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Total 137 results found since Jan 2013.

Does exposure to marijuana cause myocardial infarction?
2 out of 5 stars Prolonged cardiac arrest complicating a massive ST-segment elevation myocardial infarction associated with marijuana consumption. Orsini J et al. J Community Hosp Intern Med Perspect 2016 Sept 7;6(4):31695 Full Text The medical literature contains scattered, rare case reports and series describing myocardial infarction, acute coronary syndrome, and cardiac arrest associated with exposure to cannabis. (Extreme emphasis on the word “associated.”) This literature is limited by a number of crippling problems, including failure to screen completely for presence of other drugs, failure to collect com...
Source: The Poison Review - November 12, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cannabis cardiotoxicity heart attack cardiac arrest marijuana myocardial infarction Source Type: news

High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation.
Abstract Neuroinflammation is a pathophysiological process present in a number of neurodegenerative disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, traumatic brain injury including chronic traumatic encephalopathy and other age-related CNS disorders. Although there is still much debate about the initial trigger for some of these neurodegenerative disorders, during the progression of disease, broad range anti-inflammatory drugs including cytokine suppressive anti-inflammatory drugs (CSAIDs) might be promising therapeutic options to limit neuroinflammation and improve the c...
Source: Archives of Toxicology - February 14, 2017 Category: Toxicology Authors: Ullah F, Liang A, Rangel A, Gyengesi E, Niedermayer G, Münch G Tags: Arch Toxicol Source Type: research

Incidence of fatal snake bite in Australia: A coronial based retrospective study (2000-2016).
CONCLUSIONS: Death from snake bite remains rare in Australia, and has maintained a steady rate for over 20 years. Usually considered a 'rural issue', and with varying recorded causes of death, a nationally co-ordinated effort to further review the national picture of envenoming in Australia can inform education and resource needs within state and local contexts. PMID: 28288937 [PubMed - as supplied by publisher]
Source: Toxicon - March 9, 2017 Category: Toxicology Authors: Welton R, Liew D, Braitberg G Tags: Toxicon Source Type: research

Ischemic stroke due to wasp sting: a case report
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Source: Clinical Toxicology - April 3, 2017 Category: Toxicology Authors: Xi Tao Liang Huang Cuini Fang Chujuan Liu Liang Qing Huaan Cai Source Type: research

DIESEL EXHAUST PARTICLES (DEP) PRE-EXPOSURE CONTRIBUTES TO THE ANTI-OXIDANT RESPONSE IMPAIRMENT IN hCMEC/D3 DURING POST-OXYGEN AND GLUCOSE DEPRIVATION DAMAGE.
Abstract Recently, air pollution has been identified as a significant modifiable risk factor to the increasing stroke burden. Diesel exhaust particles, characterized by high polycyclic aromatic hydrocarbons content, constitute an important component of outdoor air pollution and is known to cause oxidative stress, and could therefore contribute to and exacerbate the effects of ROS in post-ischemic injury. hCMEC/D3 cells have been submitted to 48h treatment with diesel exhaust particles (25μg/ml and 50μg/ml, DEP50) or alternatively to 3h of oxygen and glucose deprivation, followed by 1h of oxygen and glucose resto...
Source: Toxicology Letters - April 8, 2017 Category: Toxicology Authors: Farina F, Lonati E, Brambilla A, Magro RD, Milani C, Botto L, Sancini G, Palestini P, Bulbarelli A Tags: Toxicol Lett Source Type: research

The role of platelets in hemostasis and the effects of snake venom toxins on platelet function.
Abstract The human body has a set of physiological processes, known as hemostasis, which keeps the blood fluid and free of clots in normal vessels; in the case of vascular injury, this process induces the local formation of a hemostatic plug, preventing hemorrhage. The hemostatic system in humans presents complex physiological interactions that involve platelets, plasma proteins, endothelial and subendothelial structures. Disequilibrium in the regulatory mechanisms that control the growth and the size of the thrombus is one of the factors that favors the development of diseases related to vascular disorders such a...
Source: Toxicon - April 20, 2017 Category: Toxicology Authors: de Queiroz MR, de Sousa BB, da Cunha Pereira DF, Mamede CCN, Matias MS, de Morais NCG, de Oliveira Costa J, de Oliveira F Tags: Toxicon Source Type: research

Estimating the effect of differing assumptions on the population health impact of introducing a Reduced Risk Tobacco Product in the USA
Publication date: Available online 24 June 2017 Source:Regulatory Toxicology and Pharmacology Author(s): Peter N. Lee, John S. Fry, John F. Hamling, Zheng Sponsiello-Wang, Gizelle Baker, Rolf Weitkunat We use Population Health Impact Modelling to assess effects on tobacco prevalence and mortality of introducing a Reduced Risk Tobacco Product (RRP). Simulated samples start in 1990 with a US-representative smoking prevalence. Individual tobacco histories are updated annually until 2010 using estimated probabilities of switching between never/current/former smoking where the RRP is not introduced, with current users subdivid...
Source: Regulatory Toxicology and Pharmacology - June 24, 2017 Category: Toxicology Source Type: research

