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What is the diameter of a fibrin fiber?
CONCLUSION: We performed a systematic, multitechnique survey assessing fibrin fiber diameters under a range of biochemical conditions. The similarity in the diameter values obtained using SEM and superresolution imaging suggests that drying and fixation during SEM sample preparation do not dramatically alter fiber cross-sections. Congruence, under certain conditions, between diameter values obtained using SEM, superresolution fluorescence imaging, and turbidimetry demonstrates the feasibility of a fibrin diameter standardization project.PMID:37601015 | PMC:PMC10439396 | DOI:10.1016/j.rpth.2023.100285
Source: Thrombosis and Haemostasis - August 21, 2023 Category: Hematology Authors: Heather A Belcher Martin Guthold Nathan E Hudson Source Type: research

Consensus statement for the management of incidentally found brain white matter hyperintensities in general medical practice
Med J Aust. 2023 Aug 21. doi: 10.5694/mja2.52079. Online ahead of print.ABSTRACTINTRODUCTION: There is a paradigm shift in our understanding of white matter hyperintensities (WMH) found on brain imaging. They were once thought to be a normal phenomenon of ageing and, therefore, warranted no further investigation. However, evidence now suggests these lesions are markers of poor brain and cardiovascular health, portending an increased risk of stroke, cognitive decline, depression and death. Nevertheless, no specific guidelines exist for the management of incidentally found WMH for general medical practitioners and other clin...
Source: Med J Aust - August 21, 2023 Category: General Medicine Authors: Thomas P Ottavi Elizabeth Pepper Grant Bateman Mark Fiorentino Amy Brodtmann Source Type: research

What is the diameter of a fibrin fiber?
CONCLUSION: We performed a systematic, multitechnique survey assessing fibrin fiber diameters under a range of biochemical conditions. The similarity in the diameter values obtained using SEM and superresolution imaging suggests that drying and fixation during SEM sample preparation do not dramatically alter fiber cross-sections. Congruence, under certain conditions, between diameter values obtained using SEM, superresolution fluorescence imaging, and turbidimetry demonstrates the feasibility of a fibrin diameter standardization project.PMID:37601015 | PMC:PMC10439396 | DOI:10.1016/j.rpth.2023.100285
Source: Thrombosis and Haemostasis - August 21, 2023 Category: Hematology Authors: Heather A Belcher Martin Guthold Nathan E Hudson Source Type: research

Consensus statement for the management of incidentally found brain white matter hyperintensities in general medical practice
Med J Aust. 2023 Aug 21. doi: 10.5694/mja2.52079. Online ahead of print.ABSTRACTINTRODUCTION: There is a paradigm shift in our understanding of white matter hyperintensities (WMH) found on brain imaging. They were once thought to be a normal phenomenon of ageing and, therefore, warranted no further investigation. However, evidence now suggests these lesions are markers of poor brain and cardiovascular health, portending an increased risk of stroke, cognitive decline, depression and death. Nevertheless, no specific guidelines exist for the management of incidentally found WMH for general medical practitioners and other clin...
Source: Medical Journal of Australia - August 21, 2023 Category: General Medicine Authors: Thomas P Ottavi Elizabeth Pepper Grant Bateman Mark Fiorentino Amy Brodtmann Source Type: research

What is the diameter of a fibrin fiber?
CONCLUSION: We performed a systematic, multitechnique survey assessing fibrin fiber diameters under a range of biochemical conditions. The similarity in the diameter values obtained using SEM and superresolution imaging suggests that drying and fixation during SEM sample preparation do not dramatically alter fiber cross-sections. Congruence, under certain conditions, between diameter values obtained using SEM, superresolution fluorescence imaging, and turbidimetry demonstrates the feasibility of a fibrin diameter standardization project.PMID:37601015 | PMC:PMC10439396 | DOI:10.1016/j.rpth.2023.100285
Source: Thrombosis and Haemostasis - August 21, 2023 Category: Hematology Authors: Heather A Belcher Martin Guthold Nathan E Hudson Source Type: research

P124/272 Initial encounter with a cutting-edge mobile head CT scanner (Somatom On.site) in a neuro-intensive care unit
ConclusionThe study demonstrates the clinical effectiveness of modern mobile CT scanners in neurointensive care units. The Somatom On.site provides sufficient image quality, saves time and supports timely decision making. The integration of mobile CT scanners in NICUs improves patient care and workflow. Prospective studies are needed to validate these findings and assess the long-term impact in NICUs and other units, such as stroke units.Disclosure of InterestCK serves as consultants for Acandis GmbH (Pforzheim, Germany) and proctor for MicroVention Inc./Sequent Medical (Aliso Viejo, CA, USA).
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Goertz, L., Al-Sewaidi, Y., Habib, M., Ranft, A., Kabbasch, C. Tags: 3.1 OTHER - Innovation Source Type: research

