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Condition: Heart Attack

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Total 38 results found since Jan 2013.

New ultrasound device may add in detecting risk for heart attack, stroke
(North Carolina State University) Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a new ultrasound device that could help identify arterial plaque that is at high risk of breaking off and causing heart attack or stroke.
Source: EurekAlert! - Biology - April 24, 2014 Category: Biology Source Type: news

Molecular therapy set to protect at-risk patients against heart attack and stroke
(Charit é - Universit ä tsmedizin Berlin) Even a single dose of a specific ribonucleic acid molecule, known as a small interfering RNA (siRNA), offers patients at high risk of cardiovascular disease long-lasting protection against high LDL cholesterol -- one of the main risk factors for heart attack and stroke. This is the result of a clinical study that researchers from Charit é and Imperial College London have published as leading authors in the current edition of New England Journal of Medicine.
Source: EurekAlert! - Biology - March 30, 2017 Category: Biology Source Type: news

Ban on trans fats in diet may reduce heart attacks and stroke
(Yale University) People living in areas that restrict trans fats in foods had fewer hospitalizations for heart attack and stroke compared to residents in areas without restrictions, according to a study led by a Yale researcher. This finding suggests the benefit of limiting trans fats could have widespread impact as trans fat restrictions are set to expand nationwide.
Source: EurekAlert! - Biology - April 12, 2017 Category: Biology Source Type: news

NYU Dentistry awarded $1.9M NIH grant to study mitochondrial changes behind stroke, heart attack
(New York University) The National Institute of General Medical Sciences, part of the National Institutes of Health (NIH), has awarded NYU College of Dentistry's Evgeny Pavlov a grant to study a phenomenon called mitochondrial permeability transition, one of the central causes of tissue damage during stroke and heart attack.
Source: EurekAlert! - Biology - February 1, 2021 Category: Biology Source Type: news

Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: Rationale and design of the Hygia Project.
This article describes the rationale, objectives, design and conduct of the ambulatory blood pressure monitoring (ABPM)-based Hygia Project. Given the substantial evidence of the significantly better prognostic value of ABPM compared to clinic BP measurements, several international guidelines now propose ABPM as a requirement to confirm the office diagnosis of hypertension. Nonetheless, all previous ABPM outcome investigations, except the Monitorización Ambulatoria para Predicción de Eventos Cardiovasculares study (MAPEC) study, relied upon only a single, low-reproducible 24 h ABPM assessment per participant done at stud...
Source: Chronobiology International - May 23, 2016 Category: Biology Authors: Hermida RC Tags: Chronobiol Int Source Type: research

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning
Publication date: 2014 Source:Redox Biology, Volume 2 Author(s): Theodore Kalogeris , Yimin Bao , Ronald J. Korthuis Reductions in the blood supply produce considerable injury if the duration of ischemia is prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue damage and extend the size of an evolving infarct. Being highly metabolic organs, the heart and brain are particularly vulnerable to the deleterious effects of ischemia/reperfusion (I/R). While the pathogenetic mechanisms contributing to I/R-induced tissue injury and infarction are multifactorial, the relative importance of eac...
Source: Redox Biology - October 12, 2014 Category: Biology Source Type: research

Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations
(University of California - Los Angeles) A UCLA scientist and other researchers who have just sequenced the first turtle genome uncovered clues about how people can benefit from the shelled creatures' remarkable longevity and ability to survive long stretches without oxygen. Understanding the natural mechanisms turtles use to protect the heart and brain from oxygen deprivation may one day improve treatments for heart attack or stroke. Lead author UCLA Professor Brad Shaffer collaborated with Washington University's Genome Institute and 58 co-authors.
Source: EurekAlert! - Biology - April 10, 2013 Category: Biology Source Type: news

Wayne State discovers potential treatment for better heart health in hemodialysis patients
(Wayne State University - Office of the Vice President for Research) Researchers at Wayne State University have discovered a potential way to improve the lipid profiles in patients undergoing hemodialysis that may prevent cardiovascular disease common in these patients. Patients undergoing hemodialysis for kidney failure are at a greater risk for atherosclerosis, a common disease in which plaque builds up inside the arteries. Atherosclerosis can lead to serious problems including heart attack, stroke or even death.
Source: EurekAlert! - Biology - January 15, 2014 Category: Biology Source Type: news