Estimating the effect of differing assumptions on the population health impact of introducing a Reduced Risk Tobacco Product in the USA.
Abstract We use Population Health Impact Modelling to assess effects on tobacco prevalence and mortality of introducing a Reduced Risk Tobacco Product (RRP). Simulated samples start in 1990 with a US-representative smoking prevalence. Individual tobacco histories are updated annually until 2010 using estimated probabilities of switching between never/current/former smoking where the RRP is not introduced, with current users subdivided into cigarette/RRP/dual users where it is. RRP-related mortality reductions from lung cancer, IHD, stroke and COPD are derived from the histories and the assumed relative risks of th...
Source: Regulatory Toxicology and Pharmacology : RTP - June 23, 2017 Category: Toxicology Authors: Lee PN, Fry JS, Hamling JF, Sponsiello-Wang Z, Baker G, Weitkunat R Tags: Regul Toxicol Pharmacol Source Type: research

Caffeine and cardiovascular health
This report evaluates the scientific literature on caffeine with respect to potential cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD), coronary heart disease (CHD) and acute myocardial infarction (AMI), effects on arrhythmia, heart failure, sudden cardiac arrest, stroke, blood pressure, hypertension, and other biomarkers of effect, including heart rate, cerebral blood flow, cardiac output, plasma homocysteine levels, serum cholesterol levels, electrocardiogram (EKG) parameters, heart rate variability, endothelial/platelet function and plasma/urine catecholamine levels. Caffeine in...
Source: Regulatory Toxicology and Pharmacology - July 27, 2017 Category: Toxicology Source Type: research

Caffeine and cardiovascular health.
This report evaluates the scientific literature on caffeine with respect to potential cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD), coronary heart disease (CHD) and acute myocardial infarction (AMI), effects on arrhythmia, heart failure, sudden cardiac arrest, stroke, blood pressure, hypertension, and other biomarkers of effect, including heart rate, cerebral blood flow, cardiac output, plasma homocysteine levels, serum cholesterol levels, electrocardiogram (EKG) parameters, heart rate variability, endothelial/platelet function and plasma/urine catecholamine levels. Caffeine in...
Source: Regulatory Toxicology and Pharmacology : RTP - July 26, 2017 Category: Toxicology Authors: Turnbull D, Rodricks JV, Mariano GF, Chowdhury F Tags: Regul Toxicol Pharmacol Source Type: research

Patterns of botulinum toxin treatment for spasticity and bleeding complications in patients with thrombotic risk.
Abstract The purpose of this study was to assess the prevalence of compartment syndrome or major bleeding episodes and compare compartment syndrome, patient and intervention characteristics in 110 patients with stroke (treated with Warfarin, new oral anticoagulants, antiplatelet, or no anticoagulants) treated for spasticity in deep leg compartment muscles with botulinum toxin injections [onabotulinumtoxinA (n = 77); incobotulinumtoxinA (n = 33)]. We reviewed 674 injection cycles (range 1-25 cycles per patient) and found no cases of compartment syndrome in any patient groups. PMID: 28919457 [PubMed - as supplied by publisher]
Source: Toxicon - September 15, 2017 Category: Toxicology Authors: Phadke CP, Thanikachalam V, Ismail F, Boulias C Tags: Toxicon Source Type: research

Cardio-Respiratory function during exercise in the cobia, Rachycentron canadum: The impact of crude oil exposure
In this study, we test this hypothesis by simultaneously measuring cardiovascular performance, oxygen consumption, and swim performance in a pelagic teleost, the cobia (Rachycentron canadum). Metabolic rate increased over 300% in both groups during the swim trial but as the fish approached the critical swim speed (U crit) MO2 was 12% lower in the oil exposed fish. Further stroke volume was initially 35% lower while heart rate was 15% higher in the oil exposed compared to control fish. Our findings suggested while aspects of cardiovascular and metabolic function are altered by oil exposure, additional studies are needed to ...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - September 20, 2017 Category: Toxicology Source Type: research

Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice.
Abstract Endothelial cells of cerebral microvessels are one of the components of blood-brain-barrier (BBB), which are connected by tight junctions (TJs). BBB disruption in cerebral diseases such as ischemic stroke, Alzhemer's disease, multiple sclerosis and traumatic brain injury is implicated to exacerbate the disease progression. Astragaloside IV (ASIV) isolated from Astragalus membranaceus prevents BBB breakdown in rodents induced with cerebral edema and experimental autoimmune encephalomyelitis. However, its underlying molecular mechanism has not been elucidated yet. In present study, ASIV was found to prevent...
Source: Toxicology and Applied Pharmacology - December 30, 2017 Category: Toxicology Authors: Li H, Wang P, Huang F, Jin J, Wu H, Zhang B, Wang Z, Shi H, Wu X Tags: Toxicol Appl Pharmacol Source Type: research

Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine
Publication date: Available online 8 March 2018 Source:Aquatic Toxicology Author(s): Connor M. Pettem, Jennifer M. Briens, David M. Janz, Lynn P. Weber Selenium (Se) is considered as an essential trace element, involved in important physiological and metabolic functions for all vertebrate species. Fish require dietary concentrations of 0.1 to 0.5 μg Se/g dry mass (d.m.) to maintain normal physiological and selenoprotein function, however concentrations exceeding 3 μg/g d.m. have been shown to cause toxicity. As Se is reported to have a narrow margin between essentiality and toxicity, there is growing concern surroun...
Source: Aquatic Toxicology - March 9, 2018 Category: Toxicology Source Type: research

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