P131/196 Comparison of accuracy of CT perfusion software packages in patients with acute ischemic stroke. Can we get closer to the core?
ConclusionCore volume estimations and accuracy vary significantly between CTP software packages and should be acknowledged. Best agreement with segmented infarct volumes was provided by CP. SV method B with smoothing showed the best results for syngo.via.Disclosure of Interestnothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Thormann, M., Faltass, M., Schwab, R., Stefan, K., Behme, D. Tags: 2.2 ISCHEMIC - Imaging Source Type: research

P163/235 Thrombolysis and collateral flow in interhospital transfer for thrombectomy: implications for recanalization and infarct growth
ConclusionCollateral flow and thrombolysis may have a positive interaction in macrovascular recanalization. However, thrombolysis does not appear to interfere with collateral-mediated infarct growthDisclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Sousa, J., Bernardo-Castro, S., Machado, R. B., Maia, C., Cruz, L., Simoes, J., Martins, A. I., Bras, A., Almendra, L., Nunes, C., Machado, C., Rodrigues, B., Veiga, R., Nunes, C., Silva, F., Pereira R Cordeiro Santo, G. A., Machado, E., Freitas, J. S. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

O05/57 Validation of a novel multiphase CTA perfusion tool compared to CTP in patients with suspected acute ischemic stroke
Conclusion mCTAp shows similar performance compared to CTP in assisting readers to detect ischemia and its side/location, requiring less radiation exposure, acquisition time and contrast-dose compared to additional-CTP, but mainly as it relates to proximal vessel occlusions.Disclosure of InterestDr. Menon holds patents on systems of triage in acute stroke, for LVO detection and for mCTAp, and stock ownership in Circle Cardiovascular Inc. Dr. Bala has nothing to declare. Dr. Duszynski is an employee of, and holds stock options for Circle Cardiovascular Imaging Inc. Dr. Nayem Pinky, Dr. Golan and Luis A Souto Maior Neto are ...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Benali, F., Zhang, J., Pinky, N., Bala, F., Alhabli, I., Golan, R., Neto, S., Elebute, I., Duszynski, C., Qiu, W., Menon, B. Tags: 2.2 ISCHEMIC - Imaging Source Type: research

O16/158 Artificial Intelligence based nationwide centralised decision supporting system for improving stroke case efficiency in Hungary
ConclusionUsing AI based centralized stroke imaging network fast and reliable decision support can be provided to a large nationwide stroke care system. The system was installed with the support of an EU grant EFOP 5.2.6.Disclosure of InterestIstvan Szikora has a consulting agreement with Brainomix Ltd.Zoltan Chadaide is a former employee of Brainomix Ltd.Edvard Benes is owner and CEO of eRAD-BBThe system was built by the support of an EU grant EFOP 5.2.6.The other authors have no relevant conflict of interest.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Szikora, I., Magyar, B., Papai, G., Szudi, G., Kondor, M., Czencz, M., Nardai, S., Chadaide, Z., Benes, E., Ovary, C., Eross, L. Tags: 2.2 ISCHEMIC - Imaging Source Type: research

P023/222 Traveler, there is no path. The path is made by walking
ConclusionCT angiography showed an apparent lack of access to reach the basilar artery. Nevertheless, the active search for unconventional roads led us to take advantage of an, a priori, non-navigable vessel, with successful recanalization. This underlines that patients should not be refused endovascular treatment based on the apparent lack of access to the cerebral circulation.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Rodriguez-Ares, T., Baptista, M., Fragata, I., Reis, J. Tags: 4.4 CASE PROPOSAL - Complications Source Type: research

Alberta Stroke Program Early CT Score and collateral status predict target mismatch in large vessel occlusion with delayed time windows
Conclusions NCCT ASPECTS had a strong correlation with CTP core volumes in patients with LVO-AIS in delayed time windows. Combining NCCT ASPECTS with sCTA-CS resulted in a more accurate prediction of target mismatch. If a CTP scan is not available, NCCT ASPECTS combined with sCTA-CS may guide clinicians in making treatment decisions.
Source: Journal of NeuroInterventional Surgery - August 17, 2023 Category: Neurosurgery Authors: Hang, Y., Wang, C. d., Ni, H., Cao, Y., Zhao, L. B., Liu, S., Shi, H.-B., Jia, Z. Tags: Ischemic stroke Source Type: research

Rural-urban and geographical differences in prognosis of atrial fibrillation in Finland: a nationwide cohort study
CONCLUSIONS: Rural-urban differences in prognosis of AF in Finland appear minimal, whereas considerable disparities exist between HDs.PMID:37571929 | DOI:10.1177/14034948231189918
Source: Scandinavian Journal of Public Health - August 12, 2023 Category: International Medicine & Public Health Authors: Konsta Teppo K E Juhani Airaksinen Olli Halminen Jussi Jaakkola Miika Linna Jari Haukka Jukka Putaala Pirjo Mustonen Janne Kinnunen Juha Hartikainen Mika Lehto Source Type: research