tags: Original Articles Source Type: research

New Insights Into Surgery Versus Stents For Diabetics With Multivessel Disease
Last year the large NHLBI FREEDOM trial demonstrated that bypass surgery was superior to PCI when treating diabetic patients who have multivessel coronary disease. CABG resulted in significant reductions in death and MI, but this was offset slightly by a higher rate of stroke in the CABG group. Now a new report from FREEDOM published in JAMA suggests that the reduction in important clinical endpoints may not translate into large differences in health status and quality of life.
Source: Forbes.com Healthcare News - October 17, 2013 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

Increased Glycemic Variability in Patients with Elevated Preoperative HbA1C Predicts Adverse Outcomes Following Coronary Artery Bypass Grafting Surgery.
CONCLUSIONS: Postoperative glycemic variability is associated with MAEs after cardiac surgery. Glycemic variability is only measured when the patient leaves the intensive care unit, and there is no opportunity to intervene earlier. Preoperative HbA1C identifies risk for postoperative glycemic variability and may provide a more rational guide for targeting measures to reduce variability. PMID: 24445629 [PubMed - in process]
Source: Anesthesia and Analgesia - January 24, 2014 Category: Anesthesiology Authors: Subramaniam B, Lerner A, Novack V, Khabbaz K, Paryente-Wiesmann M, Hess P, Talmor D Tags: Anesth Analg Source Type: research

Comparing coronary artery bypass grafting with drug-eluting stenting in patients with diabetes mellitus and multivessel coronary artery disease: a meta-analysis
CONCLUSIONS Percutaneous coronary intervention with DES in patients with diabetes and multivessel CAD is safe, but has a high risk of long-term repeat revascularization. CABG should remain the standard procedure for diabetic patients with multivessel CAD.
Source: Interactive CardioVascular and Thoracic Surgery - February 15, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Li, X., Kong, M., Jiang, D., Dong, A. Tags: Adult Cardiac Source Type: research

Optimal Conduit for Diabetic Patients: Propensity Analysis of Radial and Right Internal Thoracic Arteries.
CONCLUSIONS: In diabetic patients undergoing multivessel revascularization with either RA or RITA grafts to the circumflex coronary, long-term survival is similar. However, RA patients experienced significantly fewer respiratory or sternal wound adverse events. The RA is the preferred conduit to extend to more diabetic patients the recognized survival benefit of a multiple arterial graft strategy. PMID: 24878172 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 28, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Hoffman DM, Dimitrova KR, Lucido DJ, Dincheva GR, Geller CM, Balaram SK, Ko W, Swistel DG, Tranbaugh RF Tags: Ann Thorac Surg Source Type: research

Abstract 110: Long-Term Health Status Outcomes in Young Women with Acute Myocardial Infarction: Results from the VIRGO Study Session Title: Poster Session I
Conclusion: Compared with men, young women are more likely to have "poor" health status outcomes after AMI. This information is critically important in developing targets for gender-specific interventions to improve young women’s recovery post AMI.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Dreyer, R. P., Strait, K. M., Lichtman, J. H., Lorenze, N., D'Onofrio, G., Bueno, H., Spertus, J. A., Krumholz, H. M. Tags: Session Title: Poster Session I Source Type: research

Abstract 201: Gemfibrozil In Combination With Statin Is Associated With Reduction In All Cause Mortality: A Retrospective Cohort Study Session Title: Poster Session II
Conclusion: Combination of gemfibrozil with statin is associated with greater reduction in all cause mortality compared to statins alone.Keywords: gemfibrozil, mortality
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Aryal, S. R., Newman, W. Tags: Session Title: Poster Session II Source Type: research