Aging and regeneration in vertebrates.
Abstract Aging is marked by changes that affect organs and resident stem cell function. Shorting of telomeres, DNA damage, oxidative stress, deregulation of genes and proteins, impaired cell-cell communication, and an altered systemic environment cause the eventual demise of cells. At the same time, reparative activities also decline. It is intriguing to correlate aging with the decline of regenerative abilities. Animal models with strong regenerative capabilities imply that aging processes might not be affecting regeneration. In this review, we selectively present age-dependent changes in stem/progenitor cells th...
Source: Current Topics in Developmental Biology - February 15, 2014 Category: Biology Authors: Sousounis K, Baddour JA, Tsonis PA Tags: Curr Top Dev Biol Source Type: research

Effects of vitamin E on peroxisome proliferator-activated receptor γ and nuclear factor-erythroid 2-related factor 2 in hypercholesterolemia induced atherosclerosis.
Abstract Atherosclerosis and associated cardiovascular complications such as stroke and myocardial infarction are major causes of morbidity and mortality. We have previously reported a significant increase in mRNA levels of the scavenger receptor CD36 in aortae of cholesterol fed rabbits and shown that vitamin E treatment attenuated increased CD36 mRNA expression. In the present study, we further investigated the redox signaling pathways associated with protection against atherogenesis induced by high dietary cholesterol and correlated these with CD36 expression and the effects of vitamin E supplementation in a ra...
Source: Free Radical Biology and Medicine - February 26, 2014 Category: Biology Authors: Bozaykut P, Karademir B, Yazgan B, Sozen E, Siow RC, Mann GE, Ozer NK Tags: Free Radic Biol Med Source Type: research

Research findings link post-heart attack biological events that provide cardioprotection
(UT Southwestern Medical Center) Heart attack and stroke are among the most serious threats to health. But novel research at UT Southwestern Medical Center has linked two major biological processes that occur at the onset of these traumatic events and, ultimately, can lead to protection for the heart.
Source: EurekAlert! - Biology - March 13, 2014 Category: Biology Source Type: news

Researchers identify new protein markers that may improve understanding of heart disease
(Intermountain Medical Center) Researchers at the Intermountain Medical Center Heart Institute in Murray, Utah, have discovered that elevated levels of two recently identified proteins in the body are inflammatory markers and indicators of the presence of cardiovascular disease. These newly identified markers of inflammation, GlycA and GlycB, have the potential to contribute to better understanding of the inflammatory origins of heart disease and may be used in the future to identify a heart patient's future risk of suffering a heart attack, stroke, or even death.
Source: EurekAlert! - Biology - March 30, 2014 Category: Biology Source Type: news

Researchers reveal a new pathway through the sodium pump
(Rockefeller University Press) The ubiquitous sodium pump appears to be more versatile than we thought. In addition to its role as a sodium and potassium ion transporter, researchers now show that the pump can simultaneously import protons into the cell. The study not only provides evidence of 'hybrid' function by the pump, it also raises important questions about whether the inflow of protons through sodium pumps might play a role in certain pathologies, including heart attack and stroke.
Source: EurekAlert! - Biology - March 31, 2014 Category: Biology Source Type: news

Scientists target receptor to treat diabetic retinopathy
(Medical College of Georgia at Georgia Regents University) Like a daily pill to lower cholesterol can reduce heart attack and stroke risk, an easy-to-use agent that reduces eye inflammation could help save the vision of diabetics, scientists say.
Source: EurekAlert! - Biology - April 21, 2014 Category: Biology Source Type: news

Postconditioning with a CpG containing Oligodeoxynucleotide ameliorates myocardial infarction in a murine closed-chest model
Publication date: Available online 29 October 2014 Source:Life Sciences Author(s): Se-Chan Kim , Shuijing Wu , Xiangming Fang , Jens Neumann , Lars Eichhorn , Grigorij Schleifer , Olaf Boehm , Rainer Meyer , Stilla Frede , Andreas Hoeft , Georg Baumgarten , Pascal Knuefermann Aims Toll-like receptor (TLR)9 ligand CpG-oligodeoxynucleotide (CpG-ODN) exerts preconditioning in myocardial ischemia/reperfusion. We hypothesized a postconditioning effect of CpG-ODN in a murine closed-chest model of myocardial infarction. Materials and Methods C57BL/6 (12weeks, male, WT) mice were instrumented at the left anterior descending art...
Source: Life Sciences - November 4, 2014 Category: Biology Source Type